Health professionals' knowledge, attitudes and practices about pharmacovigilance in India: a systematic review and meta-analysis Analysis
Background Spontaneous or voluntary reporting of suspected adverse drug reactions (ADRs) is one of the vital roles of all health professionals. In India, under-reporting of ADRs by health professionals is recognized as one of the leading causes of poor ADR signal detection. Therefore, reviewing...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English English English |
| Published: |
The Public Library of Science (PLoS)
2016
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/50789/ http://irep.iium.edu.my/50789/ http://irep.iium.edu.my/50789/ http://irep.iium.edu.my/50789/4/50789_Health%20professionals%27%20knowledge%2C%20attitudes%20and%20practices%20_Scopus.pdf http://irep.iium.edu.my/50789/5/50789_Health%20professionals%27%20knowledge%2C%20attitudes%20and%20practices%20_WoS.pdf http://irep.iium.edu.my/50789/12/50789_Health%20professionals%27%20knowledge%2C%20attitudes%20and%20practices.pdf |
| Summary: | Background
Spontaneous or voluntary reporting of suspected adverse drug reactions (ADRs) is one of
the vital roles of all health professionals. In India, under-reporting of ADRs by health professionals
is recognized as one of the leading causes of poor ADR signal detection. Therefore,
reviewing the literature can provide a better understanding of the status of knowledge, attitude
and practice (KAP) of Pharmacovigilance (PV) activities by health professionals.
Methods
A systematic review was performed through Pubmed, Scopus, Embase and Google Scholar
scientific databases. Studies pertaining to KAP of PV and ADR reporting by Indian health
professionals between January 2011 and July 2015 were included in a meta-analysis.
Results
A total of 28 studies were included in the systematic review and 18 of them were selected for
meta-analysis. Overall, 55.6%(95%CI 44.4–66.9; p<0.001) of the population studied were
not aware of the existence of the Pharmacovigilance Programme in India (PvPI), and 31.9%
(95%CI 16.3–47.4; p<0.001) thought that "all drugs available in the market are safe". Furthermore,
28.7% (95%CI 16.4–40.9; p<0.001) of them were not interested in reporting
ADRs and 74.5%, (95%CI 67.9–81.9; p<0.001) never reported any ADR to PV centers.
Conclusion
There was an enormous gap of KAP towards PV and ADR reporting, particularly PV practice
in India. There is therefore an urgent need for educational awareness, simplification of the ADR reporting process, and implementation of imperative measures to practice PV
among healthcare professionals. In order to understand the PV status, PvPI should procedurally
assess the KAP of health professionals PV activities in India. |
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