A review on transdermal spray: formulation aspect

Transdermal spray offers numerous advantages over the other conventional transdermal drug delivery forms such as gel, ointment and patches, in terms of its cosmeceutical appearance, ready availability for application, flexibility in dosage design, less occurrence of skin irritation and faster drying...

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Main Authors:	Mandal, Uttam Kumar, Chatterjee, Bappaditya, Pauzi, Fatin Husna
Format:	Article
Language:	English
Published:	Mathews Open Access Journals 2016
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/50425/ http://irep.iium.edu.my/50425/ http://irep.iium.edu.my/50425/ http://irep.iium.edu.my/50425/1/45._Review_Transdermal_ASpray_MJPS.pdf

id	iium-50425
recordtype	eprints
spelling	iium-504252017-01-09T04:16:11Z http://irep.iium.edu.my/50425/ A review on transdermal spray: formulation aspect Mandal, Uttam Kumar Chatterjee, Bappaditya Pauzi, Fatin Husna RS Pharmacy and materia medica Transdermal spray offers numerous advantages over the other conventional transdermal drug delivery forms such as gel, ointment and patches, in terms of its cosmeceutical appearance, ready availability for application, flexibility in dosage design, less occurrence of skin irritation and faster drying rate from the application site due to the use of volatile solvent. However, compared to other transdermal drug delivery dosage forms, transdermal spray has the least and limited number of products approved for marketing. Among the drugs are, Evamist®, an estradiol formulation approved in 2007 by the FDA followed by Axiron® a non-spray solution to treat low testosterone in men and Recuvyra®, a pain reliever solution indicated for dogs. This review article focuses current status on the formulation and evaluation of transdermal spray in the background of the role and effects of its composition specially the selection of drugs, volatile solvents, penetration enhancers and film forming polymer, etc. The limitation of transdermal spray highlighted in this review is the concern of its use, especially, the third party exposure particularly for endocrinology indication. Moreover, transdermal spray is also restricted in drugs with large doses due to the limited diffusivity into the skin. The difficulty of exploiting hydrophilic drugs like peptides, macromolecules and new genetic treatments using DNA or small-interfering RNA (siRNA) into transdermal spray formulations is also a limitation that needs to be explored in depth. Mathews Open Access Journals 2016-03-30 Article NonPeerReviewed application/pdf en http://irep.iium.edu.my/50425/1/45._Review_Transdermal_ASpray_MJPS.pdf Mandal, Uttam Kumar and Chatterjee, Bappaditya and Pauzi, Fatin Husna (2016) A review on transdermal spray: formulation aspect. Mathews Journal of Pharmaceutical Science, 1 (1). pp. 1-12. ISSN 2474-753X http://mathewsopenaccess.com/PDF/pharmaceutical-science/M_J_Pharma_1_1_006.pdf 006
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Mandal, Uttam Kumar Chatterjee, Bappaditya Pauzi, Fatin Husna A review on transdermal spray: formulation aspect
description	Transdermal spray offers numerous advantages over the other conventional transdermal drug delivery forms such as gel, ointment and patches, in terms of its cosmeceutical appearance, ready availability for application, flexibility in dosage design, less occurrence of skin irritation and faster drying rate from the application site due to the use of volatile solvent. However, compared to other transdermal drug delivery dosage forms, transdermal spray has the least and limited number of products approved for marketing. Among the drugs are, Evamist®, an estradiol formulation approved in 2007 by the FDA followed by Axiron® a non-spray solution to treat low testosterone in men and Recuvyra®, a pain reliever solution indicated for dogs. This review article focuses current status on the formulation and evaluation of transdermal spray in the background of the role and effects of its composition specially the selection of drugs, volatile solvents, penetration enhancers and film forming polymer, etc. The limitation of transdermal spray highlighted in this review is the concern of its use, especially, the third party exposure particularly for endocrinology indication. Moreover, transdermal spray is also restricted in drugs with large doses due to the limited diffusivity into the skin. The difficulty of exploiting hydrophilic drugs like peptides, macromolecules and new genetic treatments using DNA or small-interfering RNA (siRNA) into transdermal spray formulations is also a limitation that needs to be explored in depth.
format	Article
author	Mandal, Uttam Kumar Chatterjee, Bappaditya Pauzi, Fatin Husna
author_facet	Mandal, Uttam Kumar Chatterjee, Bappaditya Pauzi, Fatin Husna
author_sort	Mandal, Uttam Kumar
title	A review on transdermal spray: formulation aspect
title_short	A review on transdermal spray: formulation aspect
title_full	A review on transdermal spray: formulation aspect
title_fullStr	A review on transdermal spray: formulation aspect
title_full_unstemmed	A review on transdermal spray: formulation aspect
title_sort	review on transdermal spray: formulation aspect
publisher	Mathews Open Access Journals
publishDate	2016
url	http://irep.iium.edu.my/50425/ http://irep.iium.edu.my/50425/ http://irep.iium.edu.my/50425/ http://irep.iium.edu.my/50425/1/45._Review_Transdermal_ASpray_MJPS.pdf
first_indexed	2023-09-18T21:11:17Z
last_indexed	2023-09-18T21:11:17Z
_version_	1777411269248155648

A review on transdermal spray: formulation aspect

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