Microstructural white matter changes mediated age- related cognitive decline in the Montreal Cognitive Assessment (MoCA)

Although the relationship between aging and cognitive decline is well established, there is substantial individual variability in the degree of cognitive decline in older adults. The present study investigates whether variability in cognitive performance in community-dwelling older adults is related...

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Main Authors:	Jolly, Todd, Cooper, Patrick, Wan Ahmadul Badwi, Syarifah Azizah, Phillips, Natalie, Rennie, Jaime, Levi, Christopher, Drysdale, Karen, Parsons, Mark, Michie, Patricia, Karayanidis, Frini
Format:	Article
Language:	English English
Published:	Wiley Blackwell 2016
Subjects:	QP Physiology
Online Access:	http://irep.iium.edu.my/48900/ http://irep.iium.edu.my/48900/ http://irep.iium.edu.my/48900/ http://irep.iium.edu.my/48900/1/Microstructural_white_matter_changes_mediate_age%26%238208_related_cognitive_decline_on_the_Montreal_Cognitive_Assessment_%28MoCA%29.pdf http://irep.iium.edu.my/48900/4/48900.pdf

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spelling	iium-489002017-07-20T07:38:57Z http://irep.iium.edu.my/48900/ Microstructural white matter changes mediated age- related cognitive decline in the Montreal Cognitive Assessment (MoCA) Jolly, Todd Cooper, Patrick Wan Ahmadul Badwi, Syarifah Azizah Phillips, Natalie Rennie, Jaime Levi, Christopher Drysdale, Karen Parsons, Mark Michie, Patricia Karayanidis, Frini QP Physiology Although the relationship between aging and cognitive decline is well established, there is substantial individual variability in the degree of cognitive decline in older adults. The present study investigates whether variability in cognitive performance in community-dwelling older adults is related to the presence of whole brain or tract-specific changes in white matter microstructure. Specifically, we examine whether age-related decline in performance on the Montreal Cognitive Assessment (MoCA), a cognitive screening tool, is mediated by the white matter microstructural decline. We also examine if this relationship is driven by the presence of cardiovascular risk factors or variability in cerebral arterial pulsatility, an index of cardiovascular risk. Sixty-nine participants (aged 43–87) completed behavioral and MRI testing including T1 structural, T2-weighted FLAIR, and diffusion-weighted imaging (DWI) sequences. Measures of white matter microstructure were calculated using diffusion tensor imaging analyses on the DWI sequence. Multiple linear regression revealed that MoCA scores were predicted by radial diffusivity (RaD) of white matter beyond age or other cerebral measures. While increasing age and arterial pulsatility were associated with increasing RaD, these factors did not mediate the relationship between total white matter RaD and MoCA. Further, the relationship between MoCA and RaD was specific to participants who reported at least one cardiovascular risk factor. These findings highlight the importance of cardiovascular risk factors in the presentation of cognitive decline in old age. Further work is needed to establish whether medical or lifestyle management of these risk factors can prevent or reverse cognitive decline in old age. Wiley Blackwell 2016-02-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/48900/1/Microstructural_white_matter_changes_mediate_age%26%238208_related_cognitive_decline_on_the_Montreal_Cognitive_Assessment_%28MoCA%29.pdf application/pdf en http://irep.iium.edu.my/48900/4/48900.pdf Jolly, Todd and Cooper, Patrick and Wan Ahmadul Badwi, Syarifah Azizah and Phillips, Natalie and Rennie, Jaime and Levi, Christopher and Drysdale, Karen and Parsons, Mark and Michie, Patricia and Karayanidis, Frini (2016) Microstructural white matter changes mediated age- related cognitive decline in the Montreal Cognitive Assessment (MoCA). Psychophysiology, 53 (2). pp. 258-267. ISSN 0048-5772 E-ISSN 1469-8986 http://onlinelibrary.wiley.com/doi/10.1111/psyp.12565/pdf DOI: 10.1111/psyp.12565
