Cytotoxicity of triterpenes from the leaves of Garcinia prainiana King (Guttiferae)
Phytochemical investigation of the leaves of Garcinia prainiana resulted in the isolation of five triterpenes identified as squalene 1, friedelin 2, lupeol 3, 3β-hydroxyeupha-5,22-diene 4, and 3β-acetoxyeupha-5,22-diene 5. The structures of these compounds were established by analysis of their spect...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English English |
| Published: |
Marmara University
2017
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/52129/ http://irep.iium.edu.my/52129/ http://irep.iium.edu.my/52129/ http://irep.iium.edu.my/52129/1/52129_Cytotoxicity%20of%20triterpenes.pdf http://irep.iium.edu.my/52129/7/52129_Cytotoxicity%20of%20triterpenes%20from%20the%20leaves_SCOPUS.pdf http://irep.iium.edu.my/52129/8/52129_Cytotoxicity%20of%20triterpenes%20from%20the%20leaves_WOS.pdf |
| Summary: | Phytochemical investigation of the leaves of Garcinia prainiana resulted in the isolation of five triterpenes identified as squalene 1, friedelin 2, lupeol 3, 3β-hydroxyeupha-5,22-diene 4, and 3β-acetoxyeupha-5,22-diene 5. The structures of these compounds were established by analysis of their spectroscopic data, as compared to that of reported compounds. All compounds were tested for cytotoxicity against H1299 and A549 lung cancer cell lines using MTT assay. 3β-Acetoxyeupha-5,22-diene 5 exhibited the most significant activity against human non-small cell lung carcinoma cell lines, H1299 and A549 with
IC50 values 18.0 μg/ml and 36.3 μg/ml, respectively. |
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