Antilipase and antioxidant activity of Phyllanthus niruri ethanolic extract

The aim of this study is to determine the antilipase and antioxidant activity of Phyllanthus niruri methanolic extract. The inhibitory activity against porcine pancreatic lipase (PPL) was determined by measuring the hydrolysis of p-nitrophenyl butyrate to p-nitrophenol at 405 nm. The crude extract e...

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Main Authors:	Raja Abd. Rahman, Raja Noor Zaliha, Alias, Norsyuhada, Thean, Chor Leow, Mohamad Ali, Mohd. Shukuri, Ahmad Tajudin, Asilah, Salleh, Abu Bakar
Format:	Article
Language:	English
Published:	American-Eurasian Network for Scientific Information ( AENSI) 2015
Subjects:	RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/53232/ http://irep.iium.edu.my/53232/ http://irep.iium.edu.my/53232/1/Bali%20133-136.pdf

id	iium-53232
recordtype	eprints
spelling	iium-532322016-12-01T07:32:14Z http://irep.iium.edu.my/53232/ Antilipase and antioxidant activity of Phyllanthus niruri ethanolic extract Raja Abd. Rahman, Raja Noor Zaliha Alias, Norsyuhada Thean, Chor Leow Mohamad Ali, Mohd. Shukuri Ahmad Tajudin, Asilah Salleh, Abu Bakar RM Therapeutics. Pharmacology The aim of this study is to determine the antilipase and antioxidant activity of Phyllanthus niruri methanolic extract. The inhibitory activity against porcine pancreatic lipase (PPL) was determined by measuring the hydrolysis of p-nitrophenyl butyrate to p-nitrophenol at 405 nm. The crude extract exhibited strong lipase inhibitory activity with an IC50 value of 27. 65 µg/ mL. The inhibition mode study disclosed that P. niruri could act as noncompetitive inhibitor. Antioxidant activity of P. niruri extract was measured by 2, 2, diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity assay. P. niruri showed high antioxidant activity with an EC50 value of 7.471 µg/mL. The results suggested that P. niruri has shown potential as a source of natural antilipase and antioxidant. American-Eurasian Network for Scientific Information ( AENSI) 2015-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/53232/1/Bali%20133-136.pdf Raja Abd. Rahman, Raja Noor Zaliha and Alias, Norsyuhada and Thean, Chor Leow and Mohamad Ali, Mohd. Shukuri and Ahmad Tajudin, Asilah and Salleh, Abu Bakar (2015) Antilipase and antioxidant activity of Phyllanthus niruri ethanolic extract. Australian Journal of Basic and Applied Sciences, 9 (7). pp. 639-643. ISSN 1991-8178 http://ajbasweb.com/old/ajbas/2015/April/639-643.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RM Therapeutics. Pharmacology
spellingShingle	RM Therapeutics. Pharmacology Raja Abd. Rahman, Raja Noor Zaliha Alias, Norsyuhada Thean, Chor Leow Mohamad Ali, Mohd. Shukuri Ahmad Tajudin, Asilah Salleh, Abu Bakar Antilipase and antioxidant activity of Phyllanthus niruri ethanolic extract
description	The aim of this study is to determine the antilipase and antioxidant activity of Phyllanthus niruri methanolic extract. The inhibitory activity against porcine pancreatic lipase (PPL) was determined by measuring the hydrolysis of p-nitrophenyl butyrate to p-nitrophenol at 405 nm. The crude extract exhibited strong lipase inhibitory activity with an IC50 value of 27. 65 µg/ mL. The inhibition mode study disclosed that P. niruri could act as noncompetitive inhibitor. Antioxidant activity of P. niruri extract was measured by 2, 2, diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity assay. P. niruri showed high antioxidant activity with an EC50 value of 7.471 µg/mL. The results suggested that P. niruri has shown potential as a source of natural antilipase and antioxidant.
format	Article
author	Raja Abd. Rahman, Raja Noor Zaliha Alias, Norsyuhada Thean, Chor Leow Mohamad Ali, Mohd. Shukuri Ahmad Tajudin, Asilah Salleh, Abu Bakar
author_facet	Raja Abd. Rahman, Raja Noor Zaliha Alias, Norsyuhada Thean, Chor Leow Mohamad Ali, Mohd. Shukuri Ahmad Tajudin, Asilah Salleh, Abu Bakar
author_sort	Raja Abd. Rahman, Raja Noor Zaliha
title	Antilipase and antioxidant activity of Phyllanthus niruri ethanolic extract
title_short	Antilipase and antioxidant activity of Phyllanthus niruri ethanolic extract
title_full	Antilipase and antioxidant activity of Phyllanthus niruri ethanolic extract
title_fullStr	Antilipase and antioxidant activity of Phyllanthus niruri ethanolic extract
title_full_unstemmed	Antilipase and antioxidant activity of Phyllanthus niruri ethanolic extract
title_sort	antilipase and antioxidant activity of phyllanthus niruri ethanolic extract
publisher	American-Eurasian Network for Scientific Information ( AENSI)
publishDate	2015
url	http://irep.iium.edu.my/53232/ http://irep.iium.edu.my/53232/ http://irep.iium.edu.my/53232/1/Bali%20133-136.pdf
first_indexed	2023-09-18T21:15:22Z
last_indexed	2023-09-18T21:15:22Z
_version_	1777411526007717888

Antilipase and antioxidant activity of Phyllanthus niruri ethanolic extract

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