Clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia

Objectives: This paper aims to report on a case in which re-challenging with clozapine in combination with lithium in a patient who developed neutropenia was carried out. Methods: The patient was treated with clozapine for treatmentresistant schizophrenia. After five weeks he showed much improvem...

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Main Authors:	Md Rosli, Ahmad Nabil, Subbiah, Rakesh, Maniam, T
Format:	Article
Language:	English
Published:	ASEAN Federation of Psychiatry 2014
Subjects:	R Medicine (General) RC Internal medicine
Online Access:	http://irep.iium.edu.my/47979/ http://irep.iium.edu.my/47979/ http://irep.iium.edu.my/47979/1/CLOZAPINE_RE-CHALLENGE_WITH_LITHIUM.pdf

id	iium-47979
recordtype	eprints
spelling	iium-479792018-06-25T00:24:07Z http://irep.iium.edu.my/47979/ Clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia Md Rosli, Ahmad Nabil Subbiah, Rakesh Maniam, T R Medicine (General) RC Internal medicine Objectives: This paper aims to report on a case in which re-challenging with clozapine in combination with lithium in a patient who developed neutropenia was carried out. Methods: The patient was treated with clozapine for treatmentresistant schizophrenia. After five weeks he showed much improvement but developed neutropenia. Withdrawal of clozapine brought on a relapse of psychotic symptoms. Subsequently, clozapine was reintroduced along with Lithium. The neutrophil count was monitored closely. Results: The neutrophil and white blood cell count were noted to return to normal upon re-challenging, and the patient’s clinical condition also improved. Conclusion: Simultaneous administration of lithium and clozapine to patients experiencing neutropenia on clozapine is a possible strategy. However, very close monitoring of the white count is needed ASEAN Federation of Psychiatry 2014-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/47979/1/CLOZAPINE_RE-CHALLENGE_WITH_LITHIUM.pdf Md Rosli, Ahmad Nabil and Subbiah, Rakesh and Maniam, T (2014) Clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia. ASEAN Journal of Psychiatry, 15 (1). pp. 90-92. ISSN 2231-7791 (O), 1876-2018 (P) http://www.aseanjournalofpsychiatry.org/index.php/aseanjournalofpsychiatry/article/view/191
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General) RC Internal medicine
spellingShingle	R Medicine (General) RC Internal medicine Md Rosli, Ahmad Nabil Subbiah, Rakesh Maniam, T Clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia
description	Objectives: This paper aims to report on a case in which re-challenging with clozapine in combination with lithium in a patient who developed neutropenia was carried out. Methods: The patient was treated with clozapine for treatmentresistant schizophrenia. After five weeks he showed much improvement but developed neutropenia. Withdrawal of clozapine brought on a relapse of psychotic symptoms. Subsequently, clozapine was reintroduced along with Lithium. The neutrophil count was monitored closely. Results: The neutrophil and white blood cell count were noted to return to normal upon re-challenging, and the patient’s clinical condition also improved. Conclusion: Simultaneous administration of lithium and clozapine to patients experiencing neutropenia on clozapine is a possible strategy. However, very close monitoring of the white count is needed
format	Article
author	Md Rosli, Ahmad Nabil Subbiah, Rakesh Maniam, T
author_facet	Md Rosli, Ahmad Nabil Subbiah, Rakesh Maniam, T
author_sort	Md Rosli, Ahmad Nabil
title	Clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia
title_short	Clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia
title_full	Clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia
title_fullStr	Clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia
title_full_unstemmed	Clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia
title_sort	clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia
publisher	ASEAN Federation of Psychiatry
publishDate	2014
url	http://irep.iium.edu.my/47979/ http://irep.iium.edu.my/47979/ http://irep.iium.edu.my/47979/1/CLOZAPINE_RE-CHALLENGE_WITH_LITHIUM.pdf
first_indexed	2023-09-18T21:08:11Z
last_indexed	2023-09-18T21:08:11Z
_version_	1777411074189950976

Clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia

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