Weight changes during chemotherapy and prognostic outcome in breast cancer: A preliminary assessment in single centre cohort

A concern in breast cancer involves changes in weight which may adversely affect the prognosis of patients. This study intended to evaluate weight changed uring chemotherapy and its association with prognostic outcome measured as event-free survival (EFS)among breast cancer patients. A total of63 wo...

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Main Authors:	Lua, Pei Lin, Zakaria, Noor Salihah, Mamat, Nik Mazlan
Format:	Article
Language:	English English
Published:	Malaysian Public Health Physicians’ Association 2016
Subjects:	R Medicine (General) RA Public aspects of medicine RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Online Access:	http://irep.iium.edu.my/51566/ http://irep.iium.edu.my/51566/ http://irep.iium.edu.my/51566/1/2016_Mal_J_Public_hlth_Med_Weight_Changes.pdf http://irep.iium.edu.my/51566/4/51566_%20Weight%20changes%20during%20chemotherapy_SCOPUS.pdf

id	iium-51566
recordtype	eprints
spelling	iium-515662017-04-18T04:15:04Z http://irep.iium.edu.my/51566/ Weight changes during chemotherapy and prognostic outcome in breast cancer: A preliminary assessment in single centre cohort Lua, Pei Lin Zakaria, Noor Salihah Mamat, Nik Mazlan R Medicine (General) RA Public aspects of medicine RC0254 Neoplasms. Tumors. Oncology (including Cancer) A concern in breast cancer involves changes in weight which may adversely affect the prognosis of patients. This study intended to evaluate weight changed uring chemotherapy and its association with prognostic outcome measured as event-free survival (EFS)among breast cancer patients. A total of63 women diagnosed with breast cancer and have been treated by anthracycline-based chemotherapy between 2005 and 2011were included.A weight change (WC) was calculated based on relative percentage of weight changes from baseline to post-chemotherapy and categorized into either weight change (WC >5%) or stable (±5% WC).Survival probabilities were estimated using the Kaplan-Meier (SPSS 20). Upon treatment completion, 42.9% of the women experienced weight changes. A small weight reduction was observed (61.1 ± 11.6kg to 60.2 ± 11.9kg; -0.8 ± 4.0kg; p=0.106). The median EFS of women who experienced weight change was shorter (median 61.0 months) compared to those who maintained their weight (median 89.0 months) (p=0.044). In this study, weight changes during breast cancer chemotherapy were associated with poorer prognosis in comparison to women who maintained their weight. Malaysian Public Health Physicians’ Association 2016 Article PeerReviewed application/pdf en http://irep.iium.edu.my/51566/1/2016_Mal_J_Public_hlth_Med_Weight_Changes.pdf application/pdf en http://irep.iium.edu.my/51566/4/51566_%20Weight%20changes%20during%20chemotherapy_SCOPUS.pdf Lua, Pei Lin and Zakaria, Noor Salihah and Mamat, Nik Mazlan (2016) Weight changes during chemotherapy and prognostic outcome in breast cancer: A preliminary assessment in single centre cohort. Malaysian Journal of Public Health Medicine, 16 (1). pp. 129-136. ISSN 1675–0306 http://www.mjphm.org.my/mjphm/index.php?option=com_content&view=category&id=107&Itemid=121
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General) RA Public aspects of medicine RC0254 Neoplasms. Tumors. Oncology (including Cancer)
spellingShingle	R Medicine (General) RA Public aspects of medicine RC0254 Neoplasms. Tumors. Oncology (including Cancer) Lua, Pei Lin Zakaria, Noor Salihah Mamat, Nik Mazlan Weight changes during chemotherapy and prognostic outcome in breast cancer: A preliminary assessment in single centre cohort
description	A concern in breast cancer involves changes in weight which may adversely affect the prognosis of patients. This study intended to evaluate weight changed uring chemotherapy and its association with prognostic outcome measured as event-free survival (EFS)among breast cancer patients. A total of63 women diagnosed with breast cancer and have been treated by anthracycline-based chemotherapy between 2005 and 2011were included.A weight change (WC) was calculated based on relative percentage of weight changes from baseline to post-chemotherapy and categorized into either weight change (WC >5%) or stable (±5% WC).Survival probabilities were estimated using the Kaplan-Meier (SPSS 20). Upon treatment completion, 42.9% of the women experienced weight changes. A small weight reduction was observed (61.1 ± 11.6kg to 60.2 ± 11.9kg; -0.8 ± 4.0kg; p=0.106). The median EFS of women who experienced weight change was shorter (median 61.0 months) compared to those who maintained their weight (median 89.0 months) (p=0.044). In this study, weight changes during breast cancer chemotherapy were associated with poorer prognosis in comparison to women who maintained their weight.
format	Article
author	Lua, Pei Lin Zakaria, Noor Salihah Mamat, Nik Mazlan
author_facet	Lua, Pei Lin Zakaria, Noor Salihah Mamat, Nik Mazlan
author_sort	Lua, Pei Lin
title	Weight changes during chemotherapy and prognostic outcome in breast cancer: A preliminary assessment in single centre cohort
title_short	Weight changes during chemotherapy and prognostic outcome in breast cancer: A preliminary assessment in single centre cohort
title_full	Weight changes during chemotherapy and prognostic outcome in breast cancer: A preliminary assessment in single centre cohort
title_fullStr	Weight changes during chemotherapy and prognostic outcome in breast cancer: A preliminary assessment in single centre cohort
title_full_unstemmed	Weight changes during chemotherapy and prognostic outcome in breast cancer: A preliminary assessment in single centre cohort
title_sort	weight changes during chemotherapy and prognostic outcome in breast cancer: a preliminary assessment in single centre cohort
publisher	Malaysian Public Health Physicians’ Association
publishDate	2016
url	http://irep.iium.edu.my/51566/ http://irep.iium.edu.my/51566/ http://irep.iium.edu.my/51566/1/2016_Mal_J_Public_hlth_Med_Weight_Changes.pdf http://irep.iium.edu.my/51566/4/51566_%20Weight%20changes%20during%20chemotherapy_SCOPUS.pdf
first_indexed	2023-09-18T21:13:00Z
last_indexed	2023-09-18T21:13:00Z
_version_	1777411377806180352

Weight changes during chemotherapy and prognostic outcome in breast cancer: A preliminary assessment in single centre cohort

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