Role of pharmacodiagnostic of CYP2C9 variants in the optimization of warfarin therapy in Malaysia: a 6-month follow-up study

1. A retrospective study was conducted to explore the importance of CYP2C9 genotyping for the initiation and maintenance therapy of warfarin in clinical practice. A total of 191 patients on warfarin therapy in a local hospital were recruited after written informed consent. Their medical records were...

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Main Authors:	Ngow, Harris Abdullah, Teh , Lay Kek, Langmia, I. M., Lew, W. L., Harun, R., Ismail, R., Salleh, Mohd Zaki
Format:	Article
Language:	English
Published:	Informa Plc. 2008
Subjects:	RC Internal medicine RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/5015/ http://irep.iium.edu.my/5015/ http://irep.iium.edu.my/5015/ http://irep.iium.edu.my/5015/1/Xenobiotica_Warfarin_Study.pdf

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recordtype	eprints
spelling	iium-50152013-06-10T08:03:25Z http://irep.iium.edu.my/5015/ Role of pharmacodiagnostic of CYP2C9 variants in the optimization of warfarin therapy in Malaysia: a 6-month follow-up study Ngow, Harris Abdullah Teh , Lay Kek Langmia, I. M. Lew, W. L. Harun, R. Ismail, R. Salleh, Mohd Zaki RC Internal medicine RM Therapeutics. Pharmacology 1. A retrospective study was conducted to explore the importance of CYP2C9 genotyping for the initiation and maintenance therapy of warfarin in clinical practice. A total of 191 patients on warfarin therapy in a local hospital were recruited after written informed consent. Their medical records were reviewed and no intervention of warfarin dose was performed. 2. A total of 5 ml of blood were taken from each subject for DNA extraction and identification of 1, 2, 3 and 4 CYP2C9 alleles, using a nested-allele-specific-multiplex-polymerase chain reaction (PCR). Half the patients were Malays and the remaining were Chinese. 3. Two genotypes were detected; 93.2% had CYP2C9 1/1 and 6.8% were CYP2C9 1/3. Warfarin doses were higher in patients with CYP2C91/1. Patients with the 1/3 genotype experienced a higher rate of serious and life-threatening bleeding; 15.4 versus 6.2 per 100 patients per 6 months. 4. The observation clearly highlights the inadequacy of the current dosing regimens and the need to move toward a more individualized approach to warfarin therapy. Prospective clinical studies are now being conducted to assess dosing algorithms that incorporate the contribution of the genotype to allow the individualization of warfarin dose. Informa Plc. 2008 Article PeerReviewed application/pdf en http://irep.iium.edu.my/5015/1/Xenobiotica_Warfarin_Study.pdf Ngow, Harris Abdullah and Teh , Lay Kek and Langmia, I. M. and Lew, W. L. and Harun, R. and Ismail, R. and Salleh, Mohd Zaki (2008) Role of pharmacodiagnostic of CYP2C9 variants in the optimization of warfarin therapy in Malaysia: a 6-month follow-up study. Xenobiotica, 38 (6). pp. 641-651. ISSN 0049-8254 http://informahealthcare.com/doi/abs/10.1080/00498250801999087%20 10.1080/00498250801999087
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RC Internal medicine RM Therapeutics. Pharmacology
spellingShingle	RC Internal medicine RM Therapeutics. Pharmacology Ngow, Harris Abdullah Teh , Lay Kek Langmia, I. M. Lew, W. L. Harun, R. Ismail, R. Salleh, Mohd Zaki Role of pharmacodiagnostic of CYP2C9 variants in the optimization of warfarin therapy in Malaysia: a 6-month follow-up study
description	1. A retrospective study was conducted to explore the importance of CYP2C9 genotyping for the initiation and maintenance therapy of warfarin in clinical practice. A total of 191 patients on warfarin therapy in a local hospital were recruited after written informed consent. Their medical records were reviewed and no intervention of warfarin dose was performed. 2. A total of 5 ml of blood were taken from each subject for DNA extraction and identification of 1, 2, 3 and 4 CYP2C9 alleles, using a nested-allele-specific-multiplex-polymerase chain reaction (PCR). Half the patients were Malays and the remaining were Chinese. 3. Two genotypes were detected; 93.2% had CYP2C9 1/1 and 6.8% were CYP2C9 1/3. Warfarin doses were higher in patients with CYP2C91/1. Patients with the 1/3 genotype experienced a higher rate of serious and life-threatening bleeding; 15.4 versus 6.2 per 100 patients per 6 months. 4. The observation clearly highlights the inadequacy of the current dosing regimens and the need to move toward a more individualized approach to warfarin therapy. Prospective clinical studies are now being conducted to assess dosing algorithms that incorporate the contribution of the genotype to allow the individualization of warfarin dose.
format	Article
author	Ngow, Harris Abdullah Teh , Lay Kek Langmia, I. M. Lew, W. L. Harun, R. Ismail, R. Salleh, Mohd Zaki
author_facet	Ngow, Harris Abdullah Teh , Lay Kek Langmia, I. M. Lew, W. L. Harun, R. Ismail, R. Salleh, Mohd Zaki
author_sort	Ngow, Harris Abdullah
title	Role of pharmacodiagnostic of CYP2C9 variants in the optimization of warfarin therapy in Malaysia: a 6-month follow-up study
title_short	Role of pharmacodiagnostic of CYP2C9 variants in the optimization of warfarin therapy in Malaysia: a 6-month follow-up study
title_full	Role of pharmacodiagnostic of CYP2C9 variants in the optimization of warfarin therapy in Malaysia: a 6-month follow-up study
title_fullStr	Role of pharmacodiagnostic of CYP2C9 variants in the optimization of warfarin therapy in Malaysia: a 6-month follow-up study
title_full_unstemmed	Role of pharmacodiagnostic of CYP2C9 variants in the optimization of warfarin therapy in Malaysia: a 6-month follow-up study
title_sort	role of pharmacodiagnostic of cyp2c9 variants in the optimization of warfarin therapy in malaysia: a 6-month follow-up study
publisher	Informa Plc.
publishDate	2008
url	http://irep.iium.edu.my/5015/ http://irep.iium.edu.my/5015/ http://irep.iium.edu.my/5015/ http://irep.iium.edu.my/5015/1/Xenobiotica_Warfarin_Study.pdf
first_indexed	2023-09-18T20:13:28Z
last_indexed	2023-09-18T20:13:28Z
_version_	1777407631933046784

Role of pharmacodiagnostic of CYP2C9 variants in the optimization of warfarin therapy in Malaysia: a 6-month follow-up study

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