Hyaluronate lyase production by streptococcus pneumoniae isolated from patients and carriers

Hyaluronate lyase produced by various microorganisms is capable of degrading hyaluronic acid in connective tissue and initiating spread of infection by opening an access for the pathogen into host tissues. The present study attempts to determine the distribution of hyaluronate lyase-producing Strept...

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Main Authors:	Ahmad Yusof @ Hanafi, Hanani, Mohd Desa, Mohd Nasir, Masri, Siti Norbaya, Osman, Malina, Jamal, Farida
Format:	Article
Language:	English English
Published:	Malaysian Society of Parasitology and Tropical Medicine 2015
Subjects:	QR Microbiology
Online Access:	http://irep.iium.edu.my/45269/ http://irep.iium.edu.my/45269/ http://irep.iium.edu.my/45269/1/Acceptance_letter.pdf http://irep.iium.edu.my/45269/2/Full_text.pdf

id	iium-45269
recordtype	eprints
spelling	iium-452692015-10-21T07:05:49Z http://irep.iium.edu.my/45269/ Hyaluronate lyase production by streptococcus pneumoniae isolated from patients and carriers Ahmad Yusof @ Hanafi, Hanani Mohd Desa, Mohd Nasir Masri, Siti Norbaya Osman, Malina Jamal, Farida QR Microbiology Hyaluronate lyase produced by various microorganisms is capable of degrading hyaluronic acid in connective tissue and initiating spread of infection by opening an access for the pathogen into host tissues. The present study attempts to determine the distribution of hyaluronate lyase-producing Streptococcus pneumoniae among invasive, non-invasive and carriage isolates, and correlate it with the clinical sources, year of isolation, colonial morphology and their serotypes. A total of 100 isolates from various clinical samples were selected and screened for hyaluronate lyase production and presence of the encoding SpnHyl gene. All isolates possessed SpnHyl gene. Ninety-six isolates including 34 carriage isolates were positive for production of hyaluronate lyase. Four hyaluronate lyase-negative isolates were from blood (2 isolates) and sputum (2 isolates). No significant association was detected among hyaluronate lyase production and bacterial characteristics except for colonial morphology (p = 0.040). High percentages of hyaluronate lyase production in these isolates suggest their possible role as human pathogens. Malaysian Society of Parasitology and Tropical Medicine 2015 Article PeerReviewed application/pdf en http://irep.iium.edu.my/45269/1/Acceptance_letter.pdf application/pdf en http://irep.iium.edu.my/45269/2/Full_text.pdf Ahmad Yusof @ Hanafi, Hanani and Mohd Desa, Mohd Nasir and Masri, Siti Norbaya and Osman, Malina and Jamal, Farida (2015) Hyaluronate lyase production by streptococcus pneumoniae isolated from patients and carriers. Tropical Biomedicine, 32 (3). pp. 1-12. ISSN 1239-5720 (In Press) http://www.msptm.org/journal.html
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QR Microbiology
spellingShingle	QR Microbiology Ahmad Yusof @ Hanafi, Hanani Mohd Desa, Mohd Nasir Masri, Siti Norbaya Osman, Malina Jamal, Farida Hyaluronate lyase production by streptococcus pneumoniae isolated from patients and carriers
description	Hyaluronate lyase produced by various microorganisms is capable of degrading hyaluronic acid in connective tissue and initiating spread of infection by opening an access for the pathogen into host tissues. The present study attempts to determine the distribution of hyaluronate lyase-producing Streptococcus pneumoniae among invasive, non-invasive and carriage isolates, and correlate it with the clinical sources, year of isolation, colonial morphology and their serotypes. A total of 100 isolates from various clinical samples were selected and screened for hyaluronate lyase production and presence of the encoding SpnHyl gene. All isolates possessed SpnHyl gene. Ninety-six isolates including 34 carriage isolates were positive for production of hyaluronate lyase. Four hyaluronate lyase-negative isolates were from blood (2 isolates) and sputum (2 isolates). No significant association was detected among hyaluronate lyase production and bacterial characteristics except for colonial morphology (p = 0.040). High percentages of hyaluronate lyase production in these isolates suggest their possible role as human pathogens.
format	Article
author	Ahmad Yusof @ Hanafi, Hanani Mohd Desa, Mohd Nasir Masri, Siti Norbaya Osman, Malina Jamal, Farida
author_facet	Ahmad Yusof @ Hanafi, Hanani Mohd Desa, Mohd Nasir Masri, Siti Norbaya Osman, Malina Jamal, Farida
author_sort	Ahmad Yusof @ Hanafi, Hanani
title	Hyaluronate lyase production by streptococcus pneumoniae isolated from patients and carriers
title_short	Hyaluronate lyase production by streptococcus pneumoniae isolated from patients and carriers
title_full	Hyaluronate lyase production by streptococcus pneumoniae isolated from patients and carriers
title_fullStr	Hyaluronate lyase production by streptococcus pneumoniae isolated from patients and carriers
title_full_unstemmed	Hyaluronate lyase production by streptococcus pneumoniae isolated from patients and carriers
title_sort	hyaluronate lyase production by streptococcus pneumoniae isolated from patients and carriers
publisher	Malaysian Society of Parasitology and Tropical Medicine
publishDate	2015
url	http://irep.iium.edu.my/45269/ http://irep.iium.edu.my/45269/ http://irep.iium.edu.my/45269/1/Acceptance_letter.pdf http://irep.iium.edu.my/45269/2/Full_text.pdf
first_indexed	2023-09-18T21:04:26Z
last_indexed	2023-09-18T21:04:26Z
_version_	1777410838881107968

Hyaluronate lyase production by streptococcus pneumoniae isolated from patients and carriers

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