Prevalence of thyroid disorders and thyroid autoantibodies among coastal communities of Malaysia (part of nationwide study of thyroid disorders in Malaysia)

Objectives To determine the prevalence of thyroid disorders and thyroid autoantibodies in the coastal communities of Malaysia. This study is part of a nationwide study looking into the prevalence of thyroid disorders. Methods A cross sectional study was performed in two coastal districts of r...

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Main Authors:	Shahar , Mohammad Arif, Ghani, Liyana, Omar , Ahmad Marzuki, Loh , HH, Ooi , CP, MY, Yusniza, H, Zanariah, S, Subashini, Ibrahim, Luqman, Ab Wahab, Norasyikin, Sukor, Norlela, Md Zain, Rabizah, Long , Kha Ching, Mohd Razali, Amyliaton, Zainuddin, Noradilah, Mat, Nurul Hani, Mender, Fadhlin, Muhajir, Musilawati, Othman, Hanita, Kamaruddin, Nor Azmi
Format:	Article
Language:	English English English English English English
Published:	ASEAN Federation of Endocrine Societies 2015
Subjects:	RC Internal medicine
Online Access:	http://irep.iium.edu.my/49157/ http://irep.iium.edu.my/49157/1/DR_ARIF_Poster_AFES_2015.pdf http://irep.iium.edu.my/49157/2/Gmail_-_Your_Poster_Number.pdf http://irep.iium.edu.my/49157/3/Prevalence_of_thyroid_disorders_and_thyroid_autoantibodies_among_coastal_communities_of_Malaysia.pdf http://irep.iium.edu.my/49157/4/winner_afes_2015.pdf http://irep.iium.edu.my/49157/12/prevalence_of_thyroid_disorders.pdf http://irep.iium.edu.my/49157/13/AFES_2015_Abstract_Book_v3_Final.pdf

