Evaluation of Drug Dosing in Renal Failure

Introduction: Rapid accumulation and toxicity can be developed if drugs dosages are not adjusted in patients with chronic kidney diseases (CKD). Objectives: To evaluate the prevalence of correct dosing in chronic kidney diseases depending on renal function estimation. Study Design: A cross-section...

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Main Authors:	Hammad, Mohamed A., Khamis, Ahmed A., Al-Akhali, Khaled M., Ali, Tarek M., Alasmri, Ashwag M., Al-Ahmari, Eman M., Mossa, Enas M, Al-Gahtani, Nada M., El-Sobky, Yasmin
Format:	Article
Language:	English
Published:	International Organization of Scientific Research (IOSR) 2016
Subjects:	RM300 Drugs and their action RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/53142/ http://irep.iium.edu.my/53142/ http://irep.iium.edu.my/53142/1/166002-Evaluation-of-Drug-Dosing-in-Renal-Failure-18-Oct-2016.pdf

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spelling	iium-531422017-01-17T08:17:32Z http://irep.iium.edu.my/53142/ Evaluation of Drug Dosing in Renal Failure Hammad, Mohamed A. Khamis, Ahmed A. Al-Akhali, Khaled M. Ali, Tarek M. Alasmri, Ashwag M. Al-Ahmari, Eman M. Mossa, Enas M Al-Gahtani, Nada M. El-Sobky, Yasmin RM300 Drugs and their action RS Pharmacy and materia medica Introduction: Rapid accumulation and toxicity can be developed if drugs dosages are not adjusted in patients with chronic kidney diseases (CKD). Objectives: To evaluate the prevalence of correct dosing in chronic kidney diseases depending on renal function estimation. Study Design: A cross-sectional observational study involving patients in medical ward from January to July 2014 at Aseer Central Hospital in Abha, Kingdom of Saudi Arabia Methods: Demographic data were collected from patients, patients' files and healthcare providers. Dosage adjustment depends on the patients’ kidney function, most often estimated by the patient's glomerular filtration rate (eGFR) calculated by the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) and a computerized system was used to determine the adjusted renal dose. Results: From total 2470 prescribed drugs for 500 inpatients, 420 (17%) drugs need a dosing adjustment in chronic renal failure and 2050 (83%) drugs do not need. From the 420 drugs that need a dosing adjustment, the dose of 202 (48.1%) drugs were adjusted, and of 218 (51.9%) drugs were not. Drugs that need a readjustment are allopurinol, ampicillin, cefepime, cefixime, ceftazidime, ceftriaxone, gentamycin, levofloxacin, meropenem, metoclopramide, metronidazole, ranitidine, rosuvastatin, tazocin, tienam and vancomycin. Conclusions: The dosing of more than half of the medications that need dosing adjustment in CKD were not adjusted which can increase the side effects and toxicity of these drugs for CKD patients. It is the pharmacist duty by co-operation with the medical team to ensure the prescribing of optimal dose. Keywords: Aseer Central Hospital, Chronic kidney disease, chronic renal failure, glomerular filtration rate, dialysis, dosing adjustment, Renal dysfunction, Renal impairment. International Organization of Scientific Research (IOSR) 2016 Article PeerReviewed application/pdf en http://irep.iium.edu.my/53142/1/166002-Evaluation-of-Drug-Dosing-in-Renal-Failure-18-Oct-2016.pdf Hammad, Mohamed A. and Khamis, Ahmed A. and Al-Akhali, Khaled M. and Ali, Tarek M. and Alasmri, Ashwag M. and Al-Ahmari, Eman M. and Mossa, Enas M and Al-Gahtani, Nada M. and El-Sobky, Yasmin (2016) Evaluation of Drug Dosing in Renal Failure. IOSR Journal of Pharmacy and Biological Sciences, 11 (5 ver III). pp. 39-50. ISSN 2319-7676 E-ISSN 2278-3008 http://www.iosrjournals.org/iosr-jpbs.html#
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RM300 Drugs and their action RS Pharmacy and materia medica
spellingShingle	RM300 Drugs and their action RS Pharmacy and materia medica Hammad, Mohamed A. Khamis, Ahmed A. Al-Akhali, Khaled M. Ali, Tarek M. Alasmri, Ashwag M. Al-Ahmari, Eman M. Mossa, Enas M Al-Gahtani, Nada M. El-Sobky, Yasmin Evaluation of Drug Dosing in Renal Failure
description	Introduction: Rapid accumulation and toxicity can be developed if drugs dosages are not adjusted in patients with chronic kidney diseases (CKD). Objectives: To evaluate the prevalence of correct dosing in chronic kidney diseases depending on renal function estimation. Study Design: A cross-sectional observational study involving patients in medical ward from January to July 2014 at Aseer Central Hospital in Abha, Kingdom of Saudi Arabia Methods: Demographic data were collected from patients, patients' files and healthcare providers. Dosage adjustment depends on the patients’ kidney function, most often estimated by the patient's glomerular filtration rate (eGFR) calculated by the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) and a computerized system was used to determine the adjusted renal dose. Results: From total 2470 prescribed drugs for 500 inpatients, 420 (17%) drugs need a dosing adjustment in chronic renal failure and 2050 (83%) drugs do not need. From the 420 drugs that need a dosing adjustment, the dose of 202 (48.1%) drugs were adjusted, and of 218 (51.9%) drugs were not. Drugs that need a readjustment are allopurinol, ampicillin, cefepime, cefixime, ceftazidime, ceftriaxone, gentamycin, levofloxacin, meropenem, metoclopramide, metronidazole, ranitidine, rosuvastatin, tazocin, tienam and vancomycin. Conclusions: The dosing of more than half of the medications that need dosing adjustment in CKD were not adjusted which can increase the side effects and toxicity of these drugs for CKD patients. It is the pharmacist duty by co-operation with the medical team to ensure the prescribing of optimal dose. Keywords: Aseer Central Hospital, Chronic kidney disease, chronic renal failure, glomerular filtration rate, dialysis, dosing adjustment, Renal dysfunction, Renal impairment.
format	Article
author	Hammad, Mohamed A. Khamis, Ahmed A. Al-Akhali, Khaled M. Ali, Tarek M. Alasmri, Ashwag M. Al-Ahmari, Eman M. Mossa, Enas M Al-Gahtani, Nada M. El-Sobky, Yasmin
author_facet	Hammad, Mohamed A. Khamis, Ahmed A. Al-Akhali, Khaled M. Ali, Tarek M. Alasmri, Ashwag M. Al-Ahmari, Eman M. Mossa, Enas M Al-Gahtani, Nada M. El-Sobky, Yasmin
author_sort	Hammad, Mohamed A.
title	Evaluation of Drug Dosing in Renal Failure
title_short	Evaluation of Drug Dosing in Renal Failure
title_full	Evaluation of Drug Dosing in Renal Failure
title_fullStr	Evaluation of Drug Dosing in Renal Failure
title_full_unstemmed	Evaluation of Drug Dosing in Renal Failure
title_sort	evaluation of drug dosing in renal failure
publisher	International Organization of Scientific Research (IOSR)
publishDate	2016
url	http://irep.iium.edu.my/53142/ http://irep.iium.edu.my/53142/ http://irep.iium.edu.my/53142/1/166002-Evaluation-of-Drug-Dosing-in-Renal-Failure-18-Oct-2016.pdf
first_indexed	2023-09-18T21:15:14Z
last_indexed	2023-09-18T21:15:14Z
_version_	1777411517663150080

Evaluation of Drug Dosing in Renal Failure

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