Soy intake and breast cancer risk: a meta-analysis of epidemiological studies

The impact of soy intake on breast cancer risk has been investigated extensively. However, these studies reported conflicting results. The objective of this study is to perform comprehensive review and updated meta-analysis on the association between soy intake and breast cancer risk and to identify...

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Main Authors:	Bahrom, Suhaila, Nik Idris, Nik Ruzni
Format:	Conference or Workshop Item
Language:	English English
Published:	AIP Publishing 2016
Subjects:	RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Online Access:	http://irep.iium.edu.my/51385/ http://irep.iium.edu.my/51385/ http://irep.iium.edu.my/51385/ http://irep.iium.edu.my/51385/1/51385_Soy%20Intake%20and%20Breast%20Cancer.pdf http://irep.iium.edu.my/51385/2/51385_Soy%20Intake%20and%20Breast%20Cancer_SCOPUS.pdf

id	iium-51385
recordtype	eprints
spelling	iium-513852017-06-05T06:16:09Z http://irep.iium.edu.my/51385/ Soy intake and breast cancer risk: a meta-analysis of epidemiological studies Bahrom, Suhaila Nik Idris, Nik Ruzni RC0254 Neoplasms. Tumors. Oncology (including Cancer) The impact of soy intake on breast cancer risk has been investigated extensively. However, these studies reported conflicting results. The objective of this study is to perform comprehensive review and updated meta-analysis on the association between soy intake and breast cancer risk and to identify significant factors which may contribute to the inconsistencies of results of the individual studies. Based on reviews of existing meta-analysis, we identified four main factors which contributed to the inconsistencies of results of individual studies on the association of soy intake and breast cancer risk namely; region, menopausal status of the patients, soy type and study design. Accordingly, we performed an updated meta-analysis of 57 studies grouped by the identified factors. Pooled ORs of studies carried out in Asian countries suggested that soy isoflavones consumption was inversely associated with the risk of breast cancer among both pre and postmenopausal women (OR=0.63, 95% CI: 0.54-0.74 for premenopausal women; OR=0.63, 95% CI: 0.52-0.75 for postmenopausal women). However, pooled OR of studies carried out in Western countries shows that there is no statistically significant association between soy intake and breast cancer risk (OR=0.98, 95% CI: 0.93-1.03). Our study suggests that soy food intake is associated with significantly reduced risk of breast cancer for women in Asian but not in Western countries. Further epidemiological studies need to be conducted with more comprehensive information about the dietary intake and relative exposure among the women in these two different regions. AIP Publishing 2016 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/51385/1/51385_Soy%20Intake%20and%20Breast%20Cancer.pdf application/pdf en http://irep.iium.edu.my/51385/2/51385_Soy%20Intake%20and%20Breast%20Cancer_SCOPUS.pdf Bahrom, Suhaila and Nik Idris, Nik Ruzni (2016) Soy intake and breast cancer risk: a meta-analysis of epidemiological studies. In: 2nd International Conference on Mathematical Sciences and Statistics 2016 (ICMSS2016), 26-28 January 2016, Kuala Lumpur, Malaysia. http://scitation.aip.org/content/aip/proceeding/aipcp/10.1063/1.4952555 10.1063/1.4952555
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RC0254 Neoplasms. Tumors. Oncology (including Cancer)
spellingShingle	RC0254 Neoplasms. Tumors. Oncology (including Cancer) Bahrom, Suhaila Nik Idris, Nik Ruzni Soy intake and breast cancer risk: a meta-analysis of epidemiological studies
description	The impact of soy intake on breast cancer risk has been investigated extensively. However, these studies reported conflicting results. The objective of this study is to perform comprehensive review and updated meta-analysis on the association between soy intake and breast cancer risk and to identify significant factors which may contribute to the inconsistencies of results of the individual studies. Based on reviews of existing meta-analysis, we identified four main factors which contributed to the inconsistencies of results of individual studies on the association of soy intake and breast cancer risk namely; region, menopausal status of the patients, soy type and study design. Accordingly, we performed an updated meta-analysis of 57 studies grouped by the identified factors. Pooled ORs of studies carried out in Asian countries suggested that soy isoflavones consumption was inversely associated with the risk of breast cancer among both pre and postmenopausal women (OR=0.63, 95% CI: 0.54-0.74 for premenopausal women; OR=0.63, 95% CI: 0.52-0.75 for postmenopausal women). However, pooled OR of studies carried out in Western countries shows that there is no statistically significant association between soy intake and breast cancer risk (OR=0.98, 95% CI: 0.93-1.03). Our study suggests that soy food intake is associated with significantly reduced risk of breast cancer for women in Asian but not in Western countries. Further epidemiological studies need to be conducted with more comprehensive information about the dietary intake and relative exposure among the women in these two different regions.
format	Conference or Workshop Item
author	Bahrom, Suhaila Nik Idris, Nik Ruzni
author_facet	Bahrom, Suhaila Nik Idris, Nik Ruzni
author_sort	Bahrom, Suhaila
title	Soy intake and breast cancer risk: a meta-analysis of epidemiological studies
title_short	Soy intake and breast cancer risk: a meta-analysis of epidemiological studies
title_full	Soy intake and breast cancer risk: a meta-analysis of epidemiological studies
title_fullStr	Soy intake and breast cancer risk: a meta-analysis of epidemiological studies
title_full_unstemmed	Soy intake and breast cancer risk: a meta-analysis of epidemiological studies
title_sort	soy intake and breast cancer risk: a meta-analysis of epidemiological studies
publisher	AIP Publishing
publishDate	2016
url	http://irep.iium.edu.my/51385/ http://irep.iium.edu.my/51385/ http://irep.iium.edu.my/51385/ http://irep.iium.edu.my/51385/1/51385_Soy%20Intake%20and%20Breast%20Cancer.pdf http://irep.iium.edu.my/51385/2/51385_Soy%20Intake%20and%20Breast%20Cancer_SCOPUS.pdf
first_indexed	2023-09-18T21:12:44Z
last_indexed	2023-09-18T21:12:44Z
_version_	1777411361078247424

Soy intake and breast cancer risk: a meta-analysis of epidemiological studies

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