Solubility prediction of L-ascorbic acid by using COSMO-RS

Pharmaceutical is a highly regulated industry based on its nature that involves human life. Every decision must be scientifically sound from the early stage in order to provide security and safety to the patient. Only 1 from 4000 synthesized drugs reach the market which cost about $800-900 million d...

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Main Authors:	Hassan, Syajaratul Jahriah, Adam, Fatmawati, Abu Bakar, Mohd Rushdi
Format:	Conference or Workshop Item
Language:	English
Published:	2014
Subjects:	RS192 Materia Medica-Pharmaceutical Technology TP155 Chemical engineering
Online Access:	http://irep.iium.edu.my/48664/ http://irep.iium.edu.my/48664/1/48664_International%20Conference%20in%20Industrial%20Pharmacy%202014.pdf

id	iium-48664
recordtype	eprints
spelling	iium-486642019-10-09T08:23:23Z http://irep.iium.edu.my/48664/ Solubility prediction of L-ascorbic acid by using COSMO-RS Hassan, Syajaratul Jahriah Adam, Fatmawati Abu Bakar, Mohd Rushdi RS192 Materia Medica-Pharmaceutical Technology TP155 Chemical engineering Pharmaceutical is a highly regulated industry based on its nature that involves human life. Every decision must be scientifically sound from the early stage in order to provide security and safety to the patient. Only 1 from 4000 synthesized drugs reach the market which cost about $800-900 million dollar within 8-12 years from discovery to market. Any method that could expedite the research development is highly needed to reduce the development time of newly designed drugs. COSMO-RS is a fast and efficient methodology for predicting the thermodynamic properties of fluids and liquid mixtures that use a statistical thermodynamics approach based on the results of quantum chemical methods (QM) (Klamt & Eckert, 2000). It is programmed based on interacting molecular surface charges. By using COSMO-RS, only melting point and heat of fusion Δh is needed to determine the long and crucial solubility test in any solvent. 2014-08 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/48664/1/48664_International%20Conference%20in%20Industrial%20Pharmacy%202014.pdf Hassan, Syajaratul Jahriah and Adam, Fatmawati and Abu Bakar, Mohd Rushdi (2014) Solubility prediction of L-ascorbic acid by using COSMO-RS. In: International Conference in Industrial Pharmacy 2014, 16th-17th August 2014, Swiss Garden Resort and Spa, Kuantan, Pahang. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS192 Materia Medica-Pharmaceutical Technology TP155 Chemical engineering
spellingShingle	RS192 Materia Medica-Pharmaceutical Technology TP155 Chemical engineering Hassan, Syajaratul Jahriah Adam, Fatmawati Abu Bakar, Mohd Rushdi Solubility prediction of L-ascorbic acid by using COSMO-RS
description	Pharmaceutical is a highly regulated industry based on its nature that involves human life. Every decision must be scientifically sound from the early stage in order to provide security and safety to the patient. Only 1 from 4000 synthesized drugs reach the market which cost about $800-900 million dollar within 8-12 years from discovery to market. Any method that could expedite the research development is highly needed to reduce the development time of newly designed drugs. COSMO-RS is a fast and efficient methodology for predicting the thermodynamic properties of fluids and liquid mixtures that use a statistical thermodynamics approach based on the results of quantum chemical methods (QM) (Klamt & Eckert, 2000). It is programmed based on interacting molecular surface charges. By using COSMO-RS, only melting point and heat of fusion Δh is needed to determine the long and crucial solubility test in any solvent.
format	Conference or Workshop Item
author	Hassan, Syajaratul Jahriah Adam, Fatmawati Abu Bakar, Mohd Rushdi
author_facet	Hassan, Syajaratul Jahriah Adam, Fatmawati Abu Bakar, Mohd Rushdi
author_sort	Hassan, Syajaratul Jahriah
title	Solubility prediction of L-ascorbic acid by using COSMO-RS
title_short	Solubility prediction of L-ascorbic acid by using COSMO-RS
title_full	Solubility prediction of L-ascorbic acid by using COSMO-RS
title_fullStr	Solubility prediction of L-ascorbic acid by using COSMO-RS
title_full_unstemmed	Solubility prediction of L-ascorbic acid by using COSMO-RS
title_sort	solubility prediction of l-ascorbic acid by using cosmo-rs
publishDate	2014
url	http://irep.iium.edu.my/48664/ http://irep.iium.edu.my/48664/1/48664_International%20Conference%20in%20Industrial%20Pharmacy%202014.pdf
first_indexed	2023-09-18T21:08:58Z
last_indexed	2023-09-18T21:08:58Z
_version_	1777411124023525376

Solubility prediction of L-ascorbic acid by using COSMO-RS

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