Fabrication of Fucoxanthin-Loaded Microsphere ( F-LM) by two steps double-emulsion solvent evaporation methods and characterization of fucoxanthin before and after microencapsulation

Microencapsulation is a promising approach in drug delivery to protect the drug from degradation and allow controlled release of the drug in the body. Fucoxanthin-loaded microsphere (F-LM) was fabricated by two step w/o/w double emulsion solvent evaporation method with poly (L-lactic-co-glycolic aci...

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Main Authors:	Noviendri, Dedi, Jaswir, Irwandi, Bakhtiar, M. Taher, Mohamed, Farahidah, Mohd. Salleh, Hamzah, Noorbatcha, Ibrahim Ali, Octavianti, Fitri, Lestari, Widya, Hendri, Ridar, Ahmad, Hasna, Miyashita, Kazuo, Abdullah, Alias
Format:	Article
Language:	English English English
Published:	Japan Oil Chemists' Society 2016
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/51371/ http://irep.iium.edu.my/51371/ http://irep.iium.edu.my/51371/ http://irep.iium.edu.my/51371/4/51371.pdf http://irep.iium.edu.my/51371/7/51371_Fabrication%20of%20fucoxanthin-loaded%20microsphere_Scopus.pdf http://irep.iium.edu.my/51371/8/51371_Fabrication%20of%20fucoxanthin-loaded%20microsphere_WoS.pdf

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spelling	iium-513712017-04-19T07:58:57Z http://irep.iium.edu.my/51371/ Fabrication of Fucoxanthin-Loaded Microsphere ( F-LM) by two steps double-emulsion solvent evaporation methods and characterization of fucoxanthin before and after microencapsulation Noviendri, Dedi Jaswir, Irwandi Bakhtiar, M. Taher Mohamed, Farahidah Mohd. Salleh, Hamzah Noorbatcha, Ibrahim Ali Octavianti, Fitri Lestari, Widya Hendri, Ridar Ahmad, Hasna Miyashita, Kazuo Abdullah, Alias RS Pharmacy and materia medica Microencapsulation is a promising approach in drug delivery to protect the drug from degradation and allow controlled release of the drug in the body. Fucoxanthin-loaded microsphere (F-LM) was fabricated by two step w/o/w double emulsion solvent evaporation method with poly (L-lactic-co-glycolic acid) (PLGA) as carrier. The effect of four types of surfactants (PVA, Tween-20, Span-20 and SDS), homogenization speed, and concentration of PLGA polymer and surfactant (PVA), respectively, on particle size and morphology of F-LM were investigated. Among the surfactants tested, PVA showed the best results with smallest particle size (9.18 µm) and a smooth spherical surface. Increasing the homogenization speed resulted in a smaller mean F-LM particle size [d(0.50)] from 17.12 to 9.18 µm. Best particle size results and good morphology were attained at homogenization speed of 20 500 rpm. Meanwhile, increased PLGA concentration from 1.5 to 11.0 (% w/v) resulted in increased F-LM particle size. The mean particle size [d(0.5)] of F-LM increased from 3.93 to 11.88 µm. At 6.0 (% w/v) PLGA, F-LM showed the best structure and external morphology. Finally, increasing PVA concentration from 0.5 to 3.5 (% w/v) resulted in decreased particle size from 9.18 to 4.86 µm. Fucoxanthin characterization before and after microencapsulation was carried out to assess the success of the microencapsulation procedure. Thermo gravimetry analysis (TGA), glass transition (Tg) temperature of F-LM and fucoxanthin measured using DSC, ATR-FTIR and XRD indicated that fucoxanthin was successfully encapsulated into the PLGA matrix, while maintaining the structural and chemical integrity of fucoxanthin. Japan Oil Chemists' Society 2016 Article PeerReviewed application/pdf en http://irep.iium.edu.my/51371/4/51371.pdf application/pdf en http://irep.iium.edu.my/51371/7/51371_Fabrication%20of%20fucoxanthin-loaded%20microsphere_Scopus.pdf application/pdf en http://irep.iium.edu.my/51371/8/51371_Fabrication%20of%20fucoxanthin-loaded%20microsphere_WoS.pdf Noviendri, Dedi and Jaswir, Irwandi and Bakhtiar, M. Taher and Mohamed, Farahidah and Mohd. Salleh, Hamzah and Noorbatcha, Ibrahim Ali and Octavianti, Fitri and Lestari, Widya and Hendri, Ridar and Ahmad, Hasna and Miyashita, Kazuo and Abdullah, Alias (2016) Fabrication of Fucoxanthin-Loaded Microsphere ( F-LM) by two steps double-emulsion solvent evaporation methods and characterization of fucoxanthin before and after microencapsulation. Journal of Oleo Science, 65 (8). pp. 641-653. ISSN 1347-3352 E-ISSN 1345-8957 https://www.jstage.jst.go.jp/article/jos/65/8/65_ess16018/_pdf 10.5650/jos.ess 16018
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Noviendri, Dedi Jaswir, Irwandi Bakhtiar, M. Taher Mohamed, Farahidah Mohd. Salleh, Hamzah Noorbatcha, Ibrahim Ali Octavianti, Fitri Lestari, Widya Hendri, Ridar Ahmad, Hasna Miyashita, Kazuo Abdullah, Alias Fabrication of Fucoxanthin-Loaded Microsphere ( F-LM) by two steps double-emulsion solvent evaporation methods and characterization of fucoxanthin before and after microencapsulation
description	Microencapsulation is a promising approach in drug delivery to protect the drug from degradation and allow controlled release of the drug in the body. Fucoxanthin-loaded microsphere (F-LM) was fabricated by two step w/o/w double emulsion solvent evaporation method with poly (L-lactic-co-glycolic acid) (PLGA) as carrier. The effect of four types of surfactants (PVA, Tween-20, Span-20 and SDS), homogenization speed, and concentration of PLGA polymer and surfactant (PVA), respectively, on particle size and morphology of F-LM were investigated. Among the surfactants tested, PVA showed the best results with smallest particle size (9.18 µm) and a smooth spherical surface. Increasing the homogenization speed resulted in a smaller mean F-LM particle size [d(0.50)] from 17.12 to 9.18 µm. Best particle size results and good morphology were attained at homogenization speed of 20 500 rpm. Meanwhile, increased PLGA concentration from 1.5 to 11.0 (% w/v) resulted in increased F-LM particle size. The mean particle size [d(0.5)] of F-LM increased from 3.93 to 11.88 µm. At 6.0 (% w/v) PLGA, F-LM showed the best structure and external morphology. Finally, increasing PVA concentration from 0.5 to 3.5 (% w/v) resulted in decreased particle size from 9.18 to 4.86 µm. Fucoxanthin characterization before and after microencapsulation was carried out to assess the success of the microencapsulation procedure. Thermo gravimetry analysis (TGA), glass transition (Tg) temperature of F-LM and fucoxanthin measured using DSC, ATR-FTIR and XRD indicated that fucoxanthin was successfully encapsulated into the PLGA matrix, while maintaining the structural and chemical integrity of fucoxanthin.
format	Article
author	Noviendri, Dedi Jaswir, Irwandi Bakhtiar, M. Taher Mohamed, Farahidah Mohd. Salleh, Hamzah Noorbatcha, Ibrahim Ali Octavianti, Fitri Lestari, Widya Hendri, Ridar Ahmad, Hasna Miyashita, Kazuo Abdullah, Alias
author_facet	Noviendri, Dedi Jaswir, Irwandi Bakhtiar, M. Taher Mohamed, Farahidah Mohd. Salleh, Hamzah Noorbatcha, Ibrahim Ali Octavianti, Fitri Lestari, Widya Hendri, Ridar Ahmad, Hasna Miyashita, Kazuo Abdullah, Alias
author_sort	Noviendri, Dedi
title	Fabrication of Fucoxanthin-Loaded Microsphere ( F-LM) by two steps double-emulsion solvent evaporation methods and characterization of fucoxanthin before and after microencapsulation
title_short	Fabrication of Fucoxanthin-Loaded Microsphere ( F-LM) by two steps double-emulsion solvent evaporation methods and characterization of fucoxanthin before and after microencapsulation
title_full	Fabrication of Fucoxanthin-Loaded Microsphere ( F-LM) by two steps double-emulsion solvent evaporation methods and characterization of fucoxanthin before and after microencapsulation
title_fullStr	Fabrication of Fucoxanthin-Loaded Microsphere ( F-LM) by two steps double-emulsion solvent evaporation methods and characterization of fucoxanthin before and after microencapsulation
title_full_unstemmed	Fabrication of Fucoxanthin-Loaded Microsphere ( F-LM) by two steps double-emulsion solvent evaporation methods and characterization of fucoxanthin before and after microencapsulation
title_sort	fabrication of fucoxanthin-loaded microsphere ( f-lm) by two steps double-emulsion solvent evaporation methods and characterization of fucoxanthin before and after microencapsulation
publisher	Japan Oil Chemists' Society
publishDate	2016
url	http://irep.iium.edu.my/51371/ http://irep.iium.edu.my/51371/ http://irep.iium.edu.my/51371/ http://irep.iium.edu.my/51371/4/51371.pdf http://irep.iium.edu.my/51371/7/51371_Fabrication%20of%20fucoxanthin-loaded%20microsphere_Scopus.pdf http://irep.iium.edu.my/51371/8/51371_Fabrication%20of%20fucoxanthin-loaded%20microsphere_WoS.pdf
first_indexed	2023-09-18T21:12:43Z
last_indexed	2023-09-18T21:12:43Z
_version_	1777411359765430272

Fabrication of Fucoxanthin-Loaded Microsphere ( F-LM) by two steps double-emulsion solvent evaporation methods and characterization of fucoxanthin before and after microencapsulation

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