Synthesis, spectroscopic studies and antibacterial activity of new lauroyl thiourea amino acid derivatives
Four new thiourea compounds have been successfully synthesized and characterized from combination of lauroyl chloride, ammonium thiocyanate and simple amino acids in acetone. The structure of the respective compounds, namely 3-(3-dodecanoyl-thioureido)propionic acid (R1), 2-(3-dodecanoyl-thioureido)...
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India
2016
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| Online Access: | http://irep.iium.edu.my/49124/ http://irep.iium.edu.my/49124/ http://irep.iium.edu.my/49124/ http://irep.iium.edu.my/49124/1/027-19430_%28596-600%29-2.pdf http://irep.iium.edu.my/49124/4/49124_Synthesis%2C_spectroscopic_studies_and_antibacterial_activity_SCOPUS.pdf |
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iium-491242017-01-04T00:37:46Z http://irep.iium.edu.my/49124/ Synthesis, spectroscopic studies and antibacterial activity of new lauroyl thiourea amino acid derivatives Abdul Kadir, Maisara Ramli, Rozana Mohd Yusof , Mohd Sukeri Ismail, Naemah Ngah, Nurziana QD Chemistry Four new thiourea compounds have been successfully synthesized and characterized from combination of lauroyl chloride, ammonium thiocyanate and simple amino acids in acetone. The structure of the respective compounds, namely 3-(3-dodecanoyl-thioureido)propionic acid (R1), 2-(3-dodecanoyl-thioureido)-3-methyl butyric acid (R2), (3-dodecanoyl-thioureido)acetic acid (R3) and 2-(3-dodecanoyl- thioureido)-3-phenyl propionic acid (R4) are confirmed by combination of spectroscopic techniques such as infrared, ultraviolet and nuclear magnetic resonance. The antibacterial activity of these compounds are investigated towards selected bacteria and the results show that compound R4 displays better antibacterial activity compared to R1-R3 and as well as to few reported compounds. Compound R4 shows good antibacterial activity towards two Gram-negative bacteria Escherichia coli and Salmonella typhimurium, with inhibition zone approximately 8 mm wide and minimum inhibitory concentration (MIC) 50 μg/mL, respectively. The good results given by R4 might be attributed by the presence of alkyl and phenyl group that increases the lipophilicity and stability of the compounds. India 2016 Article PeerReviewed application/pdf en http://irep.iium.edu.my/49124/1/027-19430_%28596-600%29-2.pdf application/pdf en http://irep.iium.edu.my/49124/4/49124_Synthesis%2C_spectroscopic_studies_and_antibacterial_activity_SCOPUS.pdf Abdul Kadir, Maisara and Ramli, Rozana and Mohd Yusof , Mohd Sukeri and Ismail, Naemah and Ngah, Nurziana (2016) Synthesis, spectroscopic studies and antibacterial activity of new lauroyl thiourea amino acid derivatives. Asian Journal of Chemistry, 28 (3). pp. 596-600. ISSN 0970-7077 E-ISSN 0975-427X http://www.asianjournalofchemistry.co.in/user/journal/viewarticle.aspx?ArticleID=28_3_27 10.14233/ajchem.2016.19430 |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English English |
| topic |
QD Chemistry |
| spellingShingle |
QD Chemistry Abdul Kadir, Maisara Ramli, Rozana Mohd Yusof , Mohd Sukeri Ismail, Naemah Ngah, Nurziana Synthesis, spectroscopic studies and antibacterial activity of new lauroyl thiourea amino acid derivatives |
| description |
Four new thiourea compounds have been successfully synthesized and characterized from combination of lauroyl chloride, ammonium thiocyanate and simple amino acids in acetone. The structure of the respective compounds, namely 3-(3-dodecanoyl-thioureido)propionic acid (R1), 2-(3-dodecanoyl-thioureido)-3-methyl butyric acid (R2), (3-dodecanoyl-thioureido)acetic acid (R3) and 2-(3-dodecanoyl- thioureido)-3-phenyl propionic acid (R4) are confirmed by combination of spectroscopic techniques such as infrared, ultraviolet and nuclear magnetic resonance. The antibacterial activity of these compounds are investigated towards selected bacteria and the results show that compound R4 displays better antibacterial activity compared to R1-R3 and as well as to few reported compounds. Compound R4 shows good antibacterial activity towards two Gram-negative bacteria Escherichia coli and Salmonella typhimurium, with inhibition zone approximately 8 mm wide and minimum inhibitory concentration (MIC) 50 μg/mL, respectively. The good results given by R4 might be attributed by the presence of alkyl and phenyl group that increases the lipophilicity and stability of the compounds. |
| format |
Article |
| author |
Abdul Kadir, Maisara Ramli, Rozana Mohd Yusof , Mohd Sukeri Ismail, Naemah Ngah, Nurziana |
| author_facet |
Abdul Kadir, Maisara Ramli, Rozana Mohd Yusof , Mohd Sukeri Ismail, Naemah Ngah, Nurziana |
| author_sort |
Abdul Kadir, Maisara |
| title |
Synthesis, spectroscopic studies and antibacterial activity of new lauroyl thiourea amino acid derivatives |
| title_short |
Synthesis, spectroscopic studies and antibacterial activity of new lauroyl thiourea amino acid derivatives |
| title_full |
Synthesis, spectroscopic studies and antibacterial activity of new lauroyl thiourea amino acid derivatives |
| title_fullStr |
Synthesis, spectroscopic studies and antibacterial activity of new lauroyl thiourea amino acid derivatives |
| title_full_unstemmed |
Synthesis, spectroscopic studies and antibacterial activity of new lauroyl thiourea amino acid derivatives |
| title_sort |
synthesis, spectroscopic studies and antibacterial activity of new lauroyl thiourea amino acid derivatives |
| publisher |
India |
| publishDate |
2016 |
| url |
http://irep.iium.edu.my/49124/ http://irep.iium.edu.my/49124/ http://irep.iium.edu.my/49124/ http://irep.iium.edu.my/49124/1/027-19430_%28596-600%29-2.pdf http://irep.iium.edu.my/49124/4/49124_Synthesis%2C_spectroscopic_studies_and_antibacterial_activity_SCOPUS.pdf |
| first_indexed |
2023-09-18T21:09:29Z |
| last_indexed |
2023-09-18T21:09:29Z |
| _version_ |
1777411156805156864 |