Glidant effect of hydrophobic and hydrophilic nanosilica on a cohesivepowder: comparison of different flow characterization techniques

The methods used for flow characterization of a powder mass include the angle of repose (AOR), Carrindex (CI), and powder flow tester (PFT). The use of nanosilica as a flow modifier (glidant) is very com-mon in industry. This study aims to compare the glidant effect of hydrophobic and hydrophilic si...

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Main Authors:	Ruzaidi, Fahmi Ahmad, Mandal, Uttam Kumar, Chatterjee, Bappaditya
Format:	Article
Language:	English English English
Published:	Elsevier 2017
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/51875/ http://irep.iium.edu.my/51875/ http://irep.iium.edu.my/51875/ http://irep.iium.edu.my/51875/25/51875_Glidant%20effect%20of%20hydrophobic.pdf http://irep.iium.edu.my/51875/8/51875_Glidant%20effect%20of%20hydrophobic_SCOPUS.pdf http://irep.iium.edu.my/51875/9/51875_Glidant%20effect%20of%20hydrophobic_WOS.pdf

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spelling	iium-518752018-05-04T08:03:07Z http://irep.iium.edu.my/51875/ Glidant effect of hydrophobic and hydrophilic nanosilica on a cohesivepowder: comparison of different flow characterization techniques Ruzaidi, Fahmi Ahmad Mandal, Uttam Kumar Chatterjee, Bappaditya RS Pharmacy and materia medica The methods used for flow characterization of a powder mass include the angle of repose (AOR), Carrindex (CI), and powder flow tester (PFT). The use of nanosilica as a flow modifier (glidant) is very com-mon in industry. This study aims to compare the glidant effect of hydrophobic and hydrophilic silica ona poorly flowable active pharmaceutical ingredient (ibuprofen) by different flow characterization tech-niques. Different percentages (0.5, 1.0, and 2.0 wt%) of both types of mixed silica–ibuprofen powders wereevaluated by the AOR, CI, bulk density, and PFT. The flow factor, effective angle of friction, and cohesionwere determined to explain the bulk powder properties. The results show that different types of silicashow different levels of flow property improvement, but the techniques do not equally discriminate thedifferences. Hydrophobic silica results in better improvement of the flow property than hydrophilic silica,probably because of its better surface coverage of silica on the host particles. Change of the bulk densitywith applied pressure was significant for the different powders. This study demonstrates that combiningseveral characterization methods provides a better understanding of bulk powder flow properties withrespect to powder–process relationships than a single flow indicator Elsevier 2017-04-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/51875/25/51875_Glidant%20effect%20of%20hydrophobic.pdf application/pdf en http://irep.iium.edu.my/51875/8/51875_Glidant%20effect%20of%20hydrophobic_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/51875/9/51875_Glidant%20effect%20of%20hydrophobic_WOS.pdf Ruzaidi, Fahmi Ahmad and Mandal, Uttam Kumar and Chatterjee, Bappaditya (2017) Glidant effect of hydrophobic and hydrophilic nanosilica on a cohesivepowder: comparison of different flow characterization techniques. Particuology, 31. pp. 69-79. ISSN 1674-2001 E-ISSN 2210-4291 http://www.sciencedirect.com/science/article/pii/S1674200116300864 10.1016/j.partic.2016.04.006
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Ruzaidi, Fahmi Ahmad Mandal, Uttam Kumar Chatterjee, Bappaditya Glidant effect of hydrophobic and hydrophilic nanosilica on a cohesivepowder: comparison of different flow characterization techniques
description	The methods used for flow characterization of a powder mass include the angle of repose (AOR), Carrindex (CI), and powder flow tester (PFT). The use of nanosilica as a flow modifier (glidant) is very com-mon in industry. This study aims to compare the glidant effect of hydrophobic and hydrophilic silica ona poorly flowable active pharmaceutical ingredient (ibuprofen) by different flow characterization tech-niques. Different percentages (0.5, 1.0, and 2.0 wt%) of both types of mixed silica–ibuprofen powders wereevaluated by the AOR, CI, bulk density, and PFT. The flow factor, effective angle of friction, and cohesionwere determined to explain the bulk powder properties. The results show that different types of silicashow different levels of flow property improvement, but the techniques do not equally discriminate thedifferences. Hydrophobic silica results in better improvement of the flow property than hydrophilic silica,probably because of its better surface coverage of silica on the host particles. Change of the bulk densitywith applied pressure was significant for the different powders. This study demonstrates that combiningseveral characterization methods provides a better understanding of bulk powder flow properties withrespect to powder–process relationships than a single flow indicator
format	Article
author	Ruzaidi, Fahmi Ahmad Mandal, Uttam Kumar Chatterjee, Bappaditya
author_facet	Ruzaidi, Fahmi Ahmad Mandal, Uttam Kumar Chatterjee, Bappaditya
author_sort	Ruzaidi, Fahmi Ahmad
title	Glidant effect of hydrophobic and hydrophilic nanosilica on a cohesivepowder: comparison of different flow characterization techniques
title_short	Glidant effect of hydrophobic and hydrophilic nanosilica on a cohesivepowder: comparison of different flow characterization techniques
title_full	Glidant effect of hydrophobic and hydrophilic nanosilica on a cohesivepowder: comparison of different flow characterization techniques
title_fullStr	Glidant effect of hydrophobic and hydrophilic nanosilica on a cohesivepowder: comparison of different flow characterization techniques
title_full_unstemmed	Glidant effect of hydrophobic and hydrophilic nanosilica on a cohesivepowder: comparison of different flow characterization techniques
title_sort	glidant effect of hydrophobic and hydrophilic nanosilica on a cohesivepowder: comparison of different flow characterization techniques
publisher	Elsevier
publishDate	2017
url	http://irep.iium.edu.my/51875/ http://irep.iium.edu.my/51875/ http://irep.iium.edu.my/51875/ http://irep.iium.edu.my/51875/25/51875_Glidant%20effect%20of%20hydrophobic.pdf http://irep.iium.edu.my/51875/8/51875_Glidant%20effect%20of%20hydrophobic_SCOPUS.pdf http://irep.iium.edu.my/51875/9/51875_Glidant%20effect%20of%20hydrophobic_WOS.pdf
first_indexed	2023-09-18T21:13:33Z
last_indexed	2023-09-18T21:13:33Z
_version_	1777411411725516800

Glidant effect of hydrophobic and hydrophilic nanosilica on a cohesivepowder: comparison of different flow characterization techniques

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