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QP Physiology
spellingShingle	QP Physiology Jolly, Todd Cooper, Patrick Wan Ahmadul Badwi, Syarifah Azizah Phillips, Natalie Rennie, Jaime Levi, Christopher Drysdale, Karen Parsons, Mark Michie, Patricia Karayanidis, Frini Microstructural white matter changes mediated age- related cognitive decline in the Montreal Cognitive Assessment (MoCA)
description	Although the relationship between aging and cognitive decline is well established, there is substantial individual variability in the degree of cognitive decline in older adults. The present study investigates whether variability in cognitive performance in community-dwelling older adults is related to the presence of whole brain or tract-specific changes in white matter microstructure. Specifically, we examine whether age-related decline in performance on the Montreal Cognitive Assessment (MoCA), a cognitive screening tool, is mediated by the white matter microstructural decline. We also examine if this relationship is driven by the presence of cardiovascular risk factors or variability in cerebral arterial pulsatility, an index of cardiovascular risk. Sixty-nine participants (aged 43–87) completed behavioral and MRI testing including T1 structural, T2-weighted FLAIR, and diffusion-weighted imaging (DWI) sequences. Measures of white matter microstructure were calculated using diffusion tensor imaging analyses on the DWI sequence. Multiple linear regression revealed that MoCA scores were predicted by radial diffusivity (RaD) of white matter beyond age or other cerebral measures. While increasing age and arterial pulsatility were associated with increasing RaD, these factors did not mediate the relationship between total white matter RaD and MoCA. Further, the relationship between MoCA and RaD was specific to participants who reported at least one cardiovascular risk factor. These findings highlight the importance of cardiovascular risk factors in the presentation of cognitive decline in old age. Further work is needed to establish whether medical or lifestyle management of these risk factors can prevent or reverse cognitive decline in old age.
format	Article
author	Jolly, Todd Cooper, Patrick Wan Ahmadul Badwi, Syarifah Azizah Phillips, Natalie Rennie, Jaime Levi, Christopher Drysdale, Karen Parsons, Mark Michie, Patricia Karayanidis, Frini
author_facet	Jolly, Todd Cooper, Patrick Wan Ahmadul Badwi, Syarifah Azizah Phillips, Natalie Rennie, Jaime Levi, Christopher Drysdale, Karen Parsons, Mark Michie, Patricia Karayanidis, Frini
author_sort	Jolly, Todd
title	Microstructural white matter changes mediated age- related cognitive decline in the Montreal Cognitive Assessment (MoCA)
title_short	Microstructural white matter changes mediated age- related cognitive decline in the Montreal Cognitive Assessment (MoCA)
title_full	Microstructural white matter changes mediated age- related cognitive decline in the Montreal Cognitive Assessment (MoCA)
title_fullStr	Microstructural white matter changes mediated age- related cognitive decline in the Montreal Cognitive Assessment (MoCA)
title_full_unstemmed	Microstructural white matter changes mediated age- related cognitive decline in the Montreal Cognitive Assessment (MoCA)
title_sort	microstructural white matter changes mediated age- related cognitive decline in the montreal cognitive assessment (moca)
publisher	Wiley Blackwell
publishDate	2016
url	http://irep.iium.edu.my/48900/ http://irep.iium.edu.my/48900/ http://irep.iium.edu.my/48900/ http://irep.iium.edu.my/48900/1/Microstructural_white_matter_changes_mediate_age%26%238208_related_cognitive_decline_on_the_Montreal_Cognitive_Assessment_%28MoCA%29.pdf http://irep.iium.edu.my/48900/4/48900.pdf
first_indexed	2023-09-18T21:09:15Z
last_indexed	2023-09-18T21:09:15Z
_version_	1777411141619679232

Microstructural white matter changes mediated age- related cognitive decline in the Montreal Cognitive Assessment (MoCA)

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