Cytotoxicity of triterpenes from the leaves of Garcinia prainiana King (Guttiferae)

Phytochemical investigation of the leaves of Garcinia prainiana resulted in the isolation of five triterpenes identified as squalene 1, friedelin 2, lupeol 3, 3β-hydroxyeupha-5,22-diene 4, and 3β-acetoxyeupha-5,22-diene 5. The structures of these compounds were established by analysis of their spect...

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Main Authors:	On, Shamsul, Wan Salleh, Wan Mohd Nuzul Hakimi, Ahmad, Farediah, Sirat, Hasnah M, Bakhtiar, M. Taher
Format:	Article
Language:	English English English
Published:	Marmara University 2017
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/52129/ http://irep.iium.edu.my/52129/ http://irep.iium.edu.my/52129/ http://irep.iium.edu.my/52129/1/52129_Cytotoxicity%20of%20triterpenes.pdf http://irep.iium.edu.my/52129/7/52129_Cytotoxicity%20of%20triterpenes%20from%20the%20leaves_SCOPUS.pdf http://irep.iium.edu.my/52129/8/52129_Cytotoxicity%20of%20triterpenes%20from%20the%20leaves_WOS.pdf

id	iium-52129
recordtype	eprints
spelling	iium-521292018-04-17T07:27:13Z http://irep.iium.edu.my/52129/ Cytotoxicity of triterpenes from the leaves of Garcinia prainiana King (Guttiferae) On, Shamsul Wan Salleh, Wan Mohd Nuzul Hakimi Ahmad, Farediah Sirat, Hasnah M Bakhtiar, M. Taher RS Pharmacy and materia medica Phytochemical investigation of the leaves of Garcinia prainiana resulted in the isolation of five triterpenes identified as squalene 1, friedelin 2, lupeol 3, 3β-hydroxyeupha-5,22-diene 4, and 3β-acetoxyeupha-5,22-diene 5. The structures of these compounds were established by analysis of their spectroscopic data, as compared to that of reported compounds. All compounds were tested for cytotoxicity against H1299 and A549 lung cancer cell lines using MTT assay. 3β-Acetoxyeupha-5,22-diene 5 exhibited the most significant activity against human non-small cell lung carcinoma cell lines, H1299 and A549 with IC50 values 18.0 μg/ml and 36.3 μg/ml, respectively. Marmara University 2017 Article PeerReviewed application/pdf en http://irep.iium.edu.my/52129/1/52129_Cytotoxicity%20of%20triterpenes.pdf application/pdf en http://irep.iium.edu.my/52129/7/52129_Cytotoxicity%20of%20triterpenes%20from%20the%20leaves_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/52129/8/52129_Cytotoxicity%20of%20triterpenes%20from%20the%20leaves_WOS.pdf On, Shamsul and Wan Salleh, Wan Mohd Nuzul Hakimi and Ahmad, Farediah and Sirat, Hasnah M and Bakhtiar, M. Taher (2017) Cytotoxicity of triterpenes from the leaves of Garcinia prainiana King (Guttiferae). Marmara Pharmaceutical Journal: an international peer-reveiwed open acces journal of pharmacy and pharmaceutical sciences., 21 (1). pp. 127-131. ISSN 1309-0801 http://e-dergi.marmara.edu.tr/marupj/article/view/5000194174/5000173549 10.12991/marupj.259890
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica On, Shamsul Wan Salleh, Wan Mohd Nuzul Hakimi Ahmad, Farediah Sirat, Hasnah M Bakhtiar, M. Taher Cytotoxicity of triterpenes from the leaves of Garcinia prainiana King (Guttiferae)
description	Phytochemical investigation of the leaves of Garcinia prainiana resulted in the isolation of five triterpenes identified as squalene 1, friedelin 2, lupeol 3, 3β-hydroxyeupha-5,22-diene 4, and 3β-acetoxyeupha-5,22-diene 5. The structures of these compounds were established by analysis of their spectroscopic data, as compared to that of reported compounds. All compounds were tested for cytotoxicity against H1299 and A549 lung cancer cell lines using MTT assay. 3β-Acetoxyeupha-5,22-diene 5 exhibited the most significant activity against human non-small cell lung carcinoma cell lines, H1299 and A549 with IC50 values 18.0 μg/ml and 36.3 μg/ml, respectively.
format	Article
author	On, Shamsul Wan Salleh, Wan Mohd Nuzul Hakimi Ahmad, Farediah Sirat, Hasnah M Bakhtiar, M. Taher
author_facet	On, Shamsul Wan Salleh, Wan Mohd Nuzul Hakimi Ahmad, Farediah Sirat, Hasnah M Bakhtiar, M. Taher
author_sort	On, Shamsul
title	Cytotoxicity of triterpenes from the leaves of Garcinia prainiana King (Guttiferae)
title_short	Cytotoxicity of triterpenes from the leaves of Garcinia prainiana King (Guttiferae)
title_full	Cytotoxicity of triterpenes from the leaves of Garcinia prainiana King (Guttiferae)
title_fullStr	Cytotoxicity of triterpenes from the leaves of Garcinia prainiana King (Guttiferae)
title_full_unstemmed	Cytotoxicity of triterpenes from the leaves of Garcinia prainiana King (Guttiferae)
title_sort	cytotoxicity of triterpenes from the leaves of garcinia prainiana king (guttiferae)
publisher	Marmara University
publishDate	2017
url	http://irep.iium.edu.my/52129/ http://irep.iium.edu.my/52129/ http://irep.iium.edu.my/52129/ http://irep.iium.edu.my/52129/1/52129_Cytotoxicity%20of%20triterpenes.pdf http://irep.iium.edu.my/52129/7/52129_Cytotoxicity%20of%20triterpenes%20from%20the%20leaves_SCOPUS.pdf http://irep.iium.edu.my/52129/8/52129_Cytotoxicity%20of%20triterpenes%20from%20the%20leaves_WOS.pdf
first_indexed	2023-09-18T21:13:55Z
last_indexed	2023-09-18T21:13:55Z
_version_	1777411434944135168

Cytotoxicity of triterpenes from the leaves of Garcinia prainiana King (Guttiferae)

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