Significance of palpitation among hypertensive patients receiving captopril

Captopril prevent the conversion of angiotensin 1 to II by inhibiting of peptidyl dipeptide carboxy hydrolase enzyme. Captopril is an angiotensin converting enzyme (ACE) inhibitors which is the treatment of hypertension. Hundred & eight hypertensive patients taking captoprill as a tablet 25 m...

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Main Authors:	Marbut, Mossa M., K. Rajab, Hassan, Al-Mahmood, Sinan
Format:	Article
Language:	English
Published:	Tikrit University 2009
Subjects:	RM300 Drugs and their action
Online Access:	http://irep.iium.edu.my/47660/ http://irep.iium.edu.my/47660/ http://irep.iium.edu.my/47660/1/Significance_of_palpitation_among_hypertensive_patients_receiving_captopril.pdf

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spelling	iium-476602017-06-20T03:25:17Z http://irep.iium.edu.my/47660/ Significance of palpitation among hypertensive patients receiving captopril Marbut, Mossa M. K. Rajab, Hassan Al-Mahmood, Sinan RM300 Drugs and their action Captopril prevent the conversion of angiotensin 1 to II by inhibiting of peptidyl dipeptide carboxy hydrolase enzyme. Captopril is an angiotensin converting enzyme (ACE) inhibitors which is the treatment of hypertension. Hundred & eight hypertensive patients taking captoprill as a tablet 25 mg twice daily (47 men & 61 women). Each patient had a complete history detailed, physical examination, all patients were interviewed & full medical history was taken. All patients were questioned about the presence or absence of headache, palpitation, cough, flushing, chest pain, dysgeusia & tachycardia. Blood pressure & heart rate were measured for each patient each visit. In hypertensive men, 29 patients out of 47 (61.7%), hypertensive patients are diagnosed as suffering from palpitation. While in hypertensive women, 39 patients out of 61 women have palpitation after taking captopril for 3 months (64%). In regard to serum potassium, it was estimated in 51 hypertensive patients (27 with palpitation & 24 patients without palpitation). There is no significant difference in regarded to serum potassium between hypertensive patients with palpitation & hypertensive patients without palpitation. In hypertensive patients with palpitation, 9 patients out of 27 patients have hyperkalaemia (33.3%), (serum potassium more than 3 mmol/L). In hypertensive patients without palpitation, only 3 patients out of 24 patients have hyperkalaemia (0.125%). In hypertensive men, there are no significant differences between group with palpitation & patients without palpitation regarding blood pressure in both systolic & diastolic. Also, there is no significant difference regarding heart rate between group of patients with palpitation & group of patients without palpitation. Palpitation can be attributed to one of the three main causes. The first cause is hyperdynamic circulation which includes hypercapnia, pyrexia, thyrotoxicosis, anemia & pregnancy. The second cause is sympathetic overdrive include panic disorders, hypoglycemia, hypoxia, heart failure & mitral valve prolapse. While the third main cause is arrhythmias. Tikrit University 2009 Article PeerReviewed application/pdf en http://irep.iium.edu.my/47660/1/Significance_of_palpitation_among_hypertensive_patients_receiving_captopril.pdf Marbut, Mossa M. and K. Rajab, Hassan and Al-Mahmood, Sinan (2009) Significance of palpitation among hypertensive patients receiving captopril. Medical Journal of Tikrit, 15 (2). pp. 32-37. ISSN 1683-1813 http://www.iasj.net/iasj?func=fulltext&aId=22233
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RM300 Drugs and their action
spellingShingle	RM300 Drugs and their action Marbut, Mossa M. K. Rajab, Hassan Al-Mahmood, Sinan Significance of palpitation among hypertensive patients receiving captopril
description	Captopril prevent the conversion of angiotensin 1 to II by inhibiting of peptidyl dipeptide carboxy hydrolase enzyme. Captopril is an angiotensin converting enzyme (ACE) inhibitors which is the treatment of hypertension. Hundred & eight hypertensive patients taking captoprill as a tablet 25 mg twice daily (47 men & 61 women). Each patient had a complete history detailed, physical examination, all patients were interviewed & full medical history was taken. All patients were questioned about the presence or absence of headache, palpitation, cough, flushing, chest pain, dysgeusia & tachycardia. Blood pressure & heart rate were measured for each patient each visit. In hypertensive men, 29 patients out of 47 (61.7%), hypertensive patients are diagnosed as suffering from palpitation. While in hypertensive women, 39 patients out of 61 women have palpitation after taking captopril for 3 months (64%). In regard to serum potassium, it was estimated in 51 hypertensive patients (27 with palpitation & 24 patients without palpitation). There is no significant difference in regarded to serum potassium between hypertensive patients with palpitation & hypertensive patients without palpitation. In hypertensive patients with palpitation, 9 patients out of 27 patients have hyperkalaemia (33.3%), (serum potassium more than 3 mmol/L). In hypertensive patients without palpitation, only 3 patients out of 24 patients have hyperkalaemia (0.125%). In hypertensive men, there are no significant differences between group with palpitation & patients without palpitation regarding blood pressure in both systolic & diastolic. Also, there is no significant difference regarding heart rate between group of patients with palpitation & group of patients without palpitation. Palpitation can be attributed to one of the three main causes. The first cause is hyperdynamic circulation which includes hypercapnia, pyrexia, thyrotoxicosis, anemia & pregnancy. The second cause is sympathetic overdrive include panic disorders, hypoglycemia, hypoxia, heart failure & mitral valve prolapse. While the third main cause is arrhythmias.
format	Article
author	Marbut, Mossa M. K. Rajab, Hassan Al-Mahmood, Sinan
author_facet	Marbut, Mossa M. K. Rajab, Hassan Al-Mahmood, Sinan
author_sort	Marbut, Mossa M.
title	Significance of palpitation among hypertensive patients receiving captopril
title_short	Significance of palpitation among hypertensive patients receiving captopril
title_full	Significance of palpitation among hypertensive patients receiving captopril
title_fullStr	Significance of palpitation among hypertensive patients receiving captopril
title_full_unstemmed	Significance of palpitation among hypertensive patients receiving captopril
title_sort	significance of palpitation among hypertensive patients receiving captopril
publisher	Tikrit University
publishDate	2009
url	http://irep.iium.edu.my/47660/ http://irep.iium.edu.my/47660/ http://irep.iium.edu.my/47660/1/Significance_of_palpitation_among_hypertensive_patients_receiving_captopril.pdf
first_indexed	2023-09-18T21:07:48Z
last_indexed	2023-09-18T21:07:48Z
_version_	1777411050156589056

Significance of palpitation among hypertensive patients receiving captopril

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