Chemical constituents from stem bark of Garcinia prainiana and their bioactivities

Phytochemical investigations on the hexane and methanol extracts of the dried stem barks of Garcinia prainiana resulted in the isolation of two triterpenes; 3β-hydroxyeupha-5,22-diene (1), 3β-acetoxyeupha-5,22-diene (2) as well as five flavonoids, morelloflavone (3), O-methylfukugetin (4), volkensif...

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Main Authors:	On, Shamsul, Aminudin, Nurul Iman, Ahmad, Farediah, Mohd Sirat, Hasnah, Bakhtiar, M. Taher
Format:	Article
Language:	English English
Published:	International Journal of Pharmacognosy and Phytochemical Resear 2016
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/50725/ http://irep.iium.edu.my/50725/ http://irep.iium.edu.my/50725/1/IJPPR%2CVol8%2CIssue5%2CArticle9.pdf http://irep.iium.edu.my/50725/4/50725_Chemical%20constituents_scopus.pdf

id	iium-50725
recordtype	eprints
spelling	iium-507252017-04-05T02:13:53Z http://irep.iium.edu.my/50725/ Chemical constituents from stem bark of Garcinia prainiana and their bioactivities On, Shamsul Aminudin, Nurul Iman Ahmad, Farediah Mohd Sirat, Hasnah Bakhtiar, M. Taher RS Pharmacy and materia medica Phytochemical investigations on the hexane and methanol extracts of the dried stem barks of Garcinia prainiana resulted in the isolation of two triterpenes; 3β-hydroxyeupha-5,22-diene (1), 3β-acetoxyeupha-5,22-diene (2) as well as five flavonoids, morelloflavone (3), O-methylfukugetin (4), volkensiflavone (5), amentoflavone (6) and 4′′′- methoxyamentoflavone (7). Except for (3) and (5), the rest of the isolated compounds are reported here for the first time from this plant. The structures were established based on spectral analyses. The crudes and compounds were screened for DPPH radical scavenging assay and tyrosinase inhibition activity. The methanol extract and compound (3) were found to show high radical scavenging activity with IC50 15.1 and 15.7 g/mL, respectively. As for tyrosinase inhibition assay, compound (3) was found to exhibit the highest activity with IC50 34.0 mcg/mL International Journal of Pharmacognosy and Phytochemical Resear 2016-05-05 Article PeerReviewed application/pdf en http://irep.iium.edu.my/50725/1/IJPPR%2CVol8%2CIssue5%2CArticle9.pdf application/pdf en http://irep.iium.edu.my/50725/4/50725_Chemical%20constituents_scopus.pdf On, Shamsul and Aminudin, Nurul Iman and Ahmad, Farediah and Mohd Sirat, Hasnah and Bakhtiar, M. Taher (2016) Chemical constituents from stem bark of Garcinia prainiana and their bioactivities. International Journal of Pharmacognosy and Phytochemical Research, 8 (5). pp. 756-760. ISSN 0975-4873 http://impactfactor.org/PDF/IJPPR/8/IJPPR,Vol8,Issue5,Article9.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica On, Shamsul Aminudin, Nurul Iman Ahmad, Farediah Mohd Sirat, Hasnah Bakhtiar, M. Taher Chemical constituents from stem bark of Garcinia prainiana and their bioactivities
description	Phytochemical investigations on the hexane and methanol extracts of the dried stem barks of Garcinia prainiana resulted in the isolation of two triterpenes; 3β-hydroxyeupha-5,22-diene (1), 3β-acetoxyeupha-5,22-diene (2) as well as five flavonoids, morelloflavone (3), O-methylfukugetin (4), volkensiflavone (5), amentoflavone (6) and 4′′′- methoxyamentoflavone (7). Except for (3) and (5), the rest of the isolated compounds are reported here for the first time from this plant. The structures were established based on spectral analyses. The crudes and compounds were screened for DPPH radical scavenging assay and tyrosinase inhibition activity. The methanol extract and compound (3) were found to show high radical scavenging activity with IC50 15.1 and 15.7 g/mL, respectively. As for tyrosinase inhibition assay, compound (3) was found to exhibit the highest activity with IC50 34.0 mcg/mL
format	Article
author	On, Shamsul Aminudin, Nurul Iman Ahmad, Farediah Mohd Sirat, Hasnah Bakhtiar, M. Taher
author_facet	On, Shamsul Aminudin, Nurul Iman Ahmad, Farediah Mohd Sirat, Hasnah Bakhtiar, M. Taher
author_sort	On, Shamsul
title	Chemical constituents from stem bark of Garcinia prainiana and their bioactivities
title_short	Chemical constituents from stem bark of Garcinia prainiana and their bioactivities
title_full	Chemical constituents from stem bark of Garcinia prainiana and their bioactivities
title_fullStr	Chemical constituents from stem bark of Garcinia prainiana and their bioactivities
title_full_unstemmed	Chemical constituents from stem bark of Garcinia prainiana and their bioactivities
title_sort	chemical constituents from stem bark of garcinia prainiana and their bioactivities
publisher	International Journal of Pharmacognosy and Phytochemical Resear
publishDate	2016
url	http://irep.iium.edu.my/50725/ http://irep.iium.edu.my/50725/ http://irep.iium.edu.my/50725/1/IJPPR%2CVol8%2CIssue5%2CArticle9.pdf http://irep.iium.edu.my/50725/4/50725_Chemical%20constituents_scopus.pdf
first_indexed	2023-09-18T21:11:44Z
last_indexed	2023-09-18T21:11:44Z
_version_	1777411297960263680

Chemical constituents from stem bark of Garcinia prainiana and their bioactivities

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