Pancreatic lipase inhibitory potential of selected Malaysian plants

Pancreatic lipase inhibitors from natural sources are considered as potential tool for the treatment of obesity. The inhibitory activity of 24 crude extracts of selected Malaysian plants against porcine pancreatic lipase (PPL) was successfully screened and tested by using in vitro approach. Orthosip...

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Main Authors:	Alias, Norsyuhada, Leow, Thean Chor, Mohamad Ali, Mohd. Shukuri, Ahmad Tajudin, Asilah, Salleh, Abu Bakar, Raja Abd. Rahman, Raja Noor Zaliha
Format:	Conference or Workshop Item
Language:	English
Published:	Universiti Kebangsaan Malaysia (UKM), Malaysia 2014
Subjects:	RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/53229/ http://irep.iium.edu.my/53229/1/ICNP2014%20Proceeding%20complete_53229.pdf

id	iium-53229
recordtype	eprints
spelling	iium-532292016-11-30T08:20:20Z http://irep.iium.edu.my/53229/ Pancreatic lipase inhibitory potential of selected Malaysian plants Alias, Norsyuhada Leow, Thean Chor Mohamad Ali, Mohd. Shukuri Ahmad Tajudin, Asilah Salleh, Abu Bakar Raja Abd. Rahman, Raja Noor Zaliha RM Therapeutics. Pharmacology Pancreatic lipase inhibitors from natural sources are considered as potential tool for the treatment of obesity. The inhibitory activity of 24 crude extracts of selected Malaysian plants against porcine pancreatic lipase (PPL) was successfully screened and tested by using in vitro approach. Orthosiphon stamineus, Phyllanthus niruri, Murraya paniculata and Averrhoa bilimbi leaves extracts showed more than 70% inhibitions when incubated with PPL at a final concentration of 500 μg/mL for 15 minutes at 37⁰C. P. niruri crude extract exhibited strongest lipase inhibitory activity, with an IC50 value of 27. 65 μg/mL followed by O. stamineus, M. paniculata and A. bilimbi with IC50 values of 34.74, 41.45 and 55.18 μg/mL, respectively. Inhibition mode study disclosed that O. stamineus and A. bilimbi could act as uncompetitive inhibitor while P. niruri and M. paniculata could act as noncompetitive inhibitor. The results suggested that these four plant extracts may be useful for obesity treatment. Universiti Kebangsaan Malaysia (UKM), Malaysia 2014-03 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/53229/1/ICNP2014%20Proceeding%20complete_53229.pdf Alias, Norsyuhada and Leow, Thean Chor and Mohamad Ali, Mohd. Shukuri and Ahmad Tajudin, Asilah and Salleh, Abu Bakar and Raja Abd. Rahman, Raja Noor Zaliha (2014) Pancreatic lipase inhibitory potential of selected Malaysian plants. In: International Conference on Natural Products 2014, Palm Garden Hotel, Putrajaya, Malaysia.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RM Therapeutics. Pharmacology
spellingShingle	RM Therapeutics. Pharmacology Alias, Norsyuhada Leow, Thean Chor Mohamad Ali, Mohd. Shukuri Ahmad Tajudin, Asilah Salleh, Abu Bakar Raja Abd. Rahman, Raja Noor Zaliha Pancreatic lipase inhibitory potential of selected Malaysian plants
description	Pancreatic lipase inhibitors from natural sources are considered as potential tool for the treatment of obesity. The inhibitory activity of 24 crude extracts of selected Malaysian plants against porcine pancreatic lipase (PPL) was successfully screened and tested by using in vitro approach. Orthosiphon stamineus, Phyllanthus niruri, Murraya paniculata and Averrhoa bilimbi leaves extracts showed more than 70% inhibitions when incubated with PPL at a final concentration of 500 μg/mL for 15 minutes at 37⁰C. P. niruri crude extract exhibited strongest lipase inhibitory activity, with an IC50 value of 27. 65 μg/mL followed by O. stamineus, M. paniculata and A. bilimbi with IC50 values of 34.74, 41.45 and 55.18 μg/mL, respectively. Inhibition mode study disclosed that O. stamineus and A. bilimbi could act as uncompetitive inhibitor while P. niruri and M. paniculata could act as noncompetitive inhibitor. The results suggested that these four plant extracts may be useful for obesity treatment.
format	Conference or Workshop Item
author	Alias, Norsyuhada Leow, Thean Chor Mohamad Ali, Mohd. Shukuri Ahmad Tajudin, Asilah Salleh, Abu Bakar Raja Abd. Rahman, Raja Noor Zaliha
author_facet	Alias, Norsyuhada Leow, Thean Chor Mohamad Ali, Mohd. Shukuri Ahmad Tajudin, Asilah Salleh, Abu Bakar Raja Abd. Rahman, Raja Noor Zaliha
author_sort	Alias, Norsyuhada
title	Pancreatic lipase inhibitory potential of selected Malaysian plants
title_short	Pancreatic lipase inhibitory potential of selected Malaysian plants
title_full	Pancreatic lipase inhibitory potential of selected Malaysian plants
title_fullStr	Pancreatic lipase inhibitory potential of selected Malaysian plants
title_full_unstemmed	Pancreatic lipase inhibitory potential of selected Malaysian plants
title_sort	pancreatic lipase inhibitory potential of selected malaysian plants
publisher	Universiti Kebangsaan Malaysia (UKM), Malaysia
publishDate	2014
url	http://irep.iium.edu.my/53229/ http://irep.iium.edu.my/53229/1/ICNP2014%20Proceeding%20complete_53229.pdf
first_indexed	2023-09-18T21:15:21Z
last_indexed	2023-09-18T21:15:21Z
_version_	1777411525860917248

Pancreatic lipase inhibitory potential of selected Malaysian plants

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