Screening for thalassaemia among group of students of a higher institution – our experience

Introduction: Thalassaemia is an inherited blood disorder and is a significant public health alarm in Malaysia with many not knowing they are carriers of this haemoglobin disorders. Materials and methods: This study conducted a one off collection of blood samples from 72 Malays students of Interna...

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Main Authors:	A.Talib, Norlelawati, Muhammad, Hadijah, Hadzir, Siti Nor Haiza, I, Rusmawati, MS, Salman, Jantan, Abdul Wahab, Muhammad, Siti Aesah @ Naznin
Format:	Article
Language:	English
Published:	Faculty of Medicine, International Islamic University Malaysia 2011
Subjects:	RB Pathology
Online Access:	http://irep.iium.edu.my/4959/ http://irep.iium.edu.my/4959/ http://irep.iium.edu.my/4959/1/Thal_screening%2C2011.pdf

id	iium-4959
recordtype	eprints
spelling	iium-49592012-02-17T03:39:29Z http://irep.iium.edu.my/4959/ Screening for thalassaemia among group of students of a higher institution – our experience A.Talib, Norlelawati Muhammad, Hadijah Hadzir, Siti Nor Haiza I, Rusmawati MS, Salman Jantan, Abdul Wahab Muhammad, Siti Aesah @ Naznin RB Pathology Introduction: Thalassaemia is an inherited blood disorder and is a significant public health alarm in Malaysia with many not knowing they are carriers of this haemoglobin disorders. Materials and methods: This study conducted a one off collection of blood samples from 72 Malays students of International Islamic University Malaysia (IIUM) in Kuantan. Blood samples were subjected to conventional haemoglobin analyses that include full blood count and picture, HPLC, Haemoglobin electrophoresis and H-inclusion test. All samples were also genotyped for alpha thalassaemia–1 of Southeast Asia (a-Thal1SEA). Result: There were 17(23.6%) students who were diagnosed as thalassaemia carriers. Out of this, four (5.5 %) and six (8.3 %) students were presumptive β-thalassaemia trait and Haemoglobin-E trait as determined by the HPLC assay respectively. Nine (12.5%) students were genotyped a-Thal1SEA among whom two were also β-thalassaemia carriers. All thalassaemia cases had MCH of < 27pg. Nonetheless, two out of six Haemoglobin-E trait and three out of nine a-Thal1SEA carrier had MCV value of >80fL. Two out of four (50%) presumptive β -thalassaemia trait and one out of six (17%) students of presumptive Haemoglobin-E trait had family history of thalassaemia respectively. Conclusion: The high occurrence of the three common types of thalassaemia carrier (β, Hb-E and a-Thal1SEA thalassaemia) in our small group of subjects could be due to better participation of students who had family history of thalassaemia. The study reaffirmed the importance of molecular study for detection of alpha-thalassaemia and the use of MCH value of <27pg rather than MCV value of < 80fL for prediction of thalassaemia. KEYWORDS: Thalassaemia, screening, diagnosis, genetic carriers. Faculty of Medicine, International Islamic University Malaysia 2011-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/4959/1/Thal_screening%2C2011.pdf A.Talib, Norlelawati and Muhammad, Hadijah and Hadzir, Siti Nor Haiza and I, Rusmawati and MS, Salman and Jantan, Abdul Wahab and Muhammad, Siti Aesah @ Naznin (2011) Screening for thalassaemia among group of students of a higher institution – our experience. International Medical Journal Malaysia, 10 (1). pp. 3-6. ISSN 1823-4631 http://www.e-imj.com/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RB Pathology
spellingShingle	RB Pathology A.Talib, Norlelawati Muhammad, Hadijah Hadzir, Siti Nor Haiza I, Rusmawati MS, Salman Jantan, Abdul Wahab Muhammad, Siti Aesah @ Naznin Screening for thalassaemia among group of students of a higher institution – our experience
description	Introduction: Thalassaemia is an inherited blood disorder and is a significant public health alarm in Malaysia with many not knowing they are carriers of this haemoglobin disorders. Materials and methods: This study conducted a one off collection of blood samples from 72 Malays students of International Islamic University Malaysia (IIUM) in Kuantan. Blood samples were subjected to conventional haemoglobin analyses that include full blood count and picture, HPLC, Haemoglobin electrophoresis and H-inclusion test. All samples were also genotyped for alpha thalassaemia–1 of Southeast Asia (a-Thal1SEA). Result: There were 17(23.6%) students who were diagnosed as thalassaemia carriers. Out of this, four (5.5 %) and six (8.3 %) students were presumptive β-thalassaemia trait and Haemoglobin-E trait as determined by the HPLC assay respectively. Nine (12.5%) students were genotyped a-Thal1SEA among whom two were also β-thalassaemia carriers. All thalassaemia cases had MCH of < 27pg. Nonetheless, two out of six Haemoglobin-E trait and three out of nine a-Thal1SEA carrier had MCV value of >80fL. Two out of four (50%) presumptive β -thalassaemia trait and one out of six (17%) students of presumptive Haemoglobin-E trait had family history of thalassaemia respectively. Conclusion: The high occurrence of the three common types of thalassaemia carrier (β, Hb-E and a-Thal1SEA thalassaemia) in our small group of subjects could be due to better participation of students who had family history of thalassaemia. The study reaffirmed the importance of molecular study for detection of alpha-thalassaemia and the use of MCH value of <27pg rather than MCV value of < 80fL for prediction of thalassaemia. KEYWORDS: Thalassaemia, screening, diagnosis, genetic carriers.
format	Article
author	A.Talib, Norlelawati Muhammad, Hadijah Hadzir, Siti Nor Haiza I, Rusmawati MS, Salman Jantan, Abdul Wahab Muhammad, Siti Aesah @ Naznin
author_facet	A.Talib, Norlelawati Muhammad, Hadijah Hadzir, Siti Nor Haiza I, Rusmawati MS, Salman Jantan, Abdul Wahab Muhammad, Siti Aesah @ Naznin
author_sort	A.Talib, Norlelawati
title	Screening for thalassaemia among group of students of a higher institution – our experience
title_short	Screening for thalassaemia among group of students of a higher institution – our experience
title_full	Screening for thalassaemia among group of students of a higher institution – our experience
title_fullStr	Screening for thalassaemia among group of students of a higher institution – our experience
title_full_unstemmed	Screening for thalassaemia among group of students of a higher institution – our experience
title_sort	screening for thalassaemia among group of students of a higher institution – our experience
publisher	Faculty of Medicine, International Islamic University Malaysia
publishDate	2011
url	http://irep.iium.edu.my/4959/ http://irep.iium.edu.my/4959/ http://irep.iium.edu.my/4959/1/Thal_screening%2C2011.pdf
first_indexed	2023-09-18T20:13:24Z
last_indexed	2023-09-18T20:13:24Z
_version_	1777407627425218560

Screening for thalassaemia among group of students of a higher institution – our experience

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