Significance of palpitation among hypertensive patients receiving captopril
Captopril prevent the conversion of angiotensin 1 to II by inhibiting of peptidyl dipeptide carboxy hydrolase enzyme. Captopril is an angiotensin converting enzyme (ACE) inhibitors which is the treatment of hypertension. Hundred & eight hypertensive patients taking captoprill as a tablet 25 m...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Tikrit University
2009
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/47660/ http://irep.iium.edu.my/47660/ http://irep.iium.edu.my/47660/1/Significance_of_palpitation_among_hypertensive_patients_receiving_captopril.pdf |
| Summary: | Captopril prevent the conversion of angiotensin 1 to II by inhibiting of peptidyl dipeptide
carboxy hydrolase enzyme. Captopril is an angiotensin converting enzyme (ACE) inhibitors which
is the treatment of hypertension. Hundred & eight hypertensive patients taking captoprill as a
tablet 25 mg twice daily (47 men & 61 women). Each patient had a complete history detailed,
physical examination, all patients were interviewed & full medical history was taken. All patients
were questioned about the presence or absence of headache, palpitation, cough, flushing, chest
pain, dysgeusia & tachycardia. Blood pressure & heart rate were measured for each patient each
visit. In hypertensive men, 29 patients out of 47 (61.7%), hypertensive patients are diagnosed as
suffering from palpitation. While in hypertensive women, 39 patients out of 61 women have
palpitation after taking captopril for 3 months (64%). In regard to serum potassium, it was
estimated in 51 hypertensive patients (27 with palpitation & 24 patients without palpitation). There
is no significant difference in regarded to serum potassium between hypertensive patients with
palpitation & hypertensive patients without palpitation. In hypertensive patients with palpitation, 9
patients out of 27 patients have hyperkalaemia (33.3%), (serum potassium more than 3 mmol/L).
In hypertensive patients without palpitation, only 3 patients out of 24 patients have hyperkalaemia
(0.125%). In hypertensive men, there are no significant differences between group with palpitation
& patients without palpitation regarding blood pressure in both systolic & diastolic. Also, there is
no significant difference regarding heart rate between group of patients with palpitation & group of
patients without palpitation. Palpitation can be attributed to one of the three main causes. The first
cause is hyperdynamic circulation which includes hypercapnia, pyrexia, thyrotoxicosis, anemia &
pregnancy. The second cause is sympathetic overdrive include panic disorders, hypoglycemia,
hypoxia, heart failure & mitral valve prolapse. While the third main cause is arrhythmias. |
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