Polymer selection for nisoldipine solid dispersion to enhance solubility
Nisoldipine is a very potent calcium channel blocker which is used as anti-hypertensive agent. Although it is prescribed widely as oral tablet, its use has been limited due to poor bioavailability which arises from its poor water solubility. Hot Melt solid dispersion of poorly water-soluble drug i...
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| Format: | Conference or Workshop Item |
| Language: | English |
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2015
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| Online Access: | http://irep.iium.edu.my/45273/ http://irep.iium.edu.my/45273/1/45273.pdf |
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iium-45273 |
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iium-452732018-06-21T02:47:35Z http://irep.iium.edu.my/45273/ Polymer selection for nisoldipine solid dispersion to enhance solubility Kyaw Oo, May Chatterjee, Bappaditya RS Pharmacy and materia medica Nisoldipine is a very potent calcium channel blocker which is used as anti-hypertensive agent. Although it is prescribed widely as oral tablet, its use has been limited due to poor bioavailability which arises from its poor water solubility. Hot Melt solid dispersion of poorly water-soluble drug in long chain polymer is a common approach to enhance solubility and bioavailability. However, there is only little data available on the selection of polymer type and ratio which are critical parameters for solid dispersion. The present study aimed to compare the effect of different polymers on nisoldipine solid dispersion and to investigate the type and range of polymers with optimum nisoldipine solubility. 2015-11-12 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/45273/1/45273.pdf Kyaw Oo, May and Chatterjee, Bappaditya (2015) Polymer selection for nisoldipine solid dispersion to enhance solubility. In: 4th International Conference on Pharmaceuticals, Nutraceuticals and Cosmetic Science (UPNaCS 2015), 12th-13th Nov. 2015, Ramada Plaza, Melaka. (Unpublished) |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
RS Pharmacy and materia medica |
| spellingShingle |
RS Pharmacy and materia medica Kyaw Oo, May Chatterjee, Bappaditya Polymer selection for nisoldipine solid dispersion to enhance solubility |
| description |
Nisoldipine is a very potent calcium channel blocker which is used as anti-hypertensive agent. Although it is prescribed widely as oral
tablet, its use has been limited due to poor bioavailability which arises from its poor water solubility. Hot Melt solid dispersion of
poorly water-soluble drug in long chain polymer is a common approach to enhance solubility and bioavailability. However, there is
only little data available on the selection of polymer type and ratio which are critical parameters for solid dispersion. The present
study aimed to compare the effect of different polymers on nisoldipine solid dispersion and to investigate the type and range of
polymers with optimum nisoldipine solubility. |
| format |
Conference or Workshop Item |
| author |
Kyaw Oo, May Chatterjee, Bappaditya |
| author_facet |
Kyaw Oo, May Chatterjee, Bappaditya |
| author_sort |
Kyaw Oo, May |
| title |
Polymer selection for nisoldipine solid dispersion to enhance solubility |
| title_short |
Polymer selection for nisoldipine solid dispersion to enhance solubility |
| title_full |
Polymer selection for nisoldipine solid dispersion to enhance solubility |
| title_fullStr |
Polymer selection for nisoldipine solid dispersion to enhance solubility |
| title_full_unstemmed |
Polymer selection for nisoldipine solid dispersion to enhance solubility |
| title_sort |
polymer selection for nisoldipine solid dispersion to enhance solubility |
| publishDate |
2015 |
| url |
http://irep.iium.edu.my/45273/ http://irep.iium.edu.my/45273/1/45273.pdf |
| first_indexed |
2023-09-18T21:04:27Z |
| last_indexed |
2023-09-18T21:04:27Z |
| _version_ |
1777410839469359104 |