Factors associated with prescription opioid overdose deaths in patients with non-cancer pain: A literature review

Introduction: Opioid analgesics have increasingly been prescribed in the treatment of non -cancer pain and this trend has accompanied increasing rates of opioid overdose deaths (ODs). Little is known about the factors that may predispose an individual to being at risk for fatal overdose from prescr...

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Main Authors:	Ismail, Fadhilah, Zin, Che Suraya
Format:	Conference or Workshop Item
Language:	English English
Published:	2015
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/52346/ http://irep.iium.edu.my/52346/1/1601017__%20poster_MPS_all.pdf http://irep.iium.edu.my/52346/7/52346.pdf

id	iium-52346
recordtype	eprints
spelling	iium-523462016-10-18T02:04:28Z http://irep.iium.edu.my/52346/ Factors associated with prescription opioid overdose deaths in patients with non-cancer pain: A literature review Ismail, Fadhilah Zin, Che Suraya RS Pharmacy and materia medica Introduction: Opioid analgesics have increasingly been prescribed in the treatment of non -cancer pain and this trend has accompanied increasing rates of opioid overdose deaths (ODs). Little is known about the factors that may predispose an individual to being at risk for fatal overdose from prescription opioids. Objective: This review examined factors associated with prescription opioid overdose deaths in patients with non-cancer pain. Method: A comprehensive literature search was conducted for studies published from 2004 to 2014 using databases such as Science Direct, PubMed, Web of Science, Cochrane review and Scopus. Articles were included if they were original research studies written in English that reported deaths with prescription opioid overdose in patients with non-cancer pain. Results: A total of 18 studies met the inclusion criteria and were included. Fndings from the review demonstrated that concomitant use of opioids with benzodiazepines (polysubstance use) was the main factor associated with opioid ODs. Codeine and oxycodone were more commonly reported to cause opioid ODs and opioid doses of more than 100 mg per day in morphine equivalents have higher risk to cause ODs. Other factors included male patients, middle aged and having mental illness. Conclusion: Prescription opioid overdose deaths were primarily caused by concomitant use of opioid with benzodiazepines. Further research is required to examine the trend and patterns of this co-prescribing. The guidelines on opioid prescribing and education on opioids for both patients and physicians should be emphasized to reduce fatalities from overdose while enhancing the safe prescribing of opioids. 2015 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/52346/1/1601017__%20poster_MPS_all.pdf application/pdf en http://irep.iium.edu.my/52346/7/52346.pdf Ismail, Fadhilah and Zin, Che Suraya (2015) Factors associated with prescription opioid overdose deaths in patients with non-cancer pain: A literature review. In: 12th MPS Pharmacy Scientific Conference 2015 (MPS-PSC 2015), 13th-15th November 2015, Subang Jaya, Selangor. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Ismail, Fadhilah Zin, Che Suraya Factors associated with prescription opioid overdose deaths in patients with non-cancer pain: A literature review
description	Introduction: Opioid analgesics have increasingly been prescribed in the treatment of non -cancer pain and this trend has accompanied increasing rates of opioid overdose deaths (ODs). Little is known about the factors that may predispose an individual to being at risk for fatal overdose from prescription opioids. Objective: This review examined factors associated with prescription opioid overdose deaths in patients with non-cancer pain. Method: A comprehensive literature search was conducted for studies published from 2004 to 2014 using databases such as Science Direct, PubMed, Web of Science, Cochrane review and Scopus. Articles were included if they were original research studies written in English that reported deaths with prescription opioid overdose in patients with non-cancer pain. Results: A total of 18 studies met the inclusion criteria and were included. Fndings from the review demonstrated that concomitant use of opioids with benzodiazepines (polysubstance use) was the main factor associated with opioid ODs. Codeine and oxycodone were more commonly reported to cause opioid ODs and opioid doses of more than 100 mg per day in morphine equivalents have higher risk to cause ODs. Other factors included male patients, middle aged and having mental illness. Conclusion: Prescription opioid overdose deaths were primarily caused by concomitant use of opioid with benzodiazepines. Further research is required to examine the trend and patterns of this co-prescribing. The guidelines on opioid prescribing and education on opioids for both patients and physicians should be emphasized to reduce fatalities from overdose while enhancing the safe prescribing of opioids.
format	Conference or Workshop Item
author	Ismail, Fadhilah Zin, Che Suraya
author_facet	Ismail, Fadhilah Zin, Che Suraya
author_sort	Ismail, Fadhilah
title	Factors associated with prescription opioid overdose deaths in patients with non-cancer pain: A literature review
title_short	Factors associated with prescription opioid overdose deaths in patients with non-cancer pain: A literature review
title_full	Factors associated with prescription opioid overdose deaths in patients with non-cancer pain: A literature review
title_fullStr	Factors associated with prescription opioid overdose deaths in patients with non-cancer pain: A literature review
title_full_unstemmed	Factors associated with prescription opioid overdose deaths in patients with non-cancer pain: A literature review
title_sort	factors associated with prescription opioid overdose deaths in patients with non-cancer pain: a literature review
publishDate	2015
url	http://irep.iium.edu.my/52346/ http://irep.iium.edu.my/52346/1/1601017__%20poster_MPS_all.pdf http://irep.iium.edu.my/52346/7/52346.pdf
first_indexed	2023-09-18T21:14:10Z
last_indexed	2023-09-18T21:14:10Z
_version_	1777411450840547328

Factors associated with prescription opioid overdose deaths in patients with non-cancer pain: A literature review

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