Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations

Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations

The epidermal growth factor receptor (EGFR) is the best characterised member of the receptor tyrosine kinases, which play an important role in signalling across mammalian cell membranes. The EGFR juxtamembrane (JM) domain is involved in the mechanism of activation of the receptor, interacting with t...

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Main Authors: Abd Halim, Khairul Bariyyah, Koldsoe, Heidi, Sansom, Mark S.P.
Format: Article
Language:English
Published: Elsevier 2015
Subjects:
QD Chemistry
Online Access:http://irep.iium.edu.my/47685/
http://irep.iium.edu.my/47685/
http://irep.iium.edu.my/47685/
http://irep.iium.edu.my/47685/1/KB_Abd_Halim.pdf
id iium-47685
recordtype eprints
spelling iium-476852017-10-26T07:23:47Z http://irep.iium.edu.my/47685/ Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations Abd Halim, Khairul Bariyyah Koldsoe, Heidi Sansom, Mark S.P. QD Chemistry The epidermal growth factor receptor (EGFR) is the best characterised member of the receptor tyrosine kinases, which play an important role in signalling across mammalian cell membranes. The EGFR juxtamembrane (JM) domain is involved in the mechanism of activation of the receptor, interacting with the anionic lipid phosphatidylinositol 4,5-bisphosphate (PIP2) in the intracellular leaflet of the cell membrane.Multiscale MD simulations were used to characterize PIP2-JM interactions. Simulations of the transmembrane helix plus JM region (TM-JM) dimer (PDB:2M20) in both PIP2-containing and PIP2-depleted lipid bilayer membranes revealed the interactions of the JM with PIP2 and other lipids. Elsevier 2015-05 Article PeerReviewed application/pdf en cc_by http://irep.iium.edu.my/47685/1/KB_Abd_Halim.pdf Abd Halim, Khairul Bariyyah and Koldsoe, Heidi and Sansom, Mark S.P. (2015) Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations. Biochimica et Biophysica Acta, 1850 (5). pp. 1017-1025. ISSN 0304-4165 http://www.ncbi.nlm.nih.gov/pubmed/25219456 doi:10.1016/j.bbagen.2014.09.006
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic QD Chemistry
spellingShingle QD Chemistry
Abd Halim, Khairul Bariyyah
Koldsoe, Heidi
Sansom, Mark S.P.
Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations
description The epidermal growth factor receptor (EGFR) is the best characterised member of the receptor tyrosine kinases, which play an important role in signalling across mammalian cell membranes. The EGFR juxtamembrane (JM) domain is involved in the mechanism of activation of the receptor, interacting with the anionic lipid phosphatidylinositol 4,5-bisphosphate (PIP2) in the intracellular leaflet of the cell membrane.Multiscale MD simulations were used to characterize PIP2-JM interactions. Simulations of the transmembrane helix plus JM region (TM-JM) dimer (PDB:2M20) in both PIP2-containing and PIP2-depleted lipid bilayer membranes revealed the interactions of the JM with PIP2 and other lipids.
format Article
author Abd Halim, Khairul Bariyyah
Koldsoe, Heidi
Sansom, Mark S.P.
author_facet Abd Halim, Khairul Bariyyah
Koldsoe, Heidi
Sansom, Mark S.P.
author_sort Abd Halim, Khairul Bariyyah
title Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations
title_short Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations
title_full Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations
title_fullStr Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations
title_full_unstemmed Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations
title_sort interactions of the egfr juxtamembrane domain with pip2-containing lipid bilayers: insights from multiscale molecular dynamics simulations
publisher Elsevier
publishDate 2015
url http://irep.iium.edu.my/47685/
http://irep.iium.edu.my/47685/
http://irep.iium.edu.my/47685/
http://irep.iium.edu.my/47685/1/KB_Abd_Halim.pdf
first_indexed 2023-09-18T21:07:50Z
last_indexed 2023-09-18T21:07:50Z
_version_ 1777411052040880128

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