A cross sectional study of cardiopulmonary complications and severity of pulmonary hypertension and lung fibrosis in patients with systemic sclerosis
Objectives: This study aims to identify the characteristics of scleroderma patients in terms of sociodemographic and clinical characteristics and severity of lung fibrosis and pulmonary hypertension and to show the association between European Scleroderma Study Group (EScSG) scoring and severity of...
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Turkish League Against Rheumatism
2015
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| Online Access: | http://irep.iium.edu.my/48264/ http://irep.iium.edu.my/48264/ http://irep.iium.edu.my/48264/ http://irep.iium.edu.my/48264/1/2015-30-4-311-318-eng.pdf |
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iium-482642018-02-07T07:10:32Z http://irep.iium.edu.my/48264/ A cross sectional study of cardiopulmonary complications and severity of pulmonary hypertension and lung fibrosis in patients with systemic sclerosis Wan Ali, Wan Ahmad Syahril Rozli Mohamed Said, Mohd Shahrir Shaharir , Syahrul Sazliyana Ban , Andrea Yu Lin Hussain, Rizuana Iqbal Rosman, Azmillah R Medicine (General) RC Internal medicine Objectives: This study aims to identify the characteristics of scleroderma patients in terms of sociodemographic and clinical characteristics and severity of lung fibrosis and pulmonary hypertension and to show the association between European Scleroderma Study Group (EScSG) scoring and severity of pulmonary hypertension and lung fibrosis. Patients and methods: This two center cross-sectional study included 43 scleroderma patients (4 males, 39 females; mean age 52 years; range 42 to 59 years) under clinical follow-up. Patients’ sociodemographic data were recorded. Median duration of illness was 10.0 years. All patients underwent blood tests, echocardiogram, full lung function test, six-minute walking test, and high resolution computed tomography of the thorax. Pulmonary hypertension was defined by echocardiogram as systolic pulmonary pressure >36 mmHg. Results: Limited systemic sclerosis was the predominant type (74.7%). Majority of high resolution computed tomography findings showed lung fibrosis with ground glass opacities (74.4%). Pulmonary hypertension was predominantly mild (31.7%), lung function test showed 36.1% restrictive lung disease, and a reduced diffusing capacity of the lungs for carbon monoxide (median 13.85) with reduced six-minute walking test distance (median 300.0 meters). Health Assessment Questionnaire scoring was predominantly in the mild to moderate disability group (median score of 0.5). Five patients (13.9%) had active disease based on the EScSG scoring. There were no significant associations between EScSG scoring and other clinical parameters. Conclusion: In our study, we found that scleroderma was predominant among females and the major type was limited systemic sclerosis. The lung function test revealed a sub-normal diffusing carbon monoxide with a reduced six-minute walking distance. Turkish League Against Rheumatism 2015 Article PeerReviewed application/pdf en http://irep.iium.edu.my/48264/1/2015-30-4-311-318-eng.pdf Wan Ali, Wan Ahmad Syahril Rozli and Mohamed Said, Mohd Shahrir and Shaharir , Syahrul Sazliyana and Ban , Andrea Yu Lin and Hussain, Rizuana Iqbal and Rosman, Azmillah (2015) A cross sectional study of cardiopulmonary complications and severity of pulmonary hypertension and lung fibrosis in patients with systemic sclerosis. Archives of Rheumatology, 30 (4). pp. 311-318. ISSN 2148-5046 http://www.archivesofrheumatology.org/abstract/744 10.5606/ArchRheumatol.2015.5593 |
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Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
R Medicine (General) RC Internal medicine |
| spellingShingle |
R Medicine (General) RC Internal medicine Wan Ali, Wan Ahmad Syahril Rozli Mohamed Said, Mohd Shahrir Shaharir , Syahrul Sazliyana Ban , Andrea Yu Lin Hussain, Rizuana Iqbal Rosman, Azmillah A cross sectional study of cardiopulmonary complications and severity of pulmonary hypertension and lung fibrosis in patients with systemic sclerosis |
| description |
Objectives: This study aims to identify the characteristics of scleroderma patients in terms of sociodemographic and clinical characteristics and
severity of lung fibrosis and pulmonary hypertension and to show the association between European Scleroderma Study Group (EScSG) scoring and severity of pulmonary hypertension and lung fibrosis.
Patients and methods: This two center cross-sectional study included 43 scleroderma patients (4 males, 39 females; mean age 52 years; range 42 to
59 years) under clinical follow-up. Patients’ sociodemographic data were recorded. Median duration of illness was 10.0 years. All patients underwent
blood tests, echocardiogram, full lung function test, six-minute walking test, and high resolution computed tomography of the thorax. Pulmonary
hypertension was defined by echocardiogram as systolic pulmonary pressure >36 mmHg.
Results: Limited systemic sclerosis was the predominant type (74.7%). Majority of high resolution computed tomography findings showed lung
fibrosis with ground glass opacities (74.4%). Pulmonary hypertension was predominantly mild (31.7%), lung function test showed 36.1% restrictive
lung disease, and a reduced diffusing capacity of the lungs for carbon monoxide (median 13.85) with reduced six-minute walking test distance
(median 300.0 meters). Health Assessment Questionnaire scoring was predominantly in the mild to moderate disability group (median score of 0.5).
Five patients (13.9%) had active disease based on the EScSG scoring. There were no significant associations between EScSG scoring and other clinical
parameters.
Conclusion: In our study, we found that scleroderma was predominant among females and the major type was limited systemic sclerosis. The lung
function test revealed a sub-normal diffusing carbon monoxide with a reduced six-minute walking distance. |
| format |
Article |
| author |
Wan Ali, Wan Ahmad Syahril Rozli Mohamed Said, Mohd Shahrir Shaharir , Syahrul Sazliyana Ban , Andrea Yu Lin Hussain, Rizuana Iqbal Rosman, Azmillah |
| author_facet |
Wan Ali, Wan Ahmad Syahril Rozli Mohamed Said, Mohd Shahrir Shaharir , Syahrul Sazliyana Ban , Andrea Yu Lin Hussain, Rizuana Iqbal Rosman, Azmillah |
| author_sort |
Wan Ali, Wan Ahmad Syahril Rozli |
| title |
A cross sectional study of cardiopulmonary complications and severity of pulmonary hypertension and lung fibrosis in patients with systemic sclerosis |
| title_short |
A cross sectional study of cardiopulmonary complications and severity of pulmonary hypertension and lung fibrosis in patients with systemic sclerosis |
| title_full |
A cross sectional study of cardiopulmonary complications and severity of pulmonary hypertension and lung fibrosis in patients with systemic sclerosis |
| title_fullStr |
A cross sectional study of cardiopulmonary complications and severity of pulmonary hypertension and lung fibrosis in patients with systemic sclerosis |
| title_full_unstemmed |
A cross sectional study of cardiopulmonary complications and severity of pulmonary hypertension and lung fibrosis in patients with systemic sclerosis |
| title_sort |
cross sectional study of cardiopulmonary complications and severity of pulmonary hypertension and lung fibrosis in patients with systemic sclerosis |
| publisher |
Turkish League Against Rheumatism |
| publishDate |
2015 |
| url |
http://irep.iium.edu.my/48264/ http://irep.iium.edu.my/48264/ http://irep.iium.edu.my/48264/ http://irep.iium.edu.my/48264/1/2015-30-4-311-318-eng.pdf |
| first_indexed |
2023-09-18T21:08:30Z |
| last_indexed |
2023-09-18T21:08:30Z |
| _version_ |
1777411094303735808 |