Polymer selection for nisoldipine solid dispersion to enhance solubility
Nisoldipine is a very potent calcium channel blocker which is used as anti-hypertensive agent. Although it is prescribed widely as oral tablet, its use has been limited due to poor bioavailability which arises from its poor water solubility. Hot Melt solid dispersion of poorly water-soluble drug i...
| Main Authors: | , |
|---|---|
| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2015
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/45273/ http://irep.iium.edu.my/45273/1/45273.pdf |
| Summary: | Nisoldipine is a very potent calcium channel blocker which is used as anti-hypertensive agent. Although it is prescribed widely as oral
tablet, its use has been limited due to poor bioavailability which arises from its poor water solubility. Hot Melt solid dispersion of
poorly water-soluble drug in long chain polymer is a common approach to enhance solubility and bioavailability. However, there is
only little data available on the selection of polymer type and ratio which are critical parameters for solid dispersion. The present
study aimed to compare the effect of different polymers on nisoldipine solid dispersion and to investigate the type and range of
polymers with optimum nisoldipine solubility. |
|---|