Rapid investigation of α-glucosidase inhibitory activity of Clinacanthus nutans leaf using infrared fingerprinting

The analytical method used in the quality control of Clinacanthus nutans leaves has not been well developed. Therefore, this study aimed to develop a simple analytical method to predict α-glucosidase inhibitory activity of this herb based on its infrared fingerprinting. The dried extracts obtained f...

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Main Authors:	Murugesu, Suganya, Ahmed, Qamar Uddin, Uzir, Bisha Fathamah, Nik Yusof, Nik Idris, Perumal, Vikneswari, Ibrahim, Zalikha, Abas, Faridah, Shaari, Khozirah, Khatib, Alfi
Format:	Article
Language:	English English English
Published:	Elsevier B.V. 2019
Subjects:	RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/49730/ http://irep.iium.edu.my/49730/ http://irep.iium.edu.my/49730/ http://irep.iium.edu.my/49730/1/49730_Rapid%20investigation%20of%20%CE%B1-glucosidase.pdf http://irep.iium.edu.my/49730/2/49730_Rapid%20investigation%20of%20%CE%B1-glucosidase_SCOPUS.pdf http://irep.iium.edu.my/49730/3/49730_Rapid%20investigation%20of%20%CE%B1-glucosidase_WOS.pdf

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recordtype	eprints
spelling	iium-497302019-07-12T07:13:20Z http://irep.iium.edu.my/49730/ Rapid investigation of α-glucosidase inhibitory activity of Clinacanthus nutans leaf using infrared fingerprinting Murugesu, Suganya Ahmed, Qamar Uddin Uzir, Bisha Fathamah Nik Yusof, Nik Idris Perumal, Vikneswari Ibrahim, Zalikha Abas, Faridah Shaari, Khozirah Khatib, Alfi RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry The analytical method used in the quality control of Clinacanthus nutans leaves has not been well developed. Therefore, this study aimed to develop a simple analytical method to predict α-glucosidase inhibitory activity of this herb based on its infrared fingerprinting. The dried extracts obtained from maceration using solvents with different polarities were evaluated for the α-glucosidase inhibitory activity and analysed through infrared spectroscopy. Multivariate data analysis was performed by correlating the bioactivity and infrared spectrum of each extract using partial least square method. The loading plot from multivariate data analysis revealed that CH and CO infrared signals from terpenoids in the extract were positively correlated with the α-glucosidase inhibitory activity. The developed partial least square model was validated through a testing on the external samples. The result concludes that the developed model is valid and capable of predicting α-glucosidase inhibitory activity of the external samples. Elsevier B.V. 2019-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/49730/1/49730_Rapid%20investigation%20of%20%CE%B1-glucosidase.pdf application/pdf en http://irep.iium.edu.my/49730/2/49730_Rapid%20investigation%20of%20%CE%B1-glucosidase_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/49730/3/49730_Rapid%20investigation%20of%20%CE%B1-glucosidase_WOS.pdf Murugesu, Suganya and Ahmed, Qamar Uddin and Uzir, Bisha Fathamah and Nik Yusof, Nik Idris and Perumal, Vikneswari and Ibrahim, Zalikha and Abas, Faridah and Shaari, Khozirah and Khatib, Alfi (2019) Rapid investigation of α-glucosidase inhibitory activity of Clinacanthus nutans leaf using infrared fingerprinting. Vibrational Spectroscopy, 100. pp. 22-29. ISSN 0924-2031 E-ISSN 1873-3697 https://www.sciencedirect.com/science/article/pii/S0924203118300626 10.1016/j.vibspec.2018.10.007
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle	RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry Murugesu, Suganya Ahmed, Qamar Uddin Uzir, Bisha Fathamah Nik Yusof, Nik Idris Perumal, Vikneswari Ibrahim, Zalikha Abas, Faridah Shaari, Khozirah Khatib, Alfi Rapid investigation of α-glucosidase inhibitory activity of Clinacanthus nutans leaf using infrared fingerprinting
description	The analytical method used in the quality control of Clinacanthus nutans leaves has not been well developed. Therefore, this study aimed to develop a simple analytical method to predict α-glucosidase inhibitory activity of this herb based on its infrared fingerprinting. The dried extracts obtained from maceration using solvents with different polarities were evaluated for the α-glucosidase inhibitory activity and analysed through infrared spectroscopy. Multivariate data analysis was performed by correlating the bioactivity and infrared spectrum of each extract using partial least square method. The loading plot from multivariate data analysis revealed that CH and CO infrared signals from terpenoids in the extract were positively correlated with the α-glucosidase inhibitory activity. The developed partial least square model was validated through a testing on the external samples. The result concludes that the developed model is valid and capable of predicting α-glucosidase inhibitory activity of the external samples.
format	Article
author	Murugesu, Suganya Ahmed, Qamar Uddin Uzir, Bisha Fathamah Nik Yusof, Nik Idris Perumal, Vikneswari Ibrahim, Zalikha Abas, Faridah Shaari, Khozirah Khatib, Alfi
author_facet	Murugesu, Suganya Ahmed, Qamar Uddin Uzir, Bisha Fathamah Nik Yusof, Nik Idris Perumal, Vikneswari Ibrahim, Zalikha Abas, Faridah Shaari, Khozirah Khatib, Alfi
author_sort	Murugesu, Suganya
title	Rapid investigation of α-glucosidase inhibitory activity of Clinacanthus nutans leaf using infrared fingerprinting
title_short	Rapid investigation of α-glucosidase inhibitory activity of Clinacanthus nutans leaf using infrared fingerprinting
title_full	Rapid investigation of α-glucosidase inhibitory activity of Clinacanthus nutans leaf using infrared fingerprinting
title_fullStr	Rapid investigation of α-glucosidase inhibitory activity of Clinacanthus nutans leaf using infrared fingerprinting
title_full_unstemmed	Rapid investigation of α-glucosidase inhibitory activity of Clinacanthus nutans leaf using infrared fingerprinting
title_sort	rapid investigation of α-glucosidase inhibitory activity of clinacanthus nutans leaf using infrared fingerprinting
publisher	Elsevier B.V.
publishDate	2019
url	http://irep.iium.edu.my/49730/ http://irep.iium.edu.my/49730/ http://irep.iium.edu.my/49730/ http://irep.iium.edu.my/49730/1/49730_Rapid%20investigation%20of%20%CE%B1-glucosidase.pdf http://irep.iium.edu.my/49730/2/49730_Rapid%20investigation%20of%20%CE%B1-glucosidase_SCOPUS.pdf http://irep.iium.edu.my/49730/3/49730_Rapid%20investigation%20of%20%CE%B1-glucosidase_WOS.pdf
first_indexed	2023-09-18T21:10:17Z
last_indexed	2023-09-18T21:10:17Z
_version_	1777411206424821760

Rapid investigation of α-glucosidase inhibitory activity of Clinacanthus nutans leaf using infrared fingerprinting

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