Cytotoxic and antibacterial activities of constituents from Calophyllum ferrugineum ridley

This study evaluated the chemical composition of Calophyllum ferrugineum, cytotoxicity against human breast cancer (MCF-7) and human lung carcinoma (A-549) cell lines as well as antibacterial activities against two Gram-positive bacteria, S. aureus and B. subtilis and two Gram-negative bacteria, P....

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Main Authors:	Aminudin, Nurul Iman, Ahmad, Farediah, Bakhtiar, M. Taher, Mohamed Zulkifli, Razauden
Format:	Article
Language:	English English
Published:	ACG Publications 2016
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/50076/ http://irep.iium.edu.my/50076/ http://irep.iium.edu.my/50076/1/79-RNP-1511-243.pdf http://irep.iium.edu.my/50076/4/50076_Cytotoxic%20and%20antibacterial_wos_scopus.pdf

id	iium-50076
recordtype	eprints
spelling	iium-500762017-04-10T07:41:20Z http://irep.iium.edu.my/50076/ Cytotoxic and antibacterial activities of constituents from Calophyllum ferrugineum ridley Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Razauden RS Pharmacy and materia medica This study evaluated the chemical composition of Calophyllum ferrugineum, cytotoxicity against human breast cancer (MCF-7) and human lung carcinoma (A-549) cell lines as well as antibacterial activities against two Gram-positive bacteria, S. aureus and B. subtilis and two Gram-negative bacteria, P. aeruginosa and E. coli. Phytochemical investigations of the bark extract yielded isoapetalic acid (1), apetalic acid (2), 6-hydroxy-2-methoxyxanthone (3) and ent-epicatechin (4). Meanwhile, betulinic acid (5), protocatechuic acid (6) and amentoflavone (7) were isolated from the leave extract. Isoapetalic acid (1) and apetalic acid (2) exhibited cytotoxic activities towards both cancer cell lines and both Gram-positive bacteria. Compounds (3-7) were inactive or showed moderate activities towards cytotoxic and antibacterial tests. This study presents the first report on the phytochemicals investigation from C. ferrugineum and all compounds are reported for the first time from this source. ACG Publications 2016-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/50076/1/79-RNP-1511-243.pdf application/pdf en http://irep.iium.edu.my/50076/4/50076_Cytotoxic%20and%20antibacterial_wos_scopus.pdf Aminudin, Nurul Iman and Ahmad, Farediah and Bakhtiar, M. Taher and Mohamed Zulkifli, Razauden (2016) Cytotoxic and antibacterial activities of constituents from Calophyllum ferrugineum ridley. Records of Natural Products, 10 (5). pp. 649-653. ISSN 1307-6167 http://www.acgpubs.org/RNP/2016/Volume10/Issue%201/79-RNP-1511-243.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Razauden Cytotoxic and antibacterial activities of constituents from Calophyllum ferrugineum ridley
description	This study evaluated the chemical composition of Calophyllum ferrugineum, cytotoxicity against human breast cancer (MCF-7) and human lung carcinoma (A-549) cell lines as well as antibacterial activities against two Gram-positive bacteria, S. aureus and B. subtilis and two Gram-negative bacteria, P. aeruginosa and E. coli. Phytochemical investigations of the bark extract yielded isoapetalic acid (1), apetalic acid (2), 6-hydroxy-2-methoxyxanthone (3) and ent-epicatechin (4). Meanwhile, betulinic acid (5), protocatechuic acid (6) and amentoflavone (7) were isolated from the leave extract. Isoapetalic acid (1) and apetalic acid (2) exhibited cytotoxic activities towards both cancer cell lines and both Gram-positive bacteria. Compounds (3-7) were inactive or showed moderate activities towards cytotoxic and antibacterial tests. This study presents the first report on the phytochemicals investigation from C. ferrugineum and all compounds are reported for the first time from this source.
format	Article
author	Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Razauden
author_facet	Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Razauden
author_sort	Aminudin, Nurul Iman
title	Cytotoxic and antibacterial activities of constituents from Calophyllum ferrugineum ridley
title_short	Cytotoxic and antibacterial activities of constituents from Calophyllum ferrugineum ridley
title_full	Cytotoxic and antibacterial activities of constituents from Calophyllum ferrugineum ridley
title_fullStr	Cytotoxic and antibacterial activities of constituents from Calophyllum ferrugineum ridley
title_full_unstemmed	Cytotoxic and antibacterial activities of constituents from Calophyllum ferrugineum ridley
title_sort	cytotoxic and antibacterial activities of constituents from calophyllum ferrugineum ridley
publisher	ACG Publications
publishDate	2016
url	http://irep.iium.edu.my/50076/ http://irep.iium.edu.my/50076/ http://irep.iium.edu.my/50076/1/79-RNP-1511-243.pdf http://irep.iium.edu.my/50076/4/50076_Cytotoxic%20and%20antibacterial_wos_scopus.pdf
first_indexed	2023-09-18T21:10:46Z
last_indexed	2023-09-18T21:10:46Z
_version_	1777411236604936192

Cytotoxic and antibacterial activities of constituents from Calophyllum ferrugineum ridley

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