id	iium-49157
recordtype	eprints
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English English English English
topic	RC Internal medicine
spellingShingle	RC Internal medicine Shahar , Mohammad Arif Ghani, Liyana Omar , Ahmad Marzuki Loh , HH Ooi , CP MY, Yusniza H, Zanariah S, Subashini Ibrahim, Luqman Ab Wahab, Norasyikin Sukor, Norlela Md Zain, Rabizah Long , Kha Ching Mohd Razali, Amyliaton Zainuddin, Noradilah Mat, Nurul Hani Mender, Fadhlin Muhajir, Musilawati Othman, Hanita Kamaruddin, Nor Azmi Prevalence of thyroid disorders and thyroid autoantibodies among coastal communities of Malaysia (part of nationwide study of thyroid disorders in Malaysia)
description	Objectives To determine the prevalence of thyroid disorders and thyroid autoantibodies in the coastal communities of Malaysia. This study is part of a nationwide study looking into the prevalence of thyroid disorders. Methods A cross sectional study was performed in two coastal districts of rural Selangor. A village from each district was chosen where a participant from each household from the village was selected using KISH tables. Sociodemographic data, medical history, anthropometric measurement and thyroid examination were performed. The presence of goiter was recorded according to the World Health Organization (WHO) goiter grading system. Blood withdrawn was tested for thyroid function and thyroid autoantibodies. Thyroid antibodies analyses were done using Immulite 2000 system. Lowest detectable limit for anti-thyroperoxidase (antiTPO) and antithyroglobulin (antiTG) are 10 IU/mL and 20 IU/mL respectively. Low, moderate and high titre is defined 40 - 100 IU/mL, 101-1000 IU/mL and >1000 IU/mL respectively. Results A total of 418 subjects were recruited with a mean age of 54.1 ± 14.2 years. Majority were Malays (86.8%), followed by Indians (11.7%) and Chinese (1.4%). Among respondents, 2.9% had Grade 1 and 8.9% had Grade 2 goitre. A mere 3.4% had clinically palpable thyroid nodules. A total of 411 blood samples were available for thyroid level assessment, with 1.9% of respondents were found to have hypothyroidism while 85.6% had TSH in the range of 0.32-2.5 mIU/L. The prevalence of overt and subclinical hypothyroidism was 0.2% and 1.7% AFES 2015 10 – 13 December 2015 respectively. On the otherhand, 3.4% of respondents were hyperthyroid (TSH < 0.32 mIU/L) with prevalence of overt and subclinical hyperthyroidism being 0.5% and 2.9% respectively. Among 417 samples which were available for antiTPO analysis, 8.9% has detectable antiTPO titre (>40.0 IU/mL), with 4.3% had moderate and 2.4% had high antiTPO titres. One respondent (10%) from among those with high antiTPO titres was found to have T3 thyrotoxicosis. Fourty percent of euthyroid respondents with high titre and 38.9% with moderate titre had high normal TSH, in the range of 2.51 – 5.00 mIU/L (p<0.001). Among 417 samples which are available for antiTG analysis, 3.4% and 5.3% had low detectable and moderate antiTG titres respectively. Only 0.5% (2 respondents) had high antiTG titre (>1000 IU/mL) and found to be hypothyroid. Among those with moderately positive titre, 9.1% were hyperthyroid and majority (63.6%), although euthyroid, had TSH levels between 0.32 – 2.50 mIU/L (p<0.001). Conclusion The low prevalence of thyroid antibodies and thyroid disorders in coastal communities could be attributed to the iodine sufficient status in those areas. Euthyroid respondents with moderate and high antiTPO titres tend to have higher TSH levels, while those with moderate and high antiTG titres had lower TSH levels.
format	Article
author	Shahar , Mohammad Arif Ghani, Liyana Omar , Ahmad Marzuki Loh , HH Ooi , CP MY, Yusniza H, Zanariah S, Subashini Ibrahim, Luqman Ab Wahab, Norasyikin Sukor, Norlela Md Zain, Rabizah Long , Kha Ching Mohd Razali, Amyliaton Zainuddin, Noradilah Mat, Nurul Hani Mender, Fadhlin Muhajir, Musilawati Othman, Hanita Kamaruddin, Nor Azmi
author_facet	Shahar , Mohammad Arif Ghani, Liyana Omar , Ahmad Marzuki Loh , HH Ooi , CP MY, Yusniza H, Zanariah S, Subashini Ibrahim, Luqman Ab Wahab, Norasyikin Sukor, Norlela Md Zain, Rabizah Long , Kha Ching Mohd Razali, Amyliaton Zainuddin, Noradilah Mat, Nurul Hani Mender, Fadhlin Muhajir, Musilawati Othman, Hanita Kamaruddin, Nor Azmi
author_sort	Shahar , Mohammad Arif
title	Prevalence of thyroid disorders and thyroid autoantibodies among coastal communities of Malaysia (part of nationwide study of thyroid disorders in Malaysia)
title_short	Prevalence of thyroid disorders and thyroid autoantibodies among coastal communities of Malaysia (part of nationwide study of thyroid disorders in Malaysia)
title_full	Prevalence of thyroid disorders and thyroid autoantibodies among coastal communities of Malaysia (part of nationwide study of thyroid disorders in Malaysia)
title_fullStr	Prevalence of thyroid disorders and thyroid autoantibodies among coastal communities of Malaysia (part of nationwide study of thyroid disorders in Malaysia)
title_full_unstemmed	Prevalence of thyroid disorders and thyroid autoantibodies among coastal communities of Malaysia (part of nationwide study of thyroid disorders in Malaysia)
title_sort	prevalence of thyroid disorders and thyroid autoantibodies among coastal communities of malaysia (part of nationwide study of thyroid disorders in malaysia)
publisher	ASEAN Federation of Endocrine Societies
publishDate	2015
