In vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (Hos crl)

In vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (Hos crl)

Ferula assafoetida is a herb that has been used traditionally to treat rheumatism, broken bones and stomach illness. The aim of this research is to study the cytotoxicity of F. assafoetida as an anti-cancer agent. Briefly, resin of F. assafoetida was macerated with ethanol or methanol for 3 days. Th...

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Main Authors: Mohd Shafri, Mohd Affendi, Yusof, Fathin Athirah, Md Zain, Ahmad Zulkarami
Format: Article
Language:English
Published: Universiti Teknologi Malaysia 2015
Online Access:http://irep.iium.edu.my/47438/
http://irep.iium.edu.my/47438/
http://irep.iium.edu.my/47438/
http://irep.iium.edu.my/47438/1/5994-16777-1-SM.pdf
id iium-47438
recordtype eprints
spelling iium-474382016-07-15T02:14:13Z http://irep.iium.edu.my/47438/ In vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (Hos crl) Mohd Shafri, Mohd Affendi Yusof, Fathin Athirah Md Zain, Ahmad Zulkarami Ferula assafoetida is a herb that has been used traditionally to treat rheumatism, broken bones and stomach illness. The aim of this research is to study the cytotoxicity of F. assafoetida as an anti-cancer agent. Briefly, resin of F. assafoetida was macerated with ethanol or methanol for 3 days. The mixtures were then filtered, concentrated and dried. The cytotoxicity of extracts on an osteosarcoma cell line, HOS CRL, was determined using MTT assay method. The results were analysed with Tukey’s test (p<0.05) showed that F. assafoetida extract has cytotoxic effect which is dependent on the type of solvent (methanol > ethanol) and concentration (higher methanolic content > lower methanolic content). In conclusion, extracts of Ferula assafoetida might possess cytotoxic activity which could be useful to be developed for an anti-cancer treatment. Universiti Teknologi Malaysia 2015 Article PeerReviewed application/pdf en http://irep.iium.edu.my/47438/1/5994-16777-1-SM.pdf Mohd Shafri, Mohd Affendi and Yusof, Fathin Athirah and Md Zain, Ahmad Zulkarami (2015) In vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (Hos crl). Jurnal Teknologi, 77 (3). pp. 7-11. ISSN 0127–9696 E-ISSN 2180–3722 http://www.jurnalteknologi.utm.my/index.php/jurnalteknologi/article/view/5994 http://dx.doi.org/10.11113/jt.v77.5994
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
description Ferula assafoetida is a herb that has been used traditionally to treat rheumatism, broken bones and stomach illness. The aim of this research is to study the cytotoxicity of F. assafoetida as an anti-cancer agent. Briefly, resin of F. assafoetida was macerated with ethanol or methanol for 3 days. The mixtures were then filtered, concentrated and dried. The cytotoxicity of extracts on an osteosarcoma cell line, HOS CRL, was determined using MTT assay method. The results were analysed with Tukey’s test (p<0.05) showed that F. assafoetida extract has cytotoxic effect which is dependent on the type of solvent (methanol > ethanol) and concentration (higher methanolic content > lower methanolic content). In conclusion, extracts of Ferula assafoetida might possess cytotoxic activity which could be useful to be developed for an anti-cancer treatment.
format Article
author Mohd Shafri, Mohd Affendi
Yusof, Fathin Athirah
Md Zain, Ahmad Zulkarami
spellingShingle Mohd Shafri, Mohd Affendi
Yusof, Fathin Athirah
Md Zain, Ahmad Zulkarami
In vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (Hos crl)
author_facet Mohd Shafri, Mohd Affendi
Yusof, Fathin Athirah
Md Zain, Ahmad Zulkarami
author_sort Mohd Shafri, Mohd Affendi
title In vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (Hos crl)
title_short In vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (Hos crl)
title_full In vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (Hos crl)
title_fullStr In vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (Hos crl)
title_full_unstemmed In vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (Hos crl)
title_sort in vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (hos crl)
publisher Universiti Teknologi Malaysia
publishDate 2015
url http://irep.iium.edu.my/47438/
http://irep.iium.edu.my/47438/
http://irep.iium.edu.my/47438/
http://irep.iium.edu.my/47438/1/5994-16777-1-SM.pdf
first_indexed 2023-09-18T21:07:31Z
last_indexed 2023-09-18T21:07:31Z
_version_ 1777411032163024896

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