Safety assessment of a new developed fruit juice product - mixed fruit Juice in experimental rats

The interest in dietary antioxidants which are mainly found in fruits, has prompted research in the field of commercial high antioxidant juice for healthy purposes. Fruits also are rich with antioxidants that help in reducing of degenerative diseases such as cancer, arthritis, cardiovascular disease...

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Main Authors:	Hassan, Hadijah, Hazali, Norazlanshah, Ibrahim, Muhammad, Suri, Roowi
Format:	Article
Language:	English English
Published:	Faculty of Food Science and Technology, Universiti Putra Malaysia 2015
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/50774/ http://irep.iium.edu.my/50774/ http://irep.iium.edu.my/50774/1/50774_Safety_assessment_of_a_new_developed_fruit_juice_product_-_mixed_fruit_Juice.pdf http://irep.iium.edu.my/50774/4/50774_Safety_assessment_of_a_new_developed_fruit_juice_product_SCOPUS.pdf

id	iium-50774
recordtype	eprints
spelling	iium-507742017-02-07T04:31:11Z http://irep.iium.edu.my/50774/ Safety assessment of a new developed fruit juice product - mixed fruit Juice in experimental rats Hassan, Hadijah Hazali, Norazlanshah Ibrahim, Muhammad Suri, Roowi Q Science (General) The interest in dietary antioxidants which are mainly found in fruits, has prompted research in the field of commercial high antioxidant juice for healthy purposes. Fruits also are rich with antioxidants that help in reducing of degenerative diseases such as cancer, arthritis, cardiovascular disease and inflammation. Based on the health claims from the natural antioxidants, a new healthy juice called Mixed Fruit Juice (MFJ) has been developed by using three combinations of local fruits (soursop, mango and kasturi lime). In order to promote the commercial use of this product, the safety evaluation is needed to be carried out. The 28-days repeated toxicity test has been conducted in female and male rats for pre-clinical safety assessment prior to human study. There was no mortality observed when varying doses of the MFJ (5, 10 and 20%) administered to all rats. Hematological analysis showed no significant differences in most parameters examined. There were no significant changes observed in the liver and kidney functions tests of all treated-rats as compared to control normal rats. Furthermore, lipid profiles and blood glucose level were also within the normal range as noted in control rats. The present data demonstrate that the supplementation of MFJ did not produce adverse effects on the body system of experimental rats. This is the first documented report on the safety assessment of MFJ in rats. Faculty of Food Science and Technology, Universiti Putra Malaysia 2015-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/50774/1/50774_Safety_assessment_of_a_new_developed_fruit_juice_product_-_mixed_fruit_Juice.pdf application/pdf en http://irep.iium.edu.my/50774/4/50774_Safety_assessment_of_a_new_developed_fruit_juice_product_SCOPUS.pdf Hassan, Hadijah and Hazali, Norazlanshah and Ibrahim, Muhammad and Suri, Roowi (2015) Safety assessment of a new developed fruit juice product - mixed fruit Juice in experimental rats. International Food Research Journal, 22 (6). pp. 2658-2663. ISSN 1985-4668 E-ISSN 2231-7546 http://www.ifrj.upm.edu.my/22%20(06)%202015/(55).pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	Q Science (General)
spellingShingle	Q Science (General) Hassan, Hadijah Hazali, Norazlanshah Ibrahim, Muhammad Suri, Roowi Safety assessment of a new developed fruit juice product - mixed fruit Juice in experimental rats
description	The interest in dietary antioxidants which are mainly found in fruits, has prompted research in the field of commercial high antioxidant juice for healthy purposes. Fruits also are rich with antioxidants that help in reducing of degenerative diseases such as cancer, arthritis, cardiovascular disease and inflammation. Based on the health claims from the natural antioxidants, a new healthy juice called Mixed Fruit Juice (MFJ) has been developed by using three combinations of local fruits (soursop, mango and kasturi lime). In order to promote the commercial use of this product, the safety evaluation is needed to be carried out. The 28-days repeated toxicity test has been conducted in female and male rats for pre-clinical safety assessment prior to human study. There was no mortality observed when varying doses of the MFJ (5, 10 and 20%) administered to all rats. Hematological analysis showed no significant differences in most parameters examined. There were no significant changes observed in the liver and kidney functions tests of all treated-rats as compared to control normal rats. Furthermore, lipid profiles and blood glucose level were also within the normal range as noted in control rats. The present data demonstrate that the supplementation of MFJ did not produce adverse effects on the body system of experimental rats. This is the first documented report on the safety assessment of MFJ in rats.
format	Article
author	Hassan, Hadijah Hazali, Norazlanshah Ibrahim, Muhammad Suri, Roowi
author_facet	Hassan, Hadijah Hazali, Norazlanshah Ibrahim, Muhammad Suri, Roowi
author_sort	Hassan, Hadijah
title	Safety assessment of a new developed fruit juice product - mixed fruit Juice in experimental rats
title_short	Safety assessment of a new developed fruit juice product - mixed fruit Juice in experimental rats
title_full	Safety assessment of a new developed fruit juice product - mixed fruit Juice in experimental rats
title_fullStr	Safety assessment of a new developed fruit juice product - mixed fruit Juice in experimental rats
title_full_unstemmed	Safety assessment of a new developed fruit juice product - mixed fruit Juice in experimental rats
title_sort	safety assessment of a new developed fruit juice product - mixed fruit juice in experimental rats
publisher	Faculty of Food Science and Technology, Universiti Putra Malaysia
publishDate	2015
url	http://irep.iium.edu.my/50774/ http://irep.iium.edu.my/50774/ http://irep.iium.edu.my/50774/1/50774_Safety_assessment_of_a_new_developed_fruit_juice_product_-_mixed_fruit_Juice.pdf http://irep.iium.edu.my/50774/4/50774_Safety_assessment_of_a_new_developed_fruit_juice_product_SCOPUS.pdf
first_indexed	2023-09-18T21:11:50Z
last_indexed	2023-09-18T21:11:50Z
_version_	1777411303886815232

Safety assessment of a new developed fruit juice product - mixed fruit Juice in experimental rats

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