Differential scanning calorimetric characterization of pharmaceutical powder blend uniformity in a laboratory-scale V-blender

Testing of powder blend uniformity is one of the important steps during formulation development and routine commercial production of pharmaceutical products. Pharmaceutical industries heavily rely on chemical analysis by UV or HPLC for the same. However, the chemical methods are time consuming, need...

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Main Authors:	Mahmood, Syed, Hilmi, Nur Nadhirah, Husain, Nur Khairunnisa, Chatterjee, Bappaditya, Mandal, Uttam Kumar
Format:	Article
Language:	English English
Published:	Elsevier 2015
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/45475/ http://irep.iium.edu.my/45475/ http://irep.iium.edu.my/45475/ http://irep.iium.edu.my/45475/1/1-s2.0-S0032591015300930-main.pdf http://irep.iium.edu.my/45475/4/45475_Differential%20scanning%20calorimetric_WOS_SCOPUS.pdf

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spelling	iium-454752017-04-13T06:30:54Z http://irep.iium.edu.my/45475/ Differential scanning calorimetric characterization of pharmaceutical powder blend uniformity in a laboratory-scale V-blender Mahmood, Syed Hilmi, Nur Nadhirah Husain, Nur Khairunnisa Chatterjee, Bappaditya Mandal, Uttam Kumar RS Pharmacy and materia medica Testing of powder blend uniformity is one of the important steps during formulation development and routine commercial production of pharmaceutical products. Pharmaceutical industries heavily rely on chemical analysis by UV or HPLC for the same. However, the chemical methods are time consuming, need a few grams of powder sample, and they are not green in nature. The objective of this research is to explore the use of DSC as an alternative of UV analysis to assess the powder blend uniformity of a binary mixture of metformin hydrochloride and HPMC (5:95 w/w) at 50% and 60% occupancy of a laboratory-scale V-blender. Samples were withdrawn at 5, 10, 15, and 20 min intervals each of the top, middle, and bottom positions of the blender. Samples from all three locations at all time-points were found to have similar concentrations by both methods with the maximum RSD below 26%. Percent of metformin HCl recovery from the powder mixture after 20 min was comparable to the DSC method (2.68 ± 0.22% and 2.29 ± 0.14% at 50% and 60% occupancy, respectively) and UV method (2.66 ± 1.10% and 2.60 ± 0.32% at 50% and 60% occupancy levels, respectively). DSC, after a careful evaluation of drug and excipient specific interaction, can be considered as an alternative of pharmacopoeial spectrophotometric or chromatographic methods for powder blend uniformity assessment at various stages of pharmaceutical product development and its commercial production. Elsevier 2015-10-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/45475/1/1-s2.0-S0032591015300930-main.pdf application/pdf en http://irep.iium.edu.my/45475/4/45475_Differential%20scanning%20calorimetric_WOS_SCOPUS.pdf Mahmood, Syed and Hilmi, Nur Nadhirah and Husain, Nur Khairunnisa and Chatterjee, Bappaditya and Mandal, Uttam Kumar (2015) Differential scanning calorimetric characterization of pharmaceutical powder blend uniformity in a laboratory-scale V-blender. Powder Technology, 287. pp. 152-159. ISSN 0032-5910 http://www.sciencedirect.com/science/article/pii/S0032591015300930 10.1016/j.powtec.2015.10.004
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Mahmood, Syed Hilmi, Nur Nadhirah Husain, Nur Khairunnisa Chatterjee, Bappaditya Mandal, Uttam Kumar Differential scanning calorimetric characterization of pharmaceutical powder blend uniformity in a laboratory-scale V-blender
description	Testing of powder blend uniformity is one of the important steps during formulation development and routine commercial production of pharmaceutical products. Pharmaceutical industries heavily rely on chemical analysis by UV or HPLC for the same. However, the chemical methods are time consuming, need a few grams of powder sample, and they are not green in nature. The objective of this research is to explore the use of DSC as an alternative of UV analysis to assess the powder blend uniformity of a binary mixture of metformin hydrochloride and HPMC (5:95 w/w) at 50% and 60% occupancy of a laboratory-scale V-blender. Samples were withdrawn at 5, 10, 15, and 20 min intervals each of the top, middle, and bottom positions of the blender. Samples from all three locations at all time-points were found to have similar concentrations by both methods with the maximum RSD below 26%. Percent of metformin HCl recovery from the powder mixture after 20 min was comparable to the DSC method (2.68 ± 0.22% and 2.29 ± 0.14% at 50% and 60% occupancy, respectively) and UV method (2.66 ± 1.10% and 2.60 ± 0.32% at 50% and 60% occupancy levels, respectively). DSC, after a careful evaluation of drug and excipient specific interaction, can be considered as an alternative of pharmacopoeial spectrophotometric or chromatographic methods for powder blend uniformity assessment at various stages of pharmaceutical product development and its commercial production.
format	Article
author	Mahmood, Syed Hilmi, Nur Nadhirah Husain, Nur Khairunnisa Chatterjee, Bappaditya Mandal, Uttam Kumar
author_facet	Mahmood, Syed Hilmi, Nur Nadhirah Husain, Nur Khairunnisa Chatterjee, Bappaditya Mandal, Uttam Kumar
author_sort	Mahmood, Syed
title	Differential scanning calorimetric characterization of pharmaceutical powder blend uniformity in a laboratory-scale V-blender
title_short	Differential scanning calorimetric characterization of pharmaceutical powder blend uniformity in a laboratory-scale V-blender
title_full	Differential scanning calorimetric characterization of pharmaceutical powder blend uniformity in a laboratory-scale V-blender
title_fullStr	Differential scanning calorimetric characterization of pharmaceutical powder blend uniformity in a laboratory-scale V-blender
title_full_unstemmed	Differential scanning calorimetric characterization of pharmaceutical powder blend uniformity in a laboratory-scale V-blender
title_sort	differential scanning calorimetric characterization of pharmaceutical powder blend uniformity in a laboratory-scale v-blender
publisher	Elsevier
publishDate	2015
url	http://irep.iium.edu.my/45475/ http://irep.iium.edu.my/45475/ http://irep.iium.edu.my/45475/ http://irep.iium.edu.my/45475/1/1-s2.0-S0032591015300930-main.pdf http://irep.iium.edu.my/45475/4/45475_Differential%20scanning%20calorimetric_WOS_SCOPUS.pdf
first_indexed	2023-09-18T21:04:43Z
last_indexed	2023-09-18T21:04:43Z
_version_	1777410856979529728

Differential scanning calorimetric characterization of pharmaceutical powder blend uniformity in a laboratory-scale V-blender

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