Incrassamarin A–D: Four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities
Four new 4-substituted coumarins, incrassamarin A (1), B (2), C (3) and D (4) with (7S,8S)-7,8-dihydro-5- hydroxy-7,8-dimethyl-4-propyl-2H,6H-benzo[1,2-b;5,4-b’]dipyran-2,6-dione (5), friedelin, carpachromene, amentoflavone, epiafzelechin and L-quercitrin were isolated from the barks and leaves of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Elsevier
2016
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/50956/ http://irep.iium.edu.my/50956/ http://irep.iium.edu.my/50956/ http://irep.iium.edu.my/50956/2/Incrassamarin_A%E2%80%93D_Four_new_4-substituted_coumarins__from.pdf http://irep.iium.edu.my/50956/7/50956_Incrassamarin%20A%E2%80%93D_WoS.pdf |
| Summary: | Four new 4-substituted coumarins, incrassamarin A (1), B (2), C (3) and D (4) with (7S,8S)-7,8-dihydro-5-
hydroxy-7,8-dimethyl-4-propyl-2H,6H-benzo[1,2-b;5,4-b’]dipyran-2,6-dione (5), friedelin, carpachromene,
amentoflavone, epiafzelechin and L-quercitrin were isolated from the barks and leaves of Calophyllum incrassatum (Guttiferae). The compounds were isolated and purified by size-exclusion recycling HPLC and column chromatographic techniques. The structures of the compounds were determined by spectroscopic means. The compounds were tested for their cytotoxic activity towards MCF-7 and A-549 cell lines and a-glucosidase enzymatic inhibitory activity. Compound (1) displayed cytotoxic activity against A-549 cell lines with IC50 87.71mg/mL and showed inhibition towards a-glucosidase enzymatic activity with IC50 93.25mM. This is the first report on the isolation of phytochemicals from the barks and leaves of C. incrassatum and their bioactivities. |
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