Magnesium-doped biphasic calcium phosphate nanopowders via sol-gel method

Biphasic calcium phosphate (BCP) is a mixture of non-resorbable hydroxyapatite (HA) and the resorbable tricalcium phosphate (TCP) is an interesting material for bone implant as it shows biocompatibility and bioactivity to tissue bone. More efficient bone repair was widely been known in BCP than HA a...

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Main Authors:	Sopyan, Iis, Abdul Rahim, Toibah, Ahmad, Zainal Arifin
Other Authors:	Morris, Rachel E.
Format:	Book Chapter
Language:	English
Published:	Nova Science Publishers, Inc 2010
Subjects:	TA164 Bioengineering
Online Access:	http://irep.iium.edu.my/4590/ http://irep.iium.edu.my/4590/ http://irep.iium.edu.my/4590/1/23-Sopyan-p_NOVA.pdf

id	iium-4590
recordtype	eprints
spelling	iium-45902012-05-12T03:40:53Z http://irep.iium.edu.my/4590/ Magnesium-doped biphasic calcium phosphate nanopowders via sol-gel method Sopyan, Iis Abdul Rahim, Toibah Ahmad, Zainal Arifin TA164 Bioengineering Biphasic calcium phosphate (BCP) is a mixture of non-resorbable hydroxyapatite (HA) and the resorbable tricalcium phosphate (TCP) is an interesting material for bone implant as it shows biocompatibility and bioactivity to tissue bone. More efficient bone repair was widely been known in BCP than HA alone. Good implant materials should be biodegradable as it can degrade inside the bone and defect simultaneously with the formation of a new bone. In this study BCP has been doped with magnesium through sol-gel method. Doping of magnesium ions into BCP will results in biological improvement as the ion will cause the acceleration of nucleation kinetics of bone minerals. Magnesium depletion adversely affects all stages of skeletal metabolism, leading to decrease in osteoblastic activities and bone fragility. Magnesium–doped biphasic calcium phosphate (Mg-BCP) powders were successfully prepared using Ca(NO3)2.4H2O and (NH4)2HPO4 as the precursors and Mg(NO3)2.6H2O as the source of the dopant. Morphological evaluation by FESEM measurement showed that the particles of Mg-BCP were tightly agglomerated, with primary particulates of 50-150 nm diameters. FESEM result also showed that doping of magnesium into BCP particles caused fusion of particles leading to more progressive densification of particles as shown by higher concentration of magnesium doping. Successful incorporation of Mg into BCP lattice structure was confirmed by higher crystallinity of Mg-BCP and by shifting of tricalcium phosphate (TCP) peaks in XRD Nova Science Publishers, Inc Morris, Rachel E. 2010 Book Chapter PeerReviewed application/pdf en http://irep.iium.edu.my/4590/1/23-Sopyan-p_NOVA.pdf Sopyan, Iis and Abdul Rahim, Toibah and Ahmad, Zainal Arifin (2010) Magnesium-doped biphasic calcium phosphate nanopowders via sol-gel method. In: The Sol-Gel Process : Uniformity, Polymers and Applications. Nova Science Publishers, Inc. ISBN 978-1-61761-621-1 https://www.novapublishers.com/catalog/product_info.php?products_id=17606
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	TA164 Bioengineering
spellingShingle	TA164 Bioengineering Sopyan, Iis Abdul Rahim, Toibah Ahmad, Zainal Arifin Magnesium-doped biphasic calcium phosphate nanopowders via sol-gel method
description	Biphasic calcium phosphate (BCP) is a mixture of non-resorbable hydroxyapatite (HA) and the resorbable tricalcium phosphate (TCP) is an interesting material for bone implant as it shows biocompatibility and bioactivity to tissue bone. More efficient bone repair was widely been known in BCP than HA alone. Good implant materials should be biodegradable as it can degrade inside the bone and defect simultaneously with the formation of a new bone. In this study BCP has been doped with magnesium through sol-gel method. Doping of magnesium ions into BCP will results in biological improvement as the ion will cause the acceleration of nucleation kinetics of bone minerals. Magnesium depletion adversely affects all stages of skeletal metabolism, leading to decrease in osteoblastic activities and bone fragility. Magnesium–doped biphasic calcium phosphate (Mg-BCP) powders were successfully prepared using Ca(NO3)2.4H2O and (NH4)2HPO4 as the precursors and Mg(NO3)2.6H2O as the source of the dopant. Morphological evaluation by FESEM measurement showed that the particles of Mg-BCP were tightly agglomerated, with primary particulates of 50-150 nm diameters. FESEM result also showed that doping of magnesium into BCP particles caused fusion of particles leading to more progressive densification of particles as shown by higher concentration of magnesium doping. Successful incorporation of Mg into BCP lattice structure was confirmed by higher crystallinity of Mg-BCP and by shifting of tricalcium phosphate (TCP) peaks in XRD
author2	Morris, Rachel E.
author_facet	Morris, Rachel E. Sopyan, Iis Abdul Rahim, Toibah Ahmad, Zainal Arifin
format	Book Chapter
author	Sopyan, Iis Abdul Rahim, Toibah Ahmad, Zainal Arifin
author_sort	Sopyan, Iis
title	Magnesium-doped biphasic calcium phosphate nanopowders via sol-gel method
title_short	Magnesium-doped biphasic calcium phosphate nanopowders via sol-gel method
title_full	Magnesium-doped biphasic calcium phosphate nanopowders via sol-gel method
title_fullStr	Magnesium-doped biphasic calcium phosphate nanopowders via sol-gel method
title_full_unstemmed	Magnesium-doped biphasic calcium phosphate nanopowders via sol-gel method
title_sort	magnesium-doped biphasic calcium phosphate nanopowders via sol-gel method
publisher	Nova Science Publishers, Inc
publishDate	2010
url	http://irep.iium.edu.my/4590/ http://irep.iium.edu.my/4590/ http://irep.iium.edu.my/4590/1/23-Sopyan-p_NOVA.pdf
first_indexed	2023-09-18T20:12:52Z
last_indexed	2023-09-18T20:12:52Z
_version_	1777407593842475008

Magnesium-doped biphasic calcium phosphate nanopowders via sol-gel method

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