Dose and duration of opioid use in patients with cancer and noncancer pain at an outpatient hospital setting in Malaysia

Background: There is currently limited data available on the patterns of opioid prescribing in Malaysia. This study investigated the patterns of opioid prescribing and characterized the dosing and duration of opioid use in patients with noncancer and cancer pain. Method: This retrospective cros...

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Main Authors:	Zin, Che Suraya, Ab Rahman, Norny Syafinaz, Ismail, Che R., Leong, W. Choy
Format:	Article
Language:	English English
Published:	Wiley-Blackwell Publishing Ltd 2016
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/52565/ http://irep.iium.edu.my/52565/ http://irep.iium.edu.my/52565/ http://irep.iium.edu.my/52565/1/Zin_dose%20and%20duration_10.1111-papr.12525.pdf http://irep.iium.edu.my/52565/7/Dose%20and%20duration%20of%20opioid%20use%20in%20patients%20with%20cancer%20and%20noncancer%20pain%20at%20an%20outpatient%20hospital%20setting%20in%20Malaysia.pdf

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spelling	iium-525652018-04-18T07:00:26Z http://irep.iium.edu.my/52565/ Dose and duration of opioid use in patients with cancer and noncancer pain at an outpatient hospital setting in Malaysia Zin, Che Suraya Ab Rahman, Norny Syafinaz Ismail, Che R. Leong, W. Choy, RS Pharmacy and materia medica Background: There is currently limited data available on the patterns of opioid prescribing in Malaysia. This study investigated the patterns of opioid prescribing and characterized the dosing and duration of opioid use in patients with noncancer and cancer pain. Method: This retrospective cross sectional study was conducted at an outpatient hospital setting in Malaysia. All prescriptions for opioids (dihydrocodeine, fentanyl, morphine and oxycodone) issued between January 2013 and December 2014 were examined. The number of prescriptions and patients, the distribution of mean daily dose, annual total days covered with opioids, and annual total opioid dose at the individual level were calculated and stratified by noncancer and cancer groups. Results: A total of 1015 opioid prescriptions were prescribed for 347 patients from 2013 to 2014. Approximately 41.5% of patients (n=144/347) and 58.5% (n=203/347) were associated with noncancer and cancer diagnosis respectively. Oxycodone (38.0%) was the highest prescribed primarily for the noncancer group. Majority of patients in both noncancer (74.3%) and cancer (60.4%) groups were receiving mean daily doses of <50 mg morphine equivalents. The chronic use of opioid (>90 days per year) was associated with 21.8% of patients in the noncancer group and 17.5% in the cancer group. Conclusions: The finding from this study showed that 41.5% of opioid users at an outpatient hospital setting in Malaysia received opioids for noncancer pain and 21.8% of these users were using opioid for longer than 90 days. The average daily dose in majority of patients in both groups of noncancer and cancer is modest. Wiley-Blackwell Publishing Ltd 2016-10-25 Article PeerReviewed application/pdf en http://irep.iium.edu.my/52565/1/Zin_dose%20and%20duration_10.1111-papr.12525.pdf application/pdf en http://irep.iium.edu.my/52565/7/Dose%20and%20duration%20of%20opioid%20use%20in%20patients%20with%20cancer%20and%20noncancer%20pain%20at%20an%20outpatient%20hospital%20setting%20in%20Malaysia.pdf Zin, Che Suraya and Ab Rahman, Norny Syafinaz and Ismail, Che R. and Leong, W. Choy, (2016) Dose and duration of opioid use in patients with cancer and noncancer pain at an outpatient hospital setting in Malaysia. Pain Practice, 17 (6). pp. 774-781. ISSN 1530-7085 E-ISSN 1533-2500 (In Press) http://onlinelibrary.wiley.com/doi/10.1111/papr.12525/full 10.1111/papr.12525
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Zin, Che Suraya Ab Rahman, Norny Syafinaz Ismail, Che R. Leong, W. Choy, Dose and duration of opioid use in patients with cancer and noncancer pain at an outpatient hospital setting in Malaysia
description	Background: There is currently limited data available on the patterns of opioid prescribing in Malaysia. This study investigated the patterns of opioid prescribing and characterized the dosing and duration of opioid use in patients with noncancer and cancer pain. Method: This retrospective cross sectional study was conducted at an outpatient hospital setting in Malaysia. All prescriptions for opioids (dihydrocodeine, fentanyl, morphine and oxycodone) issued between January 2013 and December 2014 were examined. The number of prescriptions and patients, the distribution of mean daily dose, annual total days covered with opioids, and annual total opioid dose at the individual level were calculated and stratified by noncancer and cancer groups. Results: A total of 1015 opioid prescriptions were prescribed for 347 patients from 2013 to 2014. Approximately 41.5% of patients (n=144/347) and 58.5% (n=203/347) were associated with noncancer and cancer diagnosis respectively. Oxycodone (38.0%) was the highest prescribed primarily for the noncancer group. Majority of patients in both noncancer (74.3%) and cancer (60.4%) groups were receiving mean daily doses of <50 mg morphine equivalents. The chronic use of opioid (>90 days per year) was associated with 21.8% of patients in the noncancer group and 17.5% in the cancer group. Conclusions: The finding from this study showed that 41.5% of opioid users at an outpatient hospital setting in Malaysia received opioids for noncancer pain and 21.8% of these users were using opioid for longer than 90 days. The average daily dose in majority of patients in both groups of noncancer and cancer is modest.
format	Article
author	Zin, Che Suraya Ab Rahman, Norny Syafinaz Ismail, Che R. Leong, W. Choy,
author_facet	Zin, Che Suraya Ab Rahman, Norny Syafinaz Ismail, Che R. Leong, W. Choy,
author_sort	Zin, Che Suraya
title	Dose and duration of opioid use in patients with cancer and noncancer pain at an outpatient hospital setting in Malaysia
title_short	Dose and duration of opioid use in patients with cancer and noncancer pain at an outpatient hospital setting in Malaysia
title_full	Dose and duration of opioid use in patients with cancer and noncancer pain at an outpatient hospital setting in Malaysia
title_fullStr	Dose and duration of opioid use in patients with cancer and noncancer pain at an outpatient hospital setting in Malaysia
title_full_unstemmed	Dose and duration of opioid use in patients with cancer and noncancer pain at an outpatient hospital setting in Malaysia
title_sort	dose and duration of opioid use in patients with cancer and noncancer pain at an outpatient hospital setting in malaysia
publisher	Wiley-Blackwell Publishing Ltd
publishDate	2016
url	http://irep.iium.edu.my/52565/ http://irep.iium.edu.my/52565/ http://irep.iium.edu.my/52565/ http://irep.iium.edu.my/52565/1/Zin_dose%20and%20duration_10.1111-papr.12525.pdf http://irep.iium.edu.my/52565/7/Dose%20and%20duration%20of%20opioid%20use%20in%20patients%20with%20cancer%20and%20noncancer%20pain%20at%20an%20outpatient%20hospital%20setting%20in%20Malaysia.pdf
first_indexed	2023-09-18T21:14:27Z
last_indexed	2023-09-18T21:14:27Z
_version_	1777411468619153408

Dose and duration of opioid use in patients with cancer and noncancer pain at an outpatient hospital setting in Malaysia

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