Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines

Background: Garcinia xanthochymus extract has been reported to have several pharmacological properties. This study was conducted to evaluate cytotoxic and anti-inflammatory activities of G. xanthochymus extracts on cell lines. Methods: The roots and stem barks of plant were extracted using maceratio...

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Main Authors:	Hamidon, Hanisuhana, Bakhtiar, M. Taher, Md. Jaffri, Julian, Tg Zakaria, Tg Muhammad Faris Syafiq, Wan Sulaiman, Wan Mohd Azizi, Darnis, Deny Susanti, Ichwan, Solachuddin Jauhari Arief, Zakaria, Zainul Amiruddin
Format:	Article
Language:	English English
Published:	Directorate of Research and Public Services Universitas Indonesia 2016
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/50327/ http://irep.iium.edu.my/50327/ http://irep.iium.edu.my/50327/ http://irep.iium.edu.my/50327/1/Makara-5599-10849-1-PB.pdf http://irep.iium.edu.my/50327/4/50327_Cytotoxic%20and%20anti-inflammatory_wos.pdf

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recordtype	eprints
spelling	iium-503272017-10-03T07:25:14Z http://irep.iium.edu.my/50327/ Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines Hamidon, Hanisuhana Bakhtiar, M. Taher Md. Jaffri, Julian Tg Zakaria, Tg Muhammad Faris Syafiq Wan Sulaiman, Wan Mohd Azizi Darnis, Deny Susanti Ichwan, Solachuddin Jauhari Arief Zakaria, Zainul Amiruddin RS Pharmacy and materia medica Background: Garcinia xanthochymus extract has been reported to have several pharmacological properties. This study was conducted to evaluate cytotoxic and anti-inflammatory activities of G. xanthochymus extracts on cell lines. Methods: The roots and stem barks of plant were extracted using maceration method with n-hexane, dichloromethane and methanol, successively. Cytotoxic activity of the extracts was tested against MCF-7 breast adenocarcinoma using MTT assay. Anti-inflammatory study was evaluated using RAW 264.7 mouse macrophage cells. The nitric oxide production in LPS-stimulated cells was measured using Griess reagent. Results: The results of cytotoxic and anti-inflammatory study showed that dichloromethane and n-hexane extracts of root and stem bark exhibited cytotoxic activity in dose-dependent manner. Meanwhile, for anti-inflammatory study, all root extracts together with stem bark dichloromethane and n-hexane extracts reduce NO production in LPS-stimulated cells in dose dependent manner. Conclusion: This finding indicated that G. xanthochymus extracts might become interesting candidate for treatment of cancer and inflammation. Directorate of Research and Public Services Universitas Indonesia 2016-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/50327/1/Makara-5599-10849-1-PB.pdf application/pdf en http://irep.iium.edu.my/50327/4/50327_Cytotoxic%20and%20anti-inflammatory_wos.pdf Hamidon, Hanisuhana and Bakhtiar, M. Taher and Md. Jaffri, Julian and Tg Zakaria, Tg Muhammad Faris Syafiq and Wan Sulaiman, Wan Mohd Azizi and Darnis, Deny Susanti and Ichwan, Solachuddin Jauhari Arief and Zakaria, Zainul Amiruddin (2016) Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines. Makara Journal of Health Research, 20 (1). pp. 11-17. ISSN 2356-3664 E-ISSN 2356-3656 http://journal.ui.ac.id/index.php/health/article/view/5599/3624 10.7454/msk.v20i1.5599
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Hamidon, Hanisuhana Bakhtiar, M. Taher Md. Jaffri, Julian Tg Zakaria, Tg Muhammad Faris Syafiq Wan Sulaiman, Wan Mohd Azizi Darnis, Deny Susanti Ichwan, Solachuddin Jauhari Arief Zakaria, Zainul Amiruddin Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines
description	Background: Garcinia xanthochymus extract has been reported to have several pharmacological properties. This study was conducted to evaluate cytotoxic and anti-inflammatory activities of G. xanthochymus extracts on cell lines. Methods: The roots and stem barks of plant were extracted using maceration method with n-hexane, dichloromethane and methanol, successively. Cytotoxic activity of the extracts was tested against MCF-7 breast adenocarcinoma using MTT assay. Anti-inflammatory study was evaluated using RAW 264.7 mouse macrophage cells. The nitric oxide production in LPS-stimulated cells was measured using Griess reagent. Results: The results of cytotoxic and anti-inflammatory study showed that dichloromethane and n-hexane extracts of root and stem bark exhibited cytotoxic activity in dose-dependent manner. Meanwhile, for anti-inflammatory study, all root extracts together with stem bark dichloromethane and n-hexane extracts reduce NO production in LPS-stimulated cells in dose dependent manner. Conclusion: This finding indicated that G. xanthochymus extracts might become interesting candidate for treatment of cancer and inflammation.
format	Article
author	Hamidon, Hanisuhana Bakhtiar, M. Taher Md. Jaffri, Julian Tg Zakaria, Tg Muhammad Faris Syafiq Wan Sulaiman, Wan Mohd Azizi Darnis, Deny Susanti Ichwan, Solachuddin Jauhari Arief Zakaria, Zainul Amiruddin
author_facet	Hamidon, Hanisuhana Bakhtiar, M. Taher Md. Jaffri, Julian Tg Zakaria, Tg Muhammad Faris Syafiq Wan Sulaiman, Wan Mohd Azizi Darnis, Deny Susanti Ichwan, Solachuddin Jauhari Arief Zakaria, Zainul Amiruddin
author_sort	Hamidon, Hanisuhana
title	Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines
title_short	Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines
title_full	Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines
title_fullStr	Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines
title_full_unstemmed	Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines
title_sort	cytotoxic and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines
publisher	Directorate of Research and Public Services Universitas Indonesia
publishDate	2016
url	http://irep.iium.edu.my/50327/ http://irep.iium.edu.my/50327/ http://irep.iium.edu.my/50327/ http://irep.iium.edu.my/50327/1/Makara-5599-10849-1-PB.pdf http://irep.iium.edu.my/50327/4/50327_Cytotoxic%20and%20anti-inflammatory_wos.pdf
first_indexed	2023-09-18T21:11:08Z
last_indexed	2023-09-18T21:11:08Z
_version_	1777411260047949824

Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines

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