Mathematical modeling of glucose-insulin system behavior in Hospital Tengku Ampuan Afzan intensive care unit patients

Mathematical modeling of glucose-insulin system is significantly important to understand the body regulation control, to analyze experimental data based on clinical trials, to identify and quantify relevant physiological parameters, to design proper clinical trials and to assess diabetes therapies....

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Main Authors:	Jamaludin, Ummu K., Suhaimi, Fatanah M., A. Razak, Normy N., Dzaharudin, Fatimah, Md Ralib, Azrina, Mat Nor, Mohd Basri
Format:	Article
Language:	English
Published:	ARPN (Asian Research Publishing Network) 2016
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/52499/ http://irep.iium.edu.my/52499/ http://irep.iium.edu.my/52499/7/52499.pdf

id	iium-52499
recordtype	eprints
spelling	iium-524992016-11-03T06:48:50Z http://irep.iium.edu.my/52499/ Mathematical modeling of glucose-insulin system behavior in Hospital Tengku Ampuan Afzan intensive care unit patients Jamaludin, Ummu K. Suhaimi, Fatanah M. A. Razak, Normy N. Dzaharudin, Fatimah Md Ralib, Azrina Mat Nor, Mohd Basri R Medicine (General) Mathematical modeling of glucose-insulin system is significantly important to understand the body regulation control, to analyze experimental data based on clinical trials, to identify and quantify relevant physiological parameters, to design proper clinical trials and to assess diabetes therapies. In general, critically ill patients with blood glucose concentrations between 10.0 to 12.2 mmol/l is identified to develop an acute hyperglycaemia or high blood glucose (BG). Thus, to monitor hyperglycaemia among critically ill patients, this study is focused on observing the glucose-insulin system behaviour based on 40 patients’ clinical data collected in Hospital Tengku Ampuan Afzan, Kuantan, Pahang with clinically validated mathematical glucose-insulin model. By using this model, a critical model-based parameter known as insulin sensitivity (SI) that illustrates patient’s severity were identified hourly for all patients whose on insulin infusion therapy protocol for average four to six days. The results show that a BG normal distribution is attained with median kurtosis of 2.72. While, the 40 patient-specific SI indicate that an outliers-prone distribution occurred as kurtosis 3.96. Thus, abrupt changes in SI is basically due to chaotic interaction between blood glucose and insulin concentrations in bloodstreams. Also, the glucose-insulin behavior pattern among these 40 critically ill patients might be varied due to their main diagnotics illness such as acute kidney failure, cardiovascular disease, etc. Overall, these results might assist clinicians and researchers to understand the glucose-insulin behavior based on patient’s severity illness and helps to inform glycaemic control protocol development in a larger group of critically ill patients. ARPN (Asian Research Publishing Network) 2016-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/52499/7/52499.pdf Jamaludin, Ummu K. and Suhaimi, Fatanah M. and A. Razak, Normy N. and Dzaharudin, Fatimah and Md Ralib, Azrina and Mat Nor, Mohd Basri (2016) Mathematical modeling of glucose-insulin system behavior in Hospital Tengku Ampuan Afzan intensive care unit patients. ARPN Journal of Engineering and Applied Sciences, 11 (18). 10899 -10903. ISSN 1819-6608 http://www.arpnjournals.org/jeas/research_papers/rp_2016/jeas_0916_5006.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Jamaludin, Ummu K. Suhaimi, Fatanah M. A. Razak, Normy N. Dzaharudin, Fatimah Md Ralib, Azrina Mat Nor, Mohd Basri Mathematical modeling of glucose-insulin system behavior in Hospital Tengku Ampuan Afzan intensive care unit patients
description	Mathematical modeling of glucose-insulin system is significantly important to understand the body regulation control, to analyze experimental data based on clinical trials, to identify and quantify relevant physiological parameters, to design proper clinical trials and to assess diabetes therapies. In general, critically ill patients with blood glucose concentrations between 10.0 to 12.2 mmol/l is identified to develop an acute hyperglycaemia or high blood glucose (BG). Thus, to monitor hyperglycaemia among critically ill patients, this study is focused on observing the glucose-insulin system behaviour based on 40 patients’ clinical data collected in Hospital Tengku Ampuan Afzan, Kuantan, Pahang with clinically validated mathematical glucose-insulin model. By using this model, a critical model-based parameter known as insulin sensitivity (SI) that illustrates patient’s severity were identified hourly for all patients whose on insulin infusion therapy protocol for average four to six days. The results show that a BG normal distribution is attained with median kurtosis of 2.72. While, the 40 patient-specific SI indicate that an outliers-prone distribution occurred as kurtosis 3.96. Thus, abrupt changes in SI is basically due to chaotic interaction between blood glucose and insulin concentrations in bloodstreams. Also, the glucose-insulin behavior pattern among these 40 critically ill patients might be varied due to their main diagnotics illness such as acute kidney failure, cardiovascular disease, etc. Overall, these results might assist clinicians and researchers to understand the glucose-insulin behavior based on patient’s severity illness and helps to inform glycaemic control protocol development in a larger group of critically ill patients.
format	Article
author	Jamaludin, Ummu K. Suhaimi, Fatanah M. A. Razak, Normy N. Dzaharudin, Fatimah Md Ralib, Azrina Mat Nor, Mohd Basri
author_facet	Jamaludin, Ummu K. Suhaimi, Fatanah M. A. Razak, Normy N. Dzaharudin, Fatimah Md Ralib, Azrina Mat Nor, Mohd Basri
author_sort	Jamaludin, Ummu K.
title	Mathematical modeling of glucose-insulin system behavior in Hospital Tengku Ampuan Afzan intensive care unit patients
title_short	Mathematical modeling of glucose-insulin system behavior in Hospital Tengku Ampuan Afzan intensive care unit patients
title_full	Mathematical modeling of glucose-insulin system behavior in Hospital Tengku Ampuan Afzan intensive care unit patients
title_fullStr	Mathematical modeling of glucose-insulin system behavior in Hospital Tengku Ampuan Afzan intensive care unit patients
title_full_unstemmed	Mathematical modeling of glucose-insulin system behavior in Hospital Tengku Ampuan Afzan intensive care unit patients
title_sort	mathematical modeling of glucose-insulin system behavior in hospital tengku ampuan afzan intensive care unit patients
publisher	ARPN (Asian Research Publishing Network)
publishDate	2016
url	http://irep.iium.edu.my/52499/ http://irep.iium.edu.my/52499/ http://irep.iium.edu.my/52499/7/52499.pdf
first_indexed	2023-09-18T21:14:22Z
last_indexed	2023-09-18T21:14:22Z
_version_	1777411463960330240

Mathematical modeling of glucose-insulin system behavior in Hospital Tengku Ampuan Afzan intensive care unit patients

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