Analysis of the Cerebrospinal Fluid Flow in the Stenosed Aqueduct of Sylvius

Introduction: A 3D model of the aqueduct of Sylvius, i.e. the region of interest (ROI) in the human ventricular system (HVS) is used to investigate the flow of CSF within the human brain, using Computational Fluid Dynamics (CFD). CSF can be modeled as a Newtonian Fluid and its flow through the ROI...

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Main Authors:	H, Edi Azali, A G, Ahmad Lutfi, S, Amir Hamzah, Osman, Kahar, A K, Mohammed Rafiq, Abd. Aziz, Azian, Sa'at@Yusof, Azlin
Format:	Conference or Workshop Item
Language:	English
Published:	2011
Subjects:	TA164 Bioengineering
Online Access:	http://irep.iium.edu.my/5187/ http://irep.iium.edu.my/5187/1/CSF_Flow_Analysis_for_CoR_2011.pdf

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recordtype	eprints
spelling	iium-51872013-04-27T08:15:12Z http://irep.iium.edu.my/5187/ Analysis of the Cerebrospinal Fluid Flow in the Stenosed Aqueduct of Sylvius H, Edi Azali A G, Ahmad Lutfi S, Amir Hamzah Osman, Kahar A K, Mohammed Rafiq Abd. Aziz, Azian Sa'at@Yusof, Azlin TA164 Bioengineering Introduction: A 3D model of the aqueduct of Sylvius, i.e. the region of interest (ROI) in the human ventricular system (HVS) is used to investigate the flow of CSF within the human brain, using Computational Fluid Dynamics (CFD). CSF can be modeled as a Newtonian Fluid and its flow through the ROI can be visualized using CFD. In this investigation a 3D geometric model of the ROI is constructed from MRI data. The flow of CSF within the ROI is a complicated phenomenon due to the complex ROI geometry. Different flow rate was simulated at the foramen of Monro and a small stenosis was modeled at the middle of the Aqueduct of Sylvius. Understanding the nature of CSF flow may allow engineers and physicians to design medical techniques and drugs to treat various ventricular complications, such as hydrocephalus as a result of obstruction. Objective: To analyze cerebrospinal fluid flow through the region of interest i.e.Aqueduct of Sylvius. Scopes: •With&withoutblockageinAqueductofSylvius. •Numericalstudy(3D-modelling). •Laminar and turbulence model is used. Conclusion: CFD simulations was used to obtain ventricular geometry from anatomical MRI images. In Engineering Fluid Dynamics (EFD), various flow rates was artificially defined at inlets & stenosed aqueduct was modeled within the domain of the geometry. The results show as the flow rate increase, the pressure drop of CSF in the ROI proportionally increased. For normal CSF flow rate, the presence of stenosis in the aqueduct demonstrates a significant increased pressure drop. 2011-04-08 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/5187/1/CSF_Flow_Analysis_for_CoR_2011.pdf H, Edi Azali and A G, Ahmad Lutfi and S, Amir Hamzah and Osman, Kahar and A K, Mohammed Rafiq and Abd. Aziz, Azian and Sa'at@Yusof, Azlin (2011) Analysis of the Cerebrospinal Fluid Flow in the Stenosed Aqueduct of Sylvius. In: Annual Scientific Meeting, College of Radiology, Malaysia, 8 - 10 April 2011, The Legend Hotel, Kuala Lumpur. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	TA164 Bioengineering
spellingShingle	TA164 Bioengineering H, Edi Azali A G, Ahmad Lutfi S, Amir Hamzah Osman, Kahar A K, Mohammed Rafiq Abd. Aziz, Azian Sa'at@Yusof, Azlin Analysis of the Cerebrospinal Fluid Flow in the Stenosed Aqueduct of Sylvius
description	Introduction: A 3D model of the aqueduct of Sylvius, i.e. the region of interest (ROI) in the human ventricular system (HVS) is used to investigate the flow of CSF within the human brain, using Computational Fluid Dynamics (CFD). CSF can be modeled as a Newtonian Fluid and its flow through the ROI can be visualized using CFD. In this investigation a 3D geometric model of the ROI is constructed from MRI data. The flow of CSF within the ROI is a complicated phenomenon due to the complex ROI geometry. Different flow rate was simulated at the foramen of Monro and a small stenosis was modeled at the middle of the Aqueduct of Sylvius. Understanding the nature of CSF flow may allow engineers and physicians to design medical techniques and drugs to treat various ventricular complications, such as hydrocephalus as a result of obstruction. Objective: To analyze cerebrospinal fluid flow through the region of interest i.e.Aqueduct of Sylvius. Scopes: •With&withoutblockageinAqueductofSylvius. •Numericalstudy(3D-modelling). •Laminar and turbulence model is used. Conclusion: CFD simulations was used to obtain ventricular geometry from anatomical MRI images. In Engineering Fluid Dynamics (EFD), various flow rates was artificially defined at inlets & stenosed aqueduct was modeled within the domain of the geometry. The results show as the flow rate increase, the pressure drop of CSF in the ROI proportionally increased. For normal CSF flow rate, the presence of stenosis in the aqueduct demonstrates a significant increased pressure drop.
format	Conference or Workshop Item
author	H, Edi Azali A G, Ahmad Lutfi S, Amir Hamzah Osman, Kahar A K, Mohammed Rafiq Abd. Aziz, Azian Sa'at@Yusof, Azlin
author_facet	H, Edi Azali A G, Ahmad Lutfi S, Amir Hamzah Osman, Kahar A K, Mohammed Rafiq Abd. Aziz, Azian Sa'at@Yusof, Azlin
author_sort	H, Edi Azali
title	Analysis of the Cerebrospinal Fluid Flow in the Stenosed Aqueduct of Sylvius
title_short	Analysis of the Cerebrospinal Fluid Flow in the Stenosed Aqueduct of Sylvius
title_full	Analysis of the Cerebrospinal Fluid Flow in the Stenosed Aqueduct of Sylvius
title_fullStr	Analysis of the Cerebrospinal Fluid Flow in the Stenosed Aqueduct of Sylvius
title_full_unstemmed	Analysis of the Cerebrospinal Fluid Flow in the Stenosed Aqueduct of Sylvius
title_sort	analysis of the cerebrospinal fluid flow in the stenosed aqueduct of sylvius
publishDate	2011
url	http://irep.iium.edu.my/5187/ http://irep.iium.edu.my/5187/1/CSF_Flow_Analysis_for_CoR_2011.pdf
first_indexed	2023-09-18T20:13:40Z
last_indexed	2023-09-18T20:13:40Z
_version_	1777407644326166528

Analysis of the Cerebrospinal Fluid Flow in the Stenosed Aqueduct of Sylvius

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