Differential patterns of persistent opioid use in patients with cancer and non-cancer pain

OBJECTIVES: This study aims to evaluate different patterns of persistent opioid use in patients with cancer and non-cancer pain. METHODS: This cross sectional study was conducted at an outpatient pharmacy Hospital Tengku Ampuan Afzan Kuantan (HTAA) Malaysia. Prescription records for four opioids...

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Main Authors:	Abdullah Sani, Asween Rowena, Zin, Che Suraya, Mohamad Noor, Zaswiza, Mohamed, Abdul Hadi, Nissen, Lisa M.
Format:	Conference or Workshop Item
Language:	English English English English
Published:	Elsevier 2016
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/52344/ http://irep.iium.edu.my/52344/ http://irep.iium.edu.my/52344/ http://irep.iium.edu.my/52344/7/52344.pdf http://irep.iium.edu.my/52344/13/52344_differential%20patterns.pdf http://irep.iium.edu.my/52344/14/52344_Differential%20patterns_TOC.pdf http://irep.iium.edu.my/52344/24/52344_Differential%20patterns%20of%20persistent%20opioid_WoS.pdf

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recordtype	eprints
spelling	iium-523442017-10-03T09:41:55Z http://irep.iium.edu.my/52344/ Differential patterns of persistent opioid use in patients with cancer and non-cancer pain Abdullah Sani, Asween Rowena Zin, Che Suraya Mohamad Noor, Zaswiza Mohamed, Abdul Hadi Nissen, Lisa M. RS Pharmacy and materia medica OBJECTIVES: This study aims to evaluate different patterns of persistent opioid use in patients with cancer and non-cancer pain. METHODS: This cross sectional study was conducted at an outpatient pharmacy Hospital Tengku Ampuan Afzan Kuantan (HTAA) Malaysia. Prescription records for four opioids (dihydrocodeine, fentanyl, morphine and oxycodone) issued between January 2013 and December 2014 were examined. Persistence pattern is defined based on different levels of dispensed opioid amounts, number of prescriptions and the number of quarters out of the year in which prescriptions were dispensed. The strict definition describes a typical patient using opioids to achieve a continuous serum concentration in the therapeutic range, the intermediate definition represents a typical patient using opioid daily but not around the clock and the wide definition describes a typical patient who uses opioids most of the day. Patients who did not meet any of the definitions were categorized as non-persistent. Number of patients for each persistence group was calculated and all analyses were performed using Stata 13 (Stata Corp LP, Texas, USA). RESULTS: A total of 1,684 opioid prescriptions for 379 patients were dispensed during the study period. Seventy five percent of (n=283/379) patients were associated with cancer diagnosis while 25% (n=96/379) with non-cancer diagnosis. The prevalence of persistent opioid users was higher in the non-cancer group (13.5%) compared to the cancer group (9.9%). The prevalence of strict, intermediate, and wide definitions were (23.1% vs. 28.6%), (15.4% vs 10.7%), and (61.5% vs 60.7%) in the non-cancer and cancer groups respectively. CONCLUSIONS: Persistent opioid users were more prevalent in the non-cancer group with the majority in the wide and intermediate persistence patterns. Further investigation is required to examine the clinical outcomes related to differential patterns of persistence. Elsevier 2016 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/52344/7/52344.pdf application/pdf en http://irep.iium.edu.my/52344/13/52344_differential%20patterns.pdf application/pdf en http://irep.iium.edu.my/52344/14/52344_Differential%20patterns_TOC.pdf application/pdf en http://irep.iium.edu.my/52344/24/52344_Differential%20patterns%20of%20persistent%20opioid_WoS.pdf Abdullah Sani, Asween Rowena and Zin, Che Suraya and Mohamad Noor, Zaswiza and Mohamed, Abdul Hadi and Nissen, Lisa M. (2016) Differential patterns of persistent opioid use in patients with cancer and non-cancer pain. In: ISPOR 7th Asia Pacific Conference, 3-6 September 2016, Singapore. http://www.ispor.org/event/index/2016singapore http://doi.org/10.1016/j.jval.2016.08.690
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Abdullah Sani, Asween Rowena Zin, Che Suraya Mohamad Noor, Zaswiza Mohamed, Abdul Hadi Nissen, Lisa M. Differential patterns of persistent opioid use in patients with cancer and non-cancer pain
description	OBJECTIVES: This study aims to evaluate different patterns of persistent opioid use in patients with cancer and non-cancer pain. METHODS: This cross sectional study was conducted at an outpatient pharmacy Hospital Tengku Ampuan Afzan Kuantan (HTAA) Malaysia. Prescription records for four opioids (dihydrocodeine, fentanyl, morphine and oxycodone) issued between January 2013 and December 2014 were examined. Persistence pattern is defined based on different levels of dispensed opioid amounts, number of prescriptions and the number of quarters out of the year in which prescriptions were dispensed. The strict definition describes a typical patient using opioids to achieve a continuous serum concentration in the therapeutic range, the intermediate definition represents a typical patient using opioid daily but not around the clock and the wide definition describes a typical patient who uses opioids most of the day. Patients who did not meet any of the definitions were categorized as non-persistent. Number of patients for each persistence group was calculated and all analyses were performed using Stata 13 (Stata Corp LP, Texas, USA). RESULTS: A total of 1,684 opioid prescriptions for 379 patients were dispensed during the study period. Seventy five percent of (n=283/379) patients were associated with cancer diagnosis while 25% (n=96/379) with non-cancer diagnosis. The prevalence of persistent opioid users was higher in the non-cancer group (13.5%) compared to the cancer group (9.9%). The prevalence of strict, intermediate, and wide definitions were (23.1% vs. 28.6%), (15.4% vs 10.7%), and (61.5% vs 60.7%) in the non-cancer and cancer groups respectively. CONCLUSIONS: Persistent opioid users were more prevalent in the non-cancer group with the majority in the wide and intermediate persistence patterns. Further investigation is required to examine the clinical outcomes related to differential patterns of persistence.
format	Conference or Workshop Item
author	Abdullah Sani, Asween Rowena Zin, Che Suraya Mohamad Noor, Zaswiza Mohamed, Abdul Hadi Nissen, Lisa M.
author_facet	Abdullah Sani, Asween Rowena Zin, Che Suraya Mohamad Noor, Zaswiza Mohamed, Abdul Hadi Nissen, Lisa M.
author_sort	Abdullah Sani, Asween Rowena
title	Differential patterns of persistent opioid use in patients with cancer and non-cancer pain
title_short	Differential patterns of persistent opioid use in patients with cancer and non-cancer pain
title_full	Differential patterns of persistent opioid use in patients with cancer and non-cancer pain
title_fullStr	Differential patterns of persistent opioid use in patients with cancer and non-cancer pain
title_full_unstemmed	Differential patterns of persistent opioid use in patients with cancer and non-cancer pain
title_sort	differential patterns of persistent opioid use in patients with cancer and non-cancer pain
publisher	Elsevier
publishDate	2016
url	http://irep.iium.edu.my/52344/ http://irep.iium.edu.my/52344/ http://irep.iium.edu.my/52344/ http://irep.iium.edu.my/52344/7/52344.pdf http://irep.iium.edu.my/52344/13/52344_differential%20patterns.pdf http://irep.iium.edu.my/52344/14/52344_Differential%20patterns_TOC.pdf http://irep.iium.edu.my/52344/24/52344_Differential%20patterns%20of%20persistent%20opioid_WoS.pdf
first_indexed	2023-09-18T21:14:10Z
last_indexed	2023-09-18T21:14:10Z
_version_	1777411450551140352

Differential patterns of persistent opioid use in patients with cancer and non-cancer pain

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