A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin

The aim of this randomized double-blind, placebo-controlled, parallel-group study was to evaluate the efficacy, safety, and tolerability of pregabalin in combination with oxycodone or placebo, in patients with either postherpetic neuralgia (PHN) or painful diabetic neuropathy (PDN). After a 7-day wa...

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Main Authors:	Zin, Che Suraya, Nissen, Lisa M., O'Callaghan, James P., Duffull, Stephen B., Smith, Maree T., Moore, Brendan J.
Format:	Article
Language:	English
Published:	Elsevier 2010
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/5047/ http://irep.iium.edu.my/5047/ http://irep.iium.edu.my/5047/ http://irep.iium.edu.my/5047/1/Che_Suraya_article_2.pdf

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spelling	iium-50472011-12-06T08:28:51Z http://irep.iium.edu.my/5047/ A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin Zin, Che Suraya Nissen, Lisa M. O'Callaghan, James P. Duffull, Stephen B. Smith, Maree T. Moore, Brendan J. RS Pharmacy and materia medica The aim of this randomized double-blind, placebo-controlled, parallel-group study was to evaluate the efficacy, safety, and tolerability of pregabalin in combination with oxycodone or placebo, in patients with either postherpetic neuralgia (PHN) or painful diabetic neuropathy (PDN). After a 7-day washout period, 62 patients were randomized to receive either oxycodone mixture 10 mg/day or placebo mixture for 1 week. Patients were then started on open-label pregabalin (75, 150, 300 and 600 mg/day) according to a forced titration dosing regimen, while continuing the same dosage of oxycodone or placebo for 4 weeks. The primary efficacy measure was a decrease in the pain-intensity score of at least 2cm and a pain score <4cm measured using a 10-cm visual analogue scale (VAS) following pregabalin dosage escalation and treatment for 4 weeks. Secondary efficacy measures included sleep interference and the Neuropathic Pain Scale. There were similar levels of overall efficacy between pregabalin/oxycodone and pregabalin/placebo groups in relieving PHN and PDN related pain. PERSPECTIVE: Peripheral neuropathic pain presents commonly in clinical practice, and 2 of its most prevalent types are PHN and PDN. Currently available treatments provide some degree of pain relief in approximately 40-60% of patients, leaving the remainder with unremitting pain. Although this study supports the effectiveness of pregabalin in the treatment of PHN or PDN, it also shows that the addition of a low dose of oxycodone at 10mg/day does not enhance the pain-relieving effects of pregabalin. Elsevier 2010-05 Article PeerReviewed application/pdf en http://irep.iium.edu.my/5047/1/Che_Suraya_article_2.pdf Zin, Che Suraya and Nissen, Lisa M. and O'Callaghan, James P. and Duffull, Stephen B. and Smith, Maree T. and Moore, Brendan J. (2010) A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin. The journal of pain : official journal of the American Pain Society, 11 (5). pp. 462-471. ISSN 1528-8447 http://www.jpain.org/home DOI:10.1016/j.jpain.2009.09.003
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Zin, Che Suraya Nissen, Lisa M. O'Callaghan, James P. Duffull, Stephen B. Smith, Maree T. Moore, Brendan J. A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin
description	The aim of this randomized double-blind, placebo-controlled, parallel-group study was to evaluate the efficacy, safety, and tolerability of pregabalin in combination with oxycodone or placebo, in patients with either postherpetic neuralgia (PHN) or painful diabetic neuropathy (PDN). After a 7-day washout period, 62 patients were randomized to receive either oxycodone mixture 10 mg/day or placebo mixture for 1 week. Patients were then started on open-label pregabalin (75, 150, 300 and 600 mg/day) according to a forced titration dosing regimen, while continuing the same dosage of oxycodone or placebo for 4 weeks. The primary efficacy measure was a decrease in the pain-intensity score of at least 2cm and a pain score <4cm measured using a 10-cm visual analogue scale (VAS) following pregabalin dosage escalation and treatment for 4 weeks. Secondary efficacy measures included sleep interference and the Neuropathic Pain Scale. There were similar levels of overall efficacy between pregabalin/oxycodone and pregabalin/placebo groups in relieving PHN and PDN related pain. PERSPECTIVE: Peripheral neuropathic pain presents commonly in clinical practice, and 2 of its most prevalent types are PHN and PDN. Currently available treatments provide some degree of pain relief in approximately 40-60% of patients, leaving the remainder with unremitting pain. Although this study supports the effectiveness of pregabalin in the treatment of PHN or PDN, it also shows that the addition of a low dose of oxycodone at 10mg/day does not enhance the pain-relieving effects of pregabalin.
format	Article
author	Zin, Che Suraya Nissen, Lisa M. O'Callaghan, James P. Duffull, Stephen B. Smith, Maree T. Moore, Brendan J.
author_facet	Zin, Che Suraya Nissen, Lisa M. O'Callaghan, James P. Duffull, Stephen B. Smith, Maree T. Moore, Brendan J.
author_sort	Zin, Che Suraya
title	A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin
title_short	A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin
title_full	A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin
title_fullStr	A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin
title_full_unstemmed	A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin
title_sort	randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin
publisher	Elsevier
publishDate	2010
url	http://irep.iium.edu.my/5047/ http://irep.iium.edu.my/5047/ http://irep.iium.edu.my/5047/ http://irep.iium.edu.my/5047/1/Che_Suraya_article_2.pdf
first_indexed	2023-09-18T20:13:32Z
last_indexed	2023-09-18T20:13:32Z
_version_	1777407636024590336

A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin

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