Exploring powder blend uniformity of a binary mixture containing metformin HCl and HPMC by differential scanning calorimetry (DSC)

Exploring powder blend uniformity of a binary mixture containing metformin HCl and HPMC by differential scanning calorimetry (DSC)

V Blender, also known as twin–shell mixer, is widely used in pharmaceutical industries for mixing powders, granules, and other solid materials1-2. Its mixing mechanism involves continuous splitting, followed by intermixing of powder materials as the shell rotates on its horizontal axis. Powder mixi...

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Main Authors: Hilmi, Nur Nadhirah, Husain, Nur Khairunnisa, Mahmood, Syed, Chatterjee, Bappaditya, Mandal, Uttam Kumar
Format: Conference or Workshop Item
Language:English
Published: 2015
Subjects:
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/45278/
http://irep.iium.edu.my/45278/1/45278.pdf
id iium-45278
recordtype eprints
spelling iium-452782016-05-22T23:56:38Z http://irep.iium.edu.my/45278/ Exploring powder blend uniformity of a binary mixture containing metformin HCl and HPMC by differential scanning calorimetry (DSC) Hilmi, Nur Nadhirah Husain, Nur Khairunnisa Mahmood, Syed Chatterjee, Bappaditya Mandal, Uttam Kumar RS Pharmacy and materia medica V Blender, also known as twin–shell mixer, is widely used in pharmaceutical industries for mixing powders, granules, and other solid materials1-2. Its mixing mechanism involves continuous splitting, followed by intermixing of powder materials as the shell rotates on its horizontal axis. Powder mixing is considered a critical step in process scale up during pharmaceutical product development as well as routine commercial manufacturing3. However, the Pharmaceutical Industries heavily rely on chemical analysis of active drug present in the powder mixture by UV or HPLC for the same. The objective of this research work is to analyze mixing uniformity of a binary mixture containing HPMC and metformin HCl (95:5 w/w) at 50% and 60% occupancy of a laboratory scale V blender. The results of the DSC method were further confirmed by a UV method. Powder samples were withdrawn at 5 min, 10 min, 15 min, and 20 min intervals each of the top, middle, and bottom positions of the blender. Recovery of metformin HCl after 20 min of mixing by both the UV method (2.66±1.10% and 2.60±0.32% at 50% and 60% occupancy levels, respectively) and the DSC method (2.68±0.22% and 2.29±0.14% at 50% and 60% occupancy, respectively) were found to have similar trends. Also, maximum RSD of enthalpy (21.55 at 10 min at 50% occupancy) for sample analysis by the DSC method was comparable to that of the UV method (25.201 at 15 min at 50% occupancy). DSC method can be further explored as an alternative of UV spectroscopy or HPLC method to assess the mixing uniformity of powder samples in pharmaceutical industries. 2015-10-10 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/45278/1/45278.pdf Hilmi, Nur Nadhirah and Husain, Nur Khairunnisa and Mahmood, Syed and Chatterjee, Bappaditya and Mandal, Uttam Kumar (2015) Exploring powder blend uniformity of a binary mixture containing metformin HCl and HPMC by differential scanning calorimetry (DSC). In: Health and Pharmaceutical Sciences Undergraduate Research Symposium, 10th October, 2015, Le Quadri Ball Room, KL campus, North Wing, UCSI University, KL, Malaysia. (Unpublished)
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Hilmi, Nur Nadhirah
Husain, Nur Khairunnisa
Mahmood, Syed
Chatterjee, Bappaditya
Mandal, Uttam Kumar
Exploring powder blend uniformity of a binary mixture containing metformin HCl and HPMC by differential scanning calorimetry (DSC)
description V Blender, also known as twin–shell mixer, is widely used in pharmaceutical industries for mixing powders, granules, and other solid materials1-2. Its mixing mechanism involves continuous splitting, followed by intermixing of powder materials as the shell rotates on its horizontal axis. Powder mixing is considered a critical step in process scale up during pharmaceutical product development as well as routine commercial manufacturing3. However, the Pharmaceutical Industries heavily rely on chemical analysis of active drug present in the powder mixture by UV or HPLC for the same. The objective of this research work is to analyze mixing uniformity of a binary mixture containing HPMC and metformin HCl (95:5 w/w) at 50% and 60% occupancy of a laboratory scale V blender. The results of the DSC method were further confirmed by a UV method. Powder samples were withdrawn at 5 min, 10 min, 15 min, and 20 min intervals each of the top, middle, and bottom positions of the blender. Recovery of metformin HCl after 20 min of mixing by both the UV method (2.66±1.10% and 2.60±0.32% at 50% and 60% occupancy levels, respectively) and the DSC method (2.68±0.22% and 2.29±0.14% at 50% and 60% occupancy, respectively) were found to have similar trends. Also, maximum RSD of enthalpy (21.55 at 10 min at 50% occupancy) for sample analysis by the DSC method was comparable to that of the UV method (25.201 at 15 min at 50% occupancy). DSC method can be further explored as an alternative of UV spectroscopy or HPLC method to assess the mixing uniformity of powder samples in pharmaceutical industries.
format Conference or Workshop Item
author Hilmi, Nur Nadhirah
Husain, Nur Khairunnisa
Mahmood, Syed
Chatterjee, Bappaditya
Mandal, Uttam Kumar
author_facet Hilmi, Nur Nadhirah
Husain, Nur Khairunnisa
Mahmood, Syed
Chatterjee, Bappaditya
Mandal, Uttam Kumar
author_sort Hilmi, Nur Nadhirah
title Exploring powder blend uniformity of a binary mixture containing metformin HCl and HPMC by differential scanning calorimetry (DSC)
title_short Exploring powder blend uniformity of a binary mixture containing metformin HCl and HPMC by differential scanning calorimetry (DSC)
title_full Exploring powder blend uniformity of a binary mixture containing metformin HCl and HPMC by differential scanning calorimetry (DSC)
title_fullStr Exploring powder blend uniformity of a binary mixture containing metformin HCl and HPMC by differential scanning calorimetry (DSC)
title_full_unstemmed Exploring powder blend uniformity of a binary mixture containing metformin HCl and HPMC by differential scanning calorimetry (DSC)
title_sort exploring powder blend uniformity of a binary mixture containing metformin hcl and hpmc by differential scanning calorimetry (dsc)
publishDate 2015
url http://irep.iium.edu.my/45278/
http://irep.iium.edu.my/45278/1/45278.pdf
first_indexed 2023-09-18T21:04:27Z
last_indexed 2023-09-18T21:04:27Z
_version_ 1777410840055513088

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