An investigation into the antiobesity effects of morinda citrifolia l. leaf extract in high fat diet induced obese rats using a 1H NMR metabolomics approach

Theprevalence of obesity is increasingworldwide,with high fat diet (HFD) as one of themain contributing factors.Obesity increases the predisposition to other diseases such as diabetes through various metabolic pathways. Limited availability of antiobesity drugs and the popularity of complementary...

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Main Authors:	Jambocus, Najla Gooda Sahib, Saari, Nazamid, Ismail, Amin, Khatib, Alfi, Mahomoodally, Mohamad Fawzi, Abdul Hamid, Azizah
Format:	Article
Language:	English English
Published:	Hindawi Publishing Corporation 2016
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/45851/ http://irep.iium.edu.my/45851/ http://irep.iium.edu.my/45851/ http://irep.iium.edu.my/45851/1/45851.pdf http://irep.iium.edu.my/45851/4/45851_An%20investigation%20into%20the%20antiobesity_Scopus.pdf

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spelling	iium-458512017-10-20T14:56:24Z http://irep.iium.edu.my/45851/ An investigation into the antiobesity effects of morinda citrifolia l. leaf extract in high fat diet induced obese rats using a 1H NMR metabolomics approach Jambocus, Najla Gooda Sahib Saari, Nazamid Ismail, Amin Khatib, Alfi Mahomoodally, Mohamad Fawzi Abdul Hamid, Azizah Q Science (General) Theprevalence of obesity is increasingworldwide,with high fat diet (HFD) as one of themain contributing factors.Obesity increases the predisposition to other diseases such as diabetes through various metabolic pathways. Limited availability of antiobesity drugs and the popularity of complementary medicine have encouraged research in finding phytochemical strategies to this multifaceted disease. HFD induced obese Sprague-Dawley rats were treated with an extract of Morinda citrifolia L. leaves (MLE 60). After 9 weeks of treatment, positive effects were observed on adiposity, fecal fat content, plasma lipids, and insulin and leptin levels. The inducement of obesity and treatment with MLE 60 on metabolic alterations were then further elucidated using a 1H NMR based metabolomics approach. Discriminating metabolites involved were products of various metabolic pathways, including glucose metabolism and TCA cycle (lactate, 2-oxoglutarate, citrate, succinate, pyruvate, and acetate), amino acid metabolism (alanine, 2-hydroxybutyrate), choline metabolism (betaine), creatinine metabolism (creatinine), and gut microbiome metabolism (hippurate, phenylacetylglycine, dimethylamine, and trigonelline). Treatment with MLE 60 resulted in significant improvement in the metabolic perturbations caused obesity as demonstrated by the proximity of the treated group to the normal group in the OPLS-DA score plot and the change in trajectory movement of the diseased group towards the healthy group upon treatment. Hindawi Publishing Corporation 2016 Article PeerReviewed application/pdf en http://irep.iium.edu.my/45851/1/45851.pdf application/pdf en http://irep.iium.edu.my/45851/4/45851_An%20investigation%20into%20the%20antiobesity_Scopus.pdf Jambocus, Najla Gooda Sahib and Saari, Nazamid and Ismail, Amin and Khatib, Alfi and Mahomoodally, Mohamad Fawzi and Abdul Hamid, Azizah (2016) An investigation into the antiobesity effects of morinda citrifolia l. leaf extract in high fat diet induced obese rats using a 1H NMR metabolomics approach. Journal of Diabetes Research, 2016. 2391592-1-2391592-15. ISSN 2314-6745 http://www.hindawi.com/journals/jdr/2016/2391592/ 10.1155/2016/2391592
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	Q Science (General)
spellingShingle	Q Science (General) Jambocus, Najla Gooda Sahib Saari, Nazamid Ismail, Amin Khatib, Alfi Mahomoodally, Mohamad Fawzi Abdul Hamid, Azizah An investigation into the antiobesity effects of morinda citrifolia l. leaf extract in high fat diet induced obese rats using a 1H NMR metabolomics approach
description	Theprevalence of obesity is increasingworldwide,with high fat diet (HFD) as one of themain contributing factors.Obesity increases the predisposition to other diseases such as diabetes through various metabolic pathways. Limited availability of antiobesity drugs and the popularity of complementary medicine have encouraged research in finding phytochemical strategies to this multifaceted disease. HFD induced obese Sprague-Dawley rats were treated with an extract of Morinda citrifolia L. leaves (MLE 60). After 9 weeks of treatment, positive effects were observed on adiposity, fecal fat content, plasma lipids, and insulin and leptin levels. The inducement of obesity and treatment with MLE 60 on metabolic alterations were then further elucidated using a 1H NMR based metabolomics approach. Discriminating metabolites involved were products of various metabolic pathways, including glucose metabolism and TCA cycle (lactate, 2-oxoglutarate, citrate, succinate, pyruvate, and acetate), amino acid metabolism (alanine, 2-hydroxybutyrate), choline metabolism (betaine), creatinine metabolism (creatinine), and gut microbiome metabolism (hippurate, phenylacetylglycine, dimethylamine, and trigonelline). Treatment with MLE 60 resulted in significant improvement in the metabolic perturbations caused obesity as demonstrated by the proximity of the treated group to the normal group in the OPLS-DA score plot and the change in trajectory movement of the diseased group towards the healthy group upon treatment.
format	Article
author	Jambocus, Najla Gooda Sahib Saari, Nazamid Ismail, Amin Khatib, Alfi Mahomoodally, Mohamad Fawzi Abdul Hamid, Azizah
author_facet	Jambocus, Najla Gooda Sahib Saari, Nazamid Ismail, Amin Khatib, Alfi Mahomoodally, Mohamad Fawzi Abdul Hamid, Azizah
author_sort	Jambocus, Najla Gooda Sahib
title	An investigation into the antiobesity effects of morinda citrifolia l. leaf extract in high fat diet induced obese rats using a 1H NMR metabolomics approach
title_short	An investigation into the antiobesity effects of morinda citrifolia l. leaf extract in high fat diet induced obese rats using a 1H NMR metabolomics approach
title_full	An investigation into the antiobesity effects of morinda citrifolia l. leaf extract in high fat diet induced obese rats using a 1H NMR metabolomics approach
title_fullStr	An investigation into the antiobesity effects of morinda citrifolia l. leaf extract in high fat diet induced obese rats using a 1H NMR metabolomics approach
title_full_unstemmed	An investigation into the antiobesity effects of morinda citrifolia l. leaf extract in high fat diet induced obese rats using a 1H NMR metabolomics approach
title_sort	investigation into the antiobesity effects of morinda citrifolia l. leaf extract in high fat diet induced obese rats using a 1h nmr metabolomics approach
publisher	Hindawi Publishing Corporation
publishDate	2016
url	http://irep.iium.edu.my/45851/ http://irep.iium.edu.my/45851/ http://irep.iium.edu.my/45851/ http://irep.iium.edu.my/45851/1/45851.pdf http://irep.iium.edu.my/45851/4/45851_An%20investigation%20into%20the%20antiobesity_Scopus.pdf
first_indexed	2023-09-18T21:05:15Z
last_indexed	2023-09-18T21:05:15Z
_version_	1777410890508795904

An investigation into the antiobesity effects of morinda citrifolia l. leaf extract in high fat diet induced obese rats using a 1H NMR metabolomics approach

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