Cytotoxic and anti-inflammatory activities of Garcinia xanthochymus extracts on cell lines
Background: Garcinia xanthochymus extract has been reported to have several pharmacological properties. This study was conducted to evaluate cytotoxic and anti-inflammatory activities of G. xanthochymus extracts on cell lines. Methods: The roots and stem barks of plant were extracted using maceratio...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Directorate of Research and Public Services Universitas Indonesia
2016
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/50327/ http://irep.iium.edu.my/50327/ http://irep.iium.edu.my/50327/ http://irep.iium.edu.my/50327/1/Makara-5599-10849-1-PB.pdf http://irep.iium.edu.my/50327/4/50327_Cytotoxic%20and%20anti-inflammatory_wos.pdf |
| Summary: | Background: Garcinia xanthochymus extract has been reported to have several pharmacological properties. This study was conducted to evaluate cytotoxic and anti-inflammatory activities of G. xanthochymus extracts on cell lines. Methods: The roots and stem barks of plant were extracted using maceration method with n-hexane, dichloromethane and methanol, successively. Cytotoxic activity of the extracts was tested against MCF-7 breast adenocarcinoma using MTT assay. Anti-inflammatory study was evaluated using RAW 264.7 mouse macrophage cells. The nitric oxide production in LPS-stimulated cells was measured using Griess reagent. Results: The results of cytotoxic and anti-inflammatory study showed that dichloromethane and n-hexane extracts of root and stem bark exhibited cytotoxic activity in dose-dependent manner. Meanwhile, for anti-inflammatory study, all root extracts together with stem bark dichloromethane and n-hexane extracts reduce NO production in LPS-stimulated cells in dose dependent manner. Conclusion: This finding indicated that G. xanthochymus extracts might become interesting candidate for treatment of cancer and inflammation. |
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