url	http://irep.iium.edu.my/49157/ http://irep.iium.edu.my/49157/1/DR_ARIF_Poster_AFES_2015.pdf http://irep.iium.edu.my/49157/2/Gmail_-_Your_Poster_Number.pdf http://irep.iium.edu.my/49157/3/Prevalence_of_thyroid_disorders_and_thyroid_autoantibodies_among_coastal_communities_of_Malaysia.pdf http://irep.iium.edu.my/49157/4/winner_afes_2015.pdf http://irep.iium.edu.my/49157/12/prevalence_of_thyroid_disorders.pdf http://irep.iium.edu.my/49157/13/AFES_2015_Abstract_Book_v3_Final.pdf
first_indexed	2023-09-18T21:09:32Z
last_indexed	2023-09-18T21:09:32Z
_version_	1777411160024285184
spelling	iium-491572018-05-22T01:57:44Z http://irep.iium.edu.my/49157/ Prevalence of thyroid disorders and thyroid autoantibodies among coastal communities of Malaysia (part of nationwide study of thyroid disorders in Malaysia) Shahar , Mohammad Arif Ghani, Liyana Omar , Ahmad Marzuki Loh , HH Ooi , CP MY, Yusniza H, Zanariah S, Subashini Ibrahim, Luqman Ab Wahab, Norasyikin Sukor, Norlela Md Zain, Rabizah Long , Kha Ching Mohd Razali, Amyliaton Zainuddin, Noradilah Mat, Nurul Hani Mender, Fadhlin Muhajir, Musilawati Othman, Hanita Kamaruddin, Nor Azmi RC Internal medicine Objectives To determine the prevalence of thyroid disorders and thyroid autoantibodies in the coastal communities of Malaysia. This study is part of a nationwide study looking into the prevalence of thyroid disorders. Methods A cross sectional study was performed in two coastal districts of rural Selangor. A village from each district was chosen where a participant from each household from the village was selected using KISH tables. Sociodemographic data, medical history, anthropometric measurement and thyroid examination were performed. The presence of goiter was recorded according to the World Health Organization (WHO) goiter grading system. Blood withdrawn was tested for thyroid function and thyroid autoantibodies. Thyroid antibodies analyses were done using Immulite 2000 system. Lowest detectable limit for anti-thyroperoxidase (antiTPO) and antithyroglobulin (antiTG) are 10 IU/mL and 20 IU/mL respectively. Low, moderate and high titre is defined 40 - 100 IU/mL, 101-1000 IU/mL and >1000 IU/mL respectively. Results A total of 418 subjects were recruited with a mean age of 54.1 ± 14.2 years. Majority were Malays (86.8%), followed by Indians (11.7%) and Chinese (1.4%). Among respondents, 2.9% had Grade 1 and 8.9% had Grade 2 goitre. A mere 3.4% had clinically palpable thyroid nodules. A total of 411 blood samples were available for thyroid level assessment, with 1.9% of respondents were found to have hypothyroidism while 85.6% had TSH in the range of 0.32-2.5 mIU/L. The prevalence of overt and subclinical hypothyroidism was 0.2% and 1.7% AFES 2015 10 – 13 December 2015 respectively. On the otherhand, 3.4% of respondents were hyperthyroid (TSH < 0.32 mIU/L) with prevalence of overt and subclinical hyperthyroidism being 0.5% and 2.9% respectively. Among 417 samples which were available for antiTPO analysis, 8.9% has detectable antiTPO titre (>40.0 IU/mL), with 4.3% had moderate and 2.4% had high antiTPO titres. One respondent (10%) from among those with high antiTPO titres was found to have T3 thyrotoxicosis. Fourty percent of euthyroid respondents with high titre and 38.9% with moderate titre had high normal TSH, in the range of 2.51 – 5.00 mIU/L (p<0.001). Among 417 samples which are available for antiTG analysis, 3.4% and 5.3% had low detectable and moderate antiTG titres respectively. Only 0.5% (2 respondents) had high antiTG titre (>1000 IU/mL) and found to be hypothyroid. Among those with moderately positive titre, 9.1% were hyperthyroid and majority (63.6%), although euthyroid, had TSH levels between 0.32 – 2.50 mIU/L (p<0.001). Conclusion The low prevalence of thyroid antibodies and thyroid disorders in coastal communities could be attributed to the iodine sufficient status in those areas. Euthyroid respondents with moderate and high antiTPO titres tend to have higher TSH levels, while those with moderate and high antiTG titres had lower TSH levels. ASEAN Federation of Endocrine Societies 2015 Article PeerReviewed application/pdf en http://irep.iium.edu.my/49157/1/DR_ARIF_Poster_AFES_2015.pdf application/pdf en http://irep.iium.edu.my/49157/2/Gmail_-_Your_Poster_Number.pdf application/pdf en http://irep.iium.edu.my/49157/3/Prevalence_of_thyroid_disorders_and_thyroid_autoantibodies_among_coastal_communities_of_Malaysia.pdf application/pdf en http://irep.iium.edu.my/49157/4/winner_afes_2015.pdf application/pdf en http://irep.iium.edu.my/49157/12/prevalence_of_thyroid_disorders.pdf application/pdf en http://irep.iium.edu.my/49157/13/AFES_2015_Abstract_Book_v3_Final.pdf Shahar , Mohammad Arif and Ghani, Liyana and Omar , Ahmad Marzuki and Loh , HH and Ooi , CP and MY, Yusniza and H, Zanariah and S, Subashini and Ibrahim, Luqman and Ab Wahab, Norasyikin and Sukor, Norlela and Md Zain, Rabizah and Long , Kha Ching and Mohd Razali, Amyliaton and Zainuddin, Noradilah and Mat, Nurul Hani and Mender, Fadhlin and Muhajir, Musilawati and Othman, Hanita and Kamaruddin, Nor Azmi (2015) Prevalence of thyroid disorders and thyroid autoantibodies among coastal communities of Malaysia (part of nationwide study of thyroid disorders in Malaysia). Journal of the ASEAN Federation of Endocrine Societies, 30 (2). p. 220. ISSN 0857-1074 (print) 2308-118X (online)

Prevalence of thyroid disorders and thyroid autoantibodies among coastal communities of Malaysia (part of nationwide study of thyroid disorders in Malaysia)

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