Coumarins and chromanones from two Calophyllum species and their bioactivities

Calophyllum is a pan-tropical genus belongs to the Guttiferae family and locally known by Malay local folks as'bintangor'. There has been a continrnl interest to further investigate the phytochemicals of Calophyllurn species since this genus is a rich source of active secondary metabolit...

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Main Authors:	Aminudin, Nurul Iman, Ahmad, Farediah, Bakhtiar, M. Taher, Mohamed Zulkifli, Razauden
Format:	Conference or Workshop Item
Language:	English
Published:	2016
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/50095/ http://irep.iium.edu.my/50095/ http://irep.iium.edu.my/50095/4/50095-new.pdf

id	iium-50095
recordtype	eprints
spelling	iium-500952018-05-23T03:32:59Z http://irep.iium.edu.my/50095/ Coumarins and chromanones from two Calophyllum species and their bioactivities Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Razauden RS Pharmacy and materia medica Calophyllum is a pan-tropical genus belongs to the Guttiferae family and locally known by Malay local folks as'bintangor'. There has been a continrnl interest to further investigate the phytochemicals of Calophyllurn species since this genus is a rich source of active secondary metabolites which showed anti-HIV, cytotoxicity and antimicrobial properties. In this study, phytochemicals studies on the barks and leaves of Calophyllum symingtonianum M. R. Henderson & Wyatt-Smith and Calophyllum ferrugineum Ridley were carried out. Cold extraction method was employed by using dichloromethane, ethyl acetate and methanol to give the respective crude exracts. Three counurins known as inophyllum D, inophyllum H and calanone as well as a chronranone known as isocordateoblongic acid were isolated from the dichloromethane extract of C. symingtoniotum. Another two chromanones identified as apetalic acid and isoapetalic acid were yielded from dichloromethane extract from barks of C. ferrugineum. The structures were elucidated by spectral analysis including NMR and MS. All compounds were tested for their antibacterial, cytotoxic and alpha-glucosidase inhibition activities. All chromanones moderately inhibited the growth of Gram positive bacteria, B. subtilis and S. outeus with MIC value in the range of 3l .25 - 125 mcg/mL. Inophyllum H was forurd to be cytotoxic towards MCF-7 (IC50 25.26 pgmL) and 4-549 (IC50 26.41 pgml) cancer cell lines. Inophyllum D showed the strongest a-glucosidase inhibition with ICso 35.7 microM, followed by inophyllum H (ICso 62.30 microM) and calanone (IC50 > 100 microM). 2016-03-15 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/50095/4/50095-new.pdf Aminudin, Nurul Iman and Ahmad, Farediah and Bakhtiar, M. Taher and Mohamed Zulkifli, Razauden (2016) Coumarins and chromanones from two Calophyllum species and their bioactivities. In: International Conference on Natural Products 2016 (ICNP 2016), 15th-17th March 2016, Kuala Terengganu, Terengganu, Malaysia. (Unpublished) http://icnp2016.umt.edu.my/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Razauden Coumarins and chromanones from two Calophyllum species and their bioactivities
description	Calophyllum is a pan-tropical genus belongs to the Guttiferae family and locally known by Malay local folks as'bintangor'. There has been a continrnl interest to further investigate the phytochemicals of Calophyllurn species since this genus is a rich source of active secondary metabolites which showed anti-HIV, cytotoxicity and antimicrobial properties. In this study, phytochemicals studies on the barks and leaves of Calophyllum symingtonianum M. R. Henderson & Wyatt-Smith and Calophyllum ferrugineum Ridley were carried out. Cold extraction method was employed by using dichloromethane, ethyl acetate and methanol to give the respective crude exracts. Three counurins known as inophyllum D, inophyllum H and calanone as well as a chronranone known as isocordateoblongic acid were isolated from the dichloromethane extract of C. symingtoniotum. Another two chromanones identified as apetalic acid and isoapetalic acid were yielded from dichloromethane extract from barks of C. ferrugineum. The structures were elucidated by spectral analysis including NMR and MS. All compounds were tested for their antibacterial, cytotoxic and alpha-glucosidase inhibition activities. All chromanones moderately inhibited the growth of Gram positive bacteria, B. subtilis and S. outeus with MIC value in the range of 3l .25 - 125 mcg/mL. Inophyllum H was forurd to be cytotoxic towards MCF-7 (IC50 25.26 pgmL) and 4-549 (IC50 26.41 pgml) cancer cell lines. Inophyllum D showed the strongest a-glucosidase inhibition with ICso 35.7 microM, followed by inophyllum H (ICso 62.30 microM) and calanone (IC50 > 100 microM).
format	Conference or Workshop Item
author	Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Razauden
author_facet	Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Razauden
author_sort	Aminudin, Nurul Iman
title	Coumarins and chromanones from two Calophyllum species and their bioactivities
title_short	Coumarins and chromanones from two Calophyllum species and their bioactivities
title_full	Coumarins and chromanones from two Calophyllum species and their bioactivities
title_fullStr	Coumarins and chromanones from two Calophyllum species and their bioactivities
title_full_unstemmed	Coumarins and chromanones from two Calophyllum species and their bioactivities
title_sort	coumarins and chromanones from two calophyllum species and their bioactivities
publishDate	2016
url	http://irep.iium.edu.my/50095/ http://irep.iium.edu.my/50095/ http://irep.iium.edu.my/50095/4/50095-new.pdf
first_indexed	2023-09-18T21:10:47Z
last_indexed	2023-09-18T21:10:47Z
_version_	1777411237891538944

Coumarins and chromanones from two Calophyllum species and their bioactivities

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