Apolipoprotein e gene polymorphisms in essential hypertension: a preliminary study with meta-analysis

Introduction: Essential hypertension is a multifactorial disease. Many experimental studies have elucidated the role of oxidative stress and atherosclerosis in the pathogenesis of essential hypertension. Apolipoprotein E is a plasma protein that is found to have antioxidant properties, and it also...

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Main Authors:	Ibrahim, Wisam Nabeel, Ku Zaifah, Norsidah, Draman, Samsul, Abdullah, Nor Zamzila, Mokhtar, Rafidah Hanim, A.Talib, Norlelawati
Format:	Article
Language:	English
Published:	The Faculty of Medicine, International Islamic University Malaysia 2015
Subjects:	QP Physiology
Online Access:	http://irep.iium.edu.my/46069/ http://irep.iium.edu.my/46069/ http://irep.iium.edu.my/46069/4/Pages-from-IMJM-Dec-2015-Final-39-46_2.pdf

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spelling	iium-460692017-06-16T02:17:27Z http://irep.iium.edu.my/46069/ Apolipoprotein e gene polymorphisms in essential hypertension: a preliminary study with meta-analysis Ibrahim, Wisam Nabeel Ku Zaifah, Norsidah Draman, Samsul Abdullah, Nor Zamzila Mokhtar, Rafidah Hanim A.Talib, Norlelawati QP Physiology Introduction: Essential hypertension is a multifactorial disease. Many experimental studies have elucidated the role of oxidative stress and atherosclerosis in the pathogenesis of essential hypertension. Apolipoprotein E is a plasma protein that is found to have antioxidant properties, and it also protects against atherosclerosis. Interestingly, the biological function of apolipoprotein E is strongly affected by polymorphisms in its gene. Based on this evidence, our aim was to investigate the association of apolipoprotein E gene polymorphisms with essential hypertension. Methods: This study was conducted on 70 hypertensive patients and 73 control participants recruited from the Balok governmental health clinic in Kuantan, Pahang. The polymerase chain reaction restriction fragment length polymorphism assay (PCR-RFLP) was used for determination of the apolipoprotein E genotype. Our results were also verified later by direct sequencing of the amplicons. Results: There was no significant association of apolipoprotein E allele or genotype frequencies with hypertensive disease or blood pressure levels, although the E4 allele was slightly more frequent in the hypertensive patients than in the control group (OR=1.055; 0.471–2.359, CI 95%). To improve the precision of the study and to settle the controversies among similar studies meta-analysis was performed; however it revealed a net nonsignificant association between the apolipoprotein E4 allele with essential hypertension in the combined population. Conclusion: Our data and the meta-analysis findings provide evidence that apolipoprotein E gene polymorphism has no direct significant association with hypertension. The Faculty of Medicine, International Islamic University Malaysia 2015-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/46069/4/Pages-from-IMJM-Dec-2015-Final-39-46_2.pdf Ibrahim, Wisam Nabeel and Ku Zaifah, Norsidah and Draman, Samsul and Abdullah, Nor Zamzila and Mokhtar, Rafidah Hanim and A.Talib, Norlelawati (2015) Apolipoprotein e gene polymorphisms in essential hypertension: a preliminary study with meta-analysis. The International Medical Journal Malaysia, 14 (2). pp. 39-46. ISSN 1823-4631 http://iiumedic.net/imjm/v1/246-2/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QP Physiology
spellingShingle	QP Physiology Ibrahim, Wisam Nabeel Ku Zaifah, Norsidah Draman, Samsul Abdullah, Nor Zamzila Mokhtar, Rafidah Hanim A.Talib, Norlelawati Apolipoprotein e gene polymorphisms in essential hypertension: a preliminary study with meta-analysis
description	Introduction: Essential hypertension is a multifactorial disease. Many experimental studies have elucidated the role of oxidative stress and atherosclerosis in the pathogenesis of essential hypertension. Apolipoprotein E is a plasma protein that is found to have antioxidant properties, and it also protects against atherosclerosis. Interestingly, the biological function of apolipoprotein E is strongly affected by polymorphisms in its gene. Based on this evidence, our aim was to investigate the association of apolipoprotein E gene polymorphisms with essential hypertension. Methods: This study was conducted on 70 hypertensive patients and 73 control participants recruited from the Balok governmental health clinic in Kuantan, Pahang. The polymerase chain reaction restriction fragment length polymorphism assay (PCR-RFLP) was used for determination of the apolipoprotein E genotype. Our results were also verified later by direct sequencing of the amplicons. Results: There was no significant association of apolipoprotein E allele or genotype frequencies with hypertensive disease or blood pressure levels, although the E4 allele was slightly more frequent in the hypertensive patients than in the control group (OR=1.055; 0.471–2.359, CI 95%). To improve the precision of the study and to settle the controversies among similar studies meta-analysis was performed; however it revealed a net nonsignificant association between the apolipoprotein E4 allele with essential hypertension in the combined population. Conclusion: Our data and the meta-analysis findings provide evidence that apolipoprotein E gene polymorphism has no direct significant association with hypertension.
format	Article
author	Ibrahim, Wisam Nabeel Ku Zaifah, Norsidah Draman, Samsul Abdullah, Nor Zamzila Mokhtar, Rafidah Hanim A.Talib, Norlelawati
author_facet	Ibrahim, Wisam Nabeel Ku Zaifah, Norsidah Draman, Samsul Abdullah, Nor Zamzila Mokhtar, Rafidah Hanim A.Talib, Norlelawati
author_sort	Ibrahim, Wisam Nabeel
title	Apolipoprotein e gene polymorphisms in essential hypertension: a preliminary study with meta-analysis
title_short	Apolipoprotein e gene polymorphisms in essential hypertension: a preliminary study with meta-analysis
title_full	Apolipoprotein e gene polymorphisms in essential hypertension: a preliminary study with meta-analysis
title_fullStr	Apolipoprotein e gene polymorphisms in essential hypertension: a preliminary study with meta-analysis
title_full_unstemmed	Apolipoprotein e gene polymorphisms in essential hypertension: a preliminary study with meta-analysis
title_sort	apolipoprotein e gene polymorphisms in essential hypertension: a preliminary study with meta-analysis
publisher	The Faculty of Medicine, International Islamic University Malaysia
publishDate	2015
url	http://irep.iium.edu.my/46069/ http://irep.iium.edu.my/46069/ http://irep.iium.edu.my/46069/4/Pages-from-IMJM-Dec-2015-Final-39-46_2.pdf
first_indexed	2023-09-18T21:05:34Z
last_indexed	2023-09-18T21:05:34Z
_version_	1777410909784768512

Apolipoprotein e gene polymorphisms in essential hypertension: a preliminary study with meta-analysis

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