Agarwood leaf essential oil characterization and effects on MCF-7 breast cancer cells

Breast cancer continues to remain as the leading cause of cancer mortality among women worldwide. Agents for prevention and cure for breast cancer are contiuously being researched. İn particular, agarwood essential oil from resin infiltrated heartwood has been reported to have substantial evidences...

Full description

Bibliographic Details
Main Authors:	Zainurin, Nur Aimi Aliah, Hashim, Yumi Zuhanis Has-Yun, Mohamed Azmin, Nor Fadhillah, Abbas, Phirdaous
Format:	Article
Language:	English English
Published:	Indonesian Society for Knowledge and Human Development (INSIGHT) 2018
Subjects:	R Medicine (General) TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/50137/ http://irep.iium.edu.my/50137/ http://irep.iium.edu.my/50137/ http://irep.iium.edu.my/50137/1/50137_Agarwood%20Leaf%20Essential%20Oil%20Characterization.pdf http://irep.iium.edu.my/50137/7/50137_Agarwood%20leaf%20essential%20oil%20characterization_SCOPUS.pdf

id	iium-50137
recordtype	eprints
spelling	iium-501372018-12-31T11:14:02Z http://irep.iium.edu.my/50137/ Agarwood leaf essential oil characterization and effects on MCF-7 breast cancer cells Zainurin, Nur Aimi Aliah Hashim, Yumi Zuhanis Has-Yun Mohamed Azmin, Nor Fadhillah Abbas, Phirdaous R Medicine (General) TP248.13 Biotechnology Breast cancer continues to remain as the leading cause of cancer mortality among women worldwide. Agents for prevention and cure for breast cancer are contiuously being researched. İn particular, agarwood essential oil from resin infiltrated heartwood has been reported to have substantial evidences of medicinal benefits. Nevertheless, there is very limited report on agarwood leaf essential oil (ALEO). Hence, this present study was conducted to evaluate the physicochemical properties, chemical constituents and anticancer activity of ALEO. ALEO was observed to be of pale-yellow colour with sweet smell. Other physicochemical properties include refractive index of 1.44, specific gravity of 0.886, saponification value of 131.88 mg KOH/g, acid value of 2.80 mg KOH/g and iodine value of 105.07 gI2/100g. The profiling of chemical constituents using gas chromatography-mass spectrometry (GCMS) revealed 19 compounds. Hexadecanoic acid was the major compound (64.41%). The biomarkers of agarwood; azulene (0.619%) and guaiol (0.2997%) were also detected. ALEO was tested for anticancer activity against MCF-7 cancer cells using WST-8 assay. ALEO showed the IC50 value of 31% (v/v) against MCF-7 cells after 36 hours of treatment. In conclusion, this study provides information on ALEO physicochemical properties and chemical constituents that can be used as benchmark for quality assurance as well as proof that ALEO holds a potential as anticancer agent. Indonesian Society for Knowledge and Human Development (INSIGHT) 2018 Article PeerReviewed application/pdf en http://irep.iium.edu.my/50137/1/50137_Agarwood%20Leaf%20Essential%20Oil%20Characterization.pdf application/pdf en http://irep.iium.edu.my/50137/7/50137_Agarwood%20leaf%20essential%20oil%20characterization_SCOPUS.pdf Zainurin, Nur Aimi Aliah and Hashim, Yumi Zuhanis Has-Yun and Mohamed Azmin, Nor Fadhillah and Abbas, Phirdaous (2018) Agarwood leaf essential oil characterization and effects on MCF-7 breast cancer cells. International Journal on Advanced Science, Engineering and Information Technology, 8 (4-2). pp. 1604-1609. E-ISSN 2088-5334 http://insightsociety.org/ojaseit/index.php/ijaseit/article/view/7034/pdf_838 10.18517/ijaseit.8.4-2.7034
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General) TP248.13 Biotechnology
spellingShingle	R Medicine (General) TP248.13 Biotechnology Zainurin, Nur Aimi Aliah Hashim, Yumi Zuhanis Has-Yun Mohamed Azmin, Nor Fadhillah Abbas, Phirdaous Agarwood leaf essential oil characterization and effects on MCF-7 breast cancer cells
description	Breast cancer continues to remain as the leading cause of cancer mortality among women worldwide. Agents for prevention and cure for breast cancer are contiuously being researched. İn particular, agarwood essential oil from resin infiltrated heartwood has been reported to have substantial evidences of medicinal benefits. Nevertheless, there is very limited report on agarwood leaf essential oil (ALEO). Hence, this present study was conducted to evaluate the physicochemical properties, chemical constituents and anticancer activity of ALEO. ALEO was observed to be of pale-yellow colour with sweet smell. Other physicochemical properties include refractive index of 1.44, specific gravity of 0.886, saponification value of 131.88 mg KOH/g, acid value of 2.80 mg KOH/g and iodine value of 105.07 gI2/100g. The profiling of chemical constituents using gas chromatography-mass spectrometry (GCMS) revealed 19 compounds. Hexadecanoic acid was the major compound (64.41%). The biomarkers of agarwood; azulene (0.619%) and guaiol (0.2997%) were also detected. ALEO was tested for anticancer activity against MCF-7 cancer cells using WST-8 assay. ALEO showed the IC50 value of 31% (v/v) against MCF-7 cells after 36 hours of treatment. In conclusion, this study provides information on ALEO physicochemical properties and chemical constituents that can be used as benchmark for quality assurance as well as proof that ALEO holds a potential as anticancer agent.
format	Article
author	Zainurin, Nur Aimi Aliah Hashim, Yumi Zuhanis Has-Yun Mohamed Azmin, Nor Fadhillah Abbas, Phirdaous
author_facet	Zainurin, Nur Aimi Aliah Hashim, Yumi Zuhanis Has-Yun Mohamed Azmin, Nor Fadhillah Abbas, Phirdaous
author_sort	Zainurin, Nur Aimi Aliah
title	Agarwood leaf essential oil characterization and effects on MCF-7 breast cancer cells
title_short	Agarwood leaf essential oil characterization and effects on MCF-7 breast cancer cells
title_full	Agarwood leaf essential oil characterization and effects on MCF-7 breast cancer cells
title_fullStr	Agarwood leaf essential oil characterization and effects on MCF-7 breast cancer cells
title_full_unstemmed	Agarwood leaf essential oil characterization and effects on MCF-7 breast cancer cells
title_sort	agarwood leaf essential oil characterization and effects on mcf-7 breast cancer cells
publisher	Indonesian Society for Knowledge and Human Development (INSIGHT)
publishDate	2018
url	http://irep.iium.edu.my/50137/ http://irep.iium.edu.my/50137/ http://irep.iium.edu.my/50137/ http://irep.iium.edu.my/50137/1/50137_Agarwood%20Leaf%20Essential%20Oil%20Characterization.pdf http://irep.iium.edu.my/50137/7/50137_Agarwood%20leaf%20essential%20oil%20characterization_SCOPUS.pdf
first_indexed	2023-09-18T21:10:50Z
last_indexed	2023-09-18T21:10:50Z
_version_	1777411241758687232

Agarwood leaf essential oil characterization and effects on MCF-7 breast cancer cells

Similar Items