Anticancer peptides derived from Supermeal worm, Zophobas morio
Cancer is an extremely complicated disease and still presents enormous challenges in the medical world. In recent decades, doctors and researchers were able to find some potential compounds that may be able to treat cancer, but due to the difficulties commercialization poses like mass production,...
| Main Authors: | , , , |
|---|---|
| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
Kulliyah of Engineering, International Islamic University Malaysia
2016
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/51726/ http://irep.iium.edu.my/51726/ http://irep.iium.edu.my/51726/1/51726.pdf |
| Summary: | Cancer is an extremely complicated disease and still presents enormous challenges in the medical world. In
recent decades, doctors and researchers were able to find some potential compounds that may be able to treat
cancer, but due to the difficulties commercialization poses like mass production, high cost of clinical trials
and expensive formulation, not many of these compounds have reached the market. Currently, the search for
anticancer compounds has garner a lot of interest, especially in finding them from the natural sources. In this
study, compounds, supposedly peptides, extracted from cheap, easily maintained Supermeal worm (Zophobas
morio) using two types of acidified organic solvent, ethanol and isopropanol, were shown to inhibit the growth
of MCF-7, a breast cancer cell line. A comparative study of the effects were carried out on Vero cell, a normal
cell line. Results showed that, the two type of extracts inhibits growth of MCF-7 cell at varying degrees, but
on the other hands, have much less effect on Vero cell. Extracts, identified using Raman Spectroscopy shows
peaks at 1349 cm-1
, 944 cm-1
and 841 cm-1
indicating the presence of Tyr, Try and Gly. In addition, UV-vis
analysis showed peaks in the range of 260 to 280 nm, inferring the presence of Tyr and Try, whereas the
highest peak, 3.608 at 230 nm indicates the presence of peptide bond. All the results of analyses implied that
the anticancer compounds contain peptides |
|---|