Preliminary study of the plasma and cerebrospinal fluid concentrations of IL-6 and IL-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management.

Objective. This preliminary study assessed possible relationships between plasma and/or cerebrospinal fluid (CSF) concentrations of the pleiotropic cytokine,interleukin (IL)-6, the antiinflammatory cytokine, IL-10, and levels of pain reported by patients receiving intrathecal (i.t.)opioids. Design....

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Main Authors:	Zin, Che Suraya, Nissen, Lisa M., O'Callaghan, James P., Moore, Brendan J., Smith, Maree T.
Format:	Article
Language:	English
Published:	Wiley Periodocals, Inc. 2010
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/5054/ http://irep.iium.edu.my/5054/ http://irep.iium.edu.my/5054/ http://irep.iium.edu.my/5054/1/Che_Suraya_Article_1.pdf

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recordtype	eprints
spelling	iium-50542011-09-28T08:43:07Z http://irep.iium.edu.my/5054/ Preliminary study of the plasma and cerebrospinal fluid concentrations of IL-6 and IL-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management. Zin, Che Suraya Nissen, Lisa M. O'Callaghan, James P. Moore, Brendan J. Smith, Maree T. RS Pharmacy and materia medica Objective. This preliminary study assessed possible relationships between plasma and/or cerebrospinal fluid (CSF) concentrations of the pleiotropic cytokine,interleukin (IL)-6, the antiinflammatory cytokine, IL-10, and levels of pain reported by patients receiving intrathecal (i.t.)opioids. Design. A prospective study quantifying IL-6 and IL-10 concentrations using enzyme-linked immunoassays in samples of plasma and CSF as well as assessment of pain scores in patients receiving intrathecal opioids for management of chronic noncancer pain. Setting. Outpatient pain clinics. Patients. Patients with chronic pain receiving intrathecal morphine or hydromorphone alone or in combination with local anesthetics. Interventions. Two groups of patients were studied. The first group (n = 50) had been receiving long-term i.t. opioids by chronically implanted pump for ~5 years; paired samples of plasma and CSF were collected at the time of i.t. pump refill. For the second patient group (n = 10), possible temporal changes in the plasma and/or CSF concentrations of IL-6 and IL-10 were investigated for 3 months after initiation of i.t. opioid infusions. Results. For patients receiving long-term i.t. opioid infusions, there were significant inverse correlations (P � 0.05) between pain intensity and the plasma (but not CSF) IL-10 and IL-6 concentrations. Despite the considerable inter-patient variability in the CSF concentrations of IL-6 in the long-term cohort, the mean CSF IL-6 concentration was approximately fivefold higher in patients receiving long-term i.t. opioids relative to those receiving i.t. opioids for only 3 months. Conclusions. The significant inverse correlations observed between pain intensity and the plasma IL-6 and IL-10 concentrations in patients receiving longterm i.t. opioids for chronic pain management, suggests that these cytokines are worthy of further investigation as possible biomarkers of persistent pain. Wiley Periodocals, Inc. 2010-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/5054/1/Che_Suraya_Article_1.pdf Zin, Che Suraya and Nissen, Lisa M. and O'Callaghan, James P. and Moore, Brendan J. and Smith, Maree T. (2010) Preliminary study of the plasma and cerebrospinal fluid concentrations of IL-6 and IL-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management. Pain medicine , 11 (4). pp. 550-561. ISSN 1526-4637 http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291526-4637 10.1111/j.1526-4637.2010.00821.x
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Zin, Che Suraya Nissen, Lisa M. O'Callaghan, James P. Moore, Brendan J. Smith, Maree T. Preliminary study of the plasma and cerebrospinal fluid concentrations of IL-6 and IL-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management.
description	Objective. This preliminary study assessed possible relationships between plasma and/or cerebrospinal fluid (CSF) concentrations of the pleiotropic cytokine,interleukin (IL)-6, the antiinflammatory cytokine, IL-10, and levels of pain reported by patients receiving intrathecal (i.t.)opioids. Design. A prospective study quantifying IL-6 and IL-10 concentrations using enzyme-linked immunoassays in samples of plasma and CSF as well as assessment of pain scores in patients receiving intrathecal opioids for management of chronic noncancer pain. Setting. Outpatient pain clinics. Patients. Patients with chronic pain receiving intrathecal morphine or hydromorphone alone or in combination with local anesthetics. Interventions. Two groups of patients were studied. The first group (n = 50) had been receiving long-term i.t. opioids by chronically implanted pump for ~5 years; paired samples of plasma and CSF were collected at the time of i.t. pump refill. For the second patient group (n = 10), possible temporal changes in the plasma and/or CSF concentrations of IL-6 and IL-10 were investigated for 3 months after initiation of i.t. opioid infusions. Results. For patients receiving long-term i.t. opioid infusions, there were significant inverse correlations (P � 0.05) between pain intensity and the plasma (but not CSF) IL-10 and IL-6 concentrations. Despite the considerable inter-patient variability in the CSF concentrations of IL-6 in the long-term cohort, the mean CSF IL-6 concentration was approximately fivefold higher in patients receiving long-term i.t. opioids relative to those receiving i.t. opioids for only 3 months. Conclusions. The significant inverse correlations observed between pain intensity and the plasma IL-6 and IL-10 concentrations in patients receiving longterm i.t. opioids for chronic pain management, suggests that these cytokines are worthy of further investigation as possible biomarkers of persistent pain.
format	Article
author	Zin, Che Suraya Nissen, Lisa M. O'Callaghan, James P. Moore, Brendan J. Smith, Maree T.
author_facet	Zin, Che Suraya Nissen, Lisa M. O'Callaghan, James P. Moore, Brendan J. Smith, Maree T.
author_sort	Zin, Che Suraya
title	Preliminary study of the plasma and cerebrospinal fluid concentrations of IL-6 and IL-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management.
title_short	Preliminary study of the plasma and cerebrospinal fluid concentrations of IL-6 and IL-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management.
title_full	Preliminary study of the plasma and cerebrospinal fluid concentrations of IL-6 and IL-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management.
title_fullStr	Preliminary study of the plasma and cerebrospinal fluid concentrations of IL-6 and IL-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management.
title_full_unstemmed	Preliminary study of the plasma and cerebrospinal fluid concentrations of IL-6 and IL-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management.
title_sort	preliminary study of the plasma and cerebrospinal fluid concentrations of il-6 and il-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management.
publisher	Wiley Periodocals, Inc.
publishDate	2010
url	http://irep.iium.edu.my/5054/ http://irep.iium.edu.my/5054/ http://irep.iium.edu.my/5054/ http://irep.iium.edu.my/5054/1/Che_Suraya_Article_1.pdf
first_indexed	2023-09-18T20:13:32Z
last_indexed	2023-09-18T20:13:32Z
_version_	1777407636320288768

Preliminary study of the plasma and cerebrospinal fluid concentrations of IL-6 and IL-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management.

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