Formulation and characterization of resiquimod microsponges loaded gel

The aim of this study was to incorporate microponges loaded with resiquimod in gel dosage form. Microsponges were prepared by emulsion solvent evaporation method using dichloromethane (DCM), ethylacetate (EA), and chloroform in dispersed phase were incorporated into different gels. 0.5% w/w Carbopol...

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Main Authors:	Ab. Hadi, Hazrina, Zaiter, A., Awadh, Ammar Ihsan Jawad
Format:	Conference or Workshop Item
Language:	English English
Published:	2015
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/46091/ http://irep.iium.edu.my/46091/3/MPS_progr_book.pdf http://irep.iium.edu.my/46091/4/MPS_Microsponge_GEL.pdf

id	iium-46091
recordtype	eprints
spelling	iium-460912016-07-17T08:22:24Z http://irep.iium.edu.my/46091/ Formulation and characterization of resiquimod microsponges loaded gel Ab. Hadi, Hazrina Zaiter, A. Awadh, Ammar Ihsan Jawad RS Pharmacy and materia medica The aim of this study was to incorporate microponges loaded with resiquimod in gel dosage form. Microsponges were prepared by emulsion solvent evaporation method using dichloromethane (DCM), ethylacetate (EA), and chloroform in dispersed phase were incorporated into different gels. 0.5% w/w Carbopol® 934 (polyacrylic acid) powder was dispersed into deionized water under constant stirring with a glass rod. 0.2% and 0.02% w/w of methylparaben and propylparaben were used as preservative in the gel. The dispersion was neutralized using 10% sodium hydroxide (2% w/w). Topical microsponges gel formulations were prepared by incorporation of microsponges into the gel. A 0.03% w/w of resiquimod loaded microsponges was incorporated into the gel. Control gels which contained resiquimod only were prepared under the same conditions. Microsponges prepared by 2.5 mL of DCM, 1 mL of chloroform or 5 mL of EA in the dispersion phase were selected and coded as F1, F2 and F3. To study the compatibility of gel excipients along with microsponges, Attenuated Total Reflectance – Fourier Transform Infrared (ATR-FTIR) spectroscopy and FESEM microscopy were used. The ATR-FTIR spectrums of different formulations (F1, F2, and F3) are identical. F4 spectrum which contained empty microsponges loaded gel had no additional or missed peaks when compared against spectrums of other formulations. The integrity and surface morphology remained similar when compared to original microsponges observed under FESEM microscopy. Therefore, it can be concluded that there was no chemical interaction between resiquimod loaded microsponges and gel excipients as shown in ATR-FTIR spectrum and FESEM microscope. 2015 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/46091/3/MPS_progr_book.pdf application/pdf en http://irep.iium.edu.my/46091/4/MPS_Microsponge_GEL.pdf Ab. Hadi, Hazrina and Zaiter, A. and Awadh, Ammar Ihsan Jawad (2015) Formulation and characterization of resiquimod microsponges loaded gel. In: 12th MPS Malaysia Pharmacy Scientific Conference 2015, 13th-15th Nov 2015, Taylor's University, Lakeside Campus, Selangor, Malaysia. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Ab. Hadi, Hazrina Zaiter, A. Awadh, Ammar Ihsan Jawad Formulation and characterization of resiquimod microsponges loaded gel
description	The aim of this study was to incorporate microponges loaded with resiquimod in gel dosage form. Microsponges were prepared by emulsion solvent evaporation method using dichloromethane (DCM), ethylacetate (EA), and chloroform in dispersed phase were incorporated into different gels. 0.5% w/w Carbopol® 934 (polyacrylic acid) powder was dispersed into deionized water under constant stirring with a glass rod. 0.2% and 0.02% w/w of methylparaben and propylparaben were used as preservative in the gel. The dispersion was neutralized using 10% sodium hydroxide (2% w/w). Topical microsponges gel formulations were prepared by incorporation of microsponges into the gel. A 0.03% w/w of resiquimod loaded microsponges was incorporated into the gel. Control gels which contained resiquimod only were prepared under the same conditions. Microsponges prepared by 2.5 mL of DCM, 1 mL of chloroform or 5 mL of EA in the dispersion phase were selected and coded as F1, F2 and F3. To study the compatibility of gel excipients along with microsponges, Attenuated Total Reflectance – Fourier Transform Infrared (ATR-FTIR) spectroscopy and FESEM microscopy were used. The ATR-FTIR spectrums of different formulations (F1, F2, and F3) are identical. F4 spectrum which contained empty microsponges loaded gel had no additional or missed peaks when compared against spectrums of other formulations. The integrity and surface morphology remained similar when compared to original microsponges observed under FESEM microscopy. Therefore, it can be concluded that there was no chemical interaction between resiquimod loaded microsponges and gel excipients as shown in ATR-FTIR spectrum and FESEM microscope.
format	Conference or Workshop Item
author	Ab. Hadi, Hazrina Zaiter, A. Awadh, Ammar Ihsan Jawad
author_facet	Ab. Hadi, Hazrina Zaiter, A. Awadh, Ammar Ihsan Jawad
author_sort	Ab. Hadi, Hazrina
title	Formulation and characterization of resiquimod microsponges loaded gel
title_short	Formulation and characterization of resiquimod microsponges loaded gel
title_full	Formulation and characterization of resiquimod microsponges loaded gel
title_fullStr	Formulation and characterization of resiquimod microsponges loaded gel
title_full_unstemmed	Formulation and characterization of resiquimod microsponges loaded gel
title_sort	formulation and characterization of resiquimod microsponges loaded gel
publishDate	2015
url	http://irep.iium.edu.my/46091/ http://irep.iium.edu.my/46091/3/MPS_progr_book.pdf http://irep.iium.edu.my/46091/4/MPS_Microsponge_GEL.pdf
first_indexed	2023-09-18T21:05:36Z
last_indexed	2023-09-18T21:05:36Z
_version_	1777410911965806592

Formulation and characterization of resiquimod microsponges loaded gel

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