Nephrotoxicity in chronic low dose organophosphate exposure
Objectives: People are exposed to chronic low dose organophosphates (OPs) pesticides through agriculture and pest control activities. Apparently, there were significant epidemiological reports suggesting pesticides role in chronic kidney disease. This observation is yet to be confirmed with appropr...
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2016
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| Online Access: | http://irep.iium.edu.my/50925/ http://irep.iium.edu.my/50925/ http://irep.iium.edu.my/50925/4/cpathasm2016.pptx_table.pdf http://irep.iium.edu.my/50925/12/Putrajaya_conference_2016.pdf |
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iium-50925 |
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eprints |
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iium-509252017-03-06T02:18:34Z http://irep.iium.edu.my/50925/ Nephrotoxicity in chronic low dose organophosphate exposure Aung, Sanda Abdullah, Nor Zamzila A.Talib, Norlelawati Mohd Noor, Noriah Harun, Norra Zainone, Zamzuria Mat Abdul Razak, Tariq RB Pathology Objectives: People are exposed to chronic low dose organophosphates (OPs) pesticides through agriculture and pest control activities. Apparently, there were significant epidemiological reports suggesting pesticides role in chronic kidney disease. This observation is yet to be confirmed with appropriate experimental model of chronic OPs exposure on animals. Thus, the aim of this study is to observe for histomorphological characteristics related to nephropathy in the kidneys of rats upon exposure to chronic low dose OPs. Materials and Methods: 24 males Sprague-Dawley rats were randomly divided into 3 groups of 6 rats each with Group 1 as a Control group, whilst Group 2 and Group 3 received subcutaneous vehicle (3% dimethyl sulphoxide + 97% v/v soy oil) and 18.0 mg/kg BW chlorpyrifos respectively, every other day for 180 days. After treatment, the rats were sacrificed and the right kidney was subjected to routine H&E examination and specific Masson-Trichrome and periodic-acid Schiff stain. Results: OPs exposed group (Group 3) exhibited significant histo-morphological abnormalities suggesting cell injury, apoptosis and degenerative changes in glomeruli and tubules. In contrast, the control groups 1 and 2 (vehicle) are spared. Conclusion: Chronic low dose OPs exposure induced nephrotoxicity. The exact mechanism of nephrotoxicity should be further investigated. Keywords: 2016-06-03 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/50925/4/cpathasm2016.pptx_table.pdf application/pdf en http://irep.iium.edu.my/50925/12/Putrajaya_conference_2016.pdf Aung, Sanda and Abdullah, Nor Zamzila and A.Talib, Norlelawati and Mohd Noor, Noriah and Harun, Norra and Zainone, Zamzuria Mat and Abdul Razak, Tariq (2016) Nephrotoxicity in chronic low dose organophosphate exposure. In: 2016 Annual Scientific Meeting, Colleage of Pathologists, Academy of Medicine of Malaysia updates and Dilemmas in Pathology, 3-5 Jun 2016, Putrajaya. (Unpublished) https://cpathasm2016.wordpress.com/abstracts-2/ |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
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IIUM Repository |
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Online Access |
| language |
English English |
| topic |
RB Pathology |
| spellingShingle |
RB Pathology Aung, Sanda Abdullah, Nor Zamzila A.Talib, Norlelawati Mohd Noor, Noriah Harun, Norra Zainone, Zamzuria Mat Abdul Razak, Tariq Nephrotoxicity in chronic low dose organophosphate exposure |
| description |
Objectives: People are exposed to chronic low dose organophosphates (OPs) pesticides through agriculture and pest control activities. Apparently, there were significant epidemiological reports suggesting pesticides role in chronic kidney disease. This observation is yet to be confirmed with appropriate experimental model of chronic OPs exposure on animals. Thus, the aim of this study is to observe for histomorphological characteristics related to nephropathy in the kidneys of rats upon exposure to chronic low dose OPs. Materials and Methods: 24 males Sprague-Dawley rats were randomly divided into 3 groups of 6 rats each with Group 1 as a Control group, whilst Group 2 and Group 3 received subcutaneous vehicle (3% dimethyl sulphoxide + 97% v/v soy oil) and 18.0 mg/kg BW chlorpyrifos respectively, every other day for 180 days. After treatment, the rats were sacrificed and the right kidney was subjected to routine H&E examination and specific Masson-Trichrome and periodic-acid Schiff stain. Results: OPs exposed group (Group 3) exhibited significant histo-morphological abnormalities suggesting cell injury, apoptosis and degenerative changes in glomeruli and tubules. In contrast, the control groups 1 and 2 (vehicle) are spared. Conclusion: Chronic low dose OPs exposure induced nephrotoxicity. The exact mechanism of nephrotoxicity should be further investigated.
Keywords:
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| format |
Conference or Workshop Item |
| author |
Aung, Sanda Abdullah, Nor Zamzila A.Talib, Norlelawati Mohd Noor, Noriah Harun, Norra Zainone, Zamzuria Mat Abdul Razak, Tariq |
| author_facet |
Aung, Sanda Abdullah, Nor Zamzila A.Talib, Norlelawati Mohd Noor, Noriah Harun, Norra Zainone, Zamzuria Mat Abdul Razak, Tariq |
| author_sort |
Aung, Sanda |
| title |
Nephrotoxicity in chronic low dose organophosphate exposure |
| title_short |
Nephrotoxicity in chronic low dose organophosphate exposure |
| title_full |
Nephrotoxicity in chronic low dose organophosphate exposure |
| title_fullStr |
Nephrotoxicity in chronic low dose organophosphate exposure |
| title_full_unstemmed |
Nephrotoxicity in chronic low dose organophosphate exposure |
| title_sort |
nephrotoxicity in chronic low dose organophosphate exposure |
| publishDate |
2016 |
| url |
http://irep.iium.edu.my/50925/ http://irep.iium.edu.my/50925/ http://irep.iium.edu.my/50925/4/cpathasm2016.pptx_table.pdf http://irep.iium.edu.my/50925/12/Putrajaya_conference_2016.pdf |
| first_indexed |
2023-09-18T21:12:04Z |
| last_indexed |
2023-09-18T21:12:04Z |
| _version_ |
1777411318900326